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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jag1Mhdahtu
Martin Hrabe de Angelis headturner
MGI:2386949
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Jag1Mhdahtu/Jag1Mhdahtu C3HeB/FeJ-Jag1Mhdahtu MGI:3717463
ht2
Jag1Mhdahtu/Jag1+ C3HeB/FeJ-Jag1Mhdahtu MGI:3717461
ht3
Jag1Mhdahtu/Jag1Slalom involves: BALB/c * C3H * C3HeB/FeJ MGI:3717465
cx4
Jag1Mhdahtu/Jag1+
Six1Cwe/Six1+
C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe MGI:3849174


Genotype
MGI:3717463
hm1
Allelic
Composition
Jag1Mhdahtu/Jag1Mhdahtu
Genetic
Background
C3HeB/FeJ-Jag1Mhdahtu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Mhdahtu mutation (2 available); any Jag1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Jag1Mhdahtu/Jag1Mhdahtu mice die because of defects in vascular remodeling

mortality/aging

growth/size/body
• almost all E11.5 embryos appear to be delayed in development by a day or half a day

embryo
• absence or great reduction in the number of large blood vessels in the yolk sacs
• almost all E11.5 embryos appear to be delayed in development by a day or half a day
• some embryos exhibit a kinky neural tube

cardiovascular system
• less branching of vessels in the head region
• absence or great reduction in the number of large blood vessels in the yolk sacs
• some embryos exhibit an expanded pericardium
• hemorrhage

nervous system
• some embryos exhibit a kinky neural tube




Genotype
MGI:3717461
ht2
Allelic
Composition
Jag1Mhdahtu/Jag1+
Genetic
Background
C3HeB/FeJ-Jag1Mhdahtu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Mhdahtu mutation (2 available); any Jag1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Inner ear of Jag1Mhdahtu/Jag1+ mice at E16.5 shows missing or smaller ampullae

behavior/neurological
• mild head shaking behavior
• age of onset is approximately weaning age

hearing/vestibular/ear
N
• mutants are not deaf and have normal endocochlear potentials, but have slightly, although not significant, raised thresholds for compound action potentials
• display atypical hair cells that exhibit the bundle morphology of outer hair cells but reside in the inner hair cell row, resulting in an overall increases in the number of inner hair cells by 17%
• 33% reduction in the numbers of outer hair cells; instead of the normal 3 rows of outer hair cells there are only 2 rows and in some regions, only one row
• the number of inner hair cells is increased slightly, with occasional cells appearing in a second row toward the inner sulcus
• truncation of semicircular canals
• posterior and sometimes anterior ampullae are missing; most mice have both ampullae missing
• when present, the anterior ampulla is small
• in the few cases where the posterior ampulla is present, it is very small
• anterior crista at P3 is small, flat and missing eminentia cruciata (J:72108)
• mice lack anterior cristae and sometime posterior cristae unlike in wild-type mice (J:149467)

nervous system
• display atypical hair cells that exhibit the bundle morphology of outer hair cells but reside in the inner hair cell row, resulting in an overall increases in the number of inner hair cells by 17%
• 33% reduction in the numbers of outer hair cells; instead of the normal 3 rows of outer hair cells there are only 2 rows and in some regions, only one row
• the number of inner hair cells is increased slightly, with occasional cells appearing in a second row toward the inner sulcus

Mouse Models of Human Disease
OMIM ID Ref(s)
Alagille Syndrome 1; ALGS1 118450 J:72108




Genotype
MGI:3717465
ht3
Allelic
Composition
Jag1Mhdahtu/Jag1Slalom
Genetic
Background
involves: BALB/c * C3H * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Mhdahtu mutation (2 available); any Jag1 mutation (35 available)
Jag1Slalom mutation (2 available); any Jag1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• absence of blood vessels in the yolk sac
• embryos are either necrotic or hemorrhagic

cardiovascular system
• absence of blood vessels in the yolk sac
• embryos are either necrotic or hemorrhagic




Genotype
MGI:3849174
cx4
Allelic
Composition
Jag1Mhdahtu/Jag1+
Six1Cwe/Six1+
Genetic
Background
C3HeB/FeJ-C3HeB/FeJ-Jag1Htu Six1Cwe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Mhdahtu mutation (2 available); any Jag1 mutation (35 available)
Six1Cwe mutation (1 available); any Six1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• anterior and posterior canals are truncated compared to in wild-type mice
• however, lateral canals are normal
• mice lack cristae unlike wild-type mice

behavior/neurological





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory