Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a1tm1Hten mutation
(1 available);
any
Slc34a1 mutation
(39 available)
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growth/size/body
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• significantly reduced body weight at birth
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• significantly reduced body weight at 12 weeks of age
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homeostasis/metabolism
renal/urinary system
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• renal inorganic phosphate wasting
• improves with age
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• mineral deposition in kidneys at 12 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a1tm1Hten mutation
(1 available);
any
Slc34a1 mutation
(39 available)
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Histological appearance of bone from wild-type, Slc34a1tm1Hten/Slc34a1+ and Slc34a1tm1Hten/Slc34a1tm1Hten mice
mortality/aging
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• 44% of homozygotes die before or at weaning
• death is attributed to poor nutritional status
• homozygotes that survive weaning appear normal thereafter, despite smaller size and lower body weight
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behavior/neurological
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• homozygotes display some lethargy during the first 2 weeks of life
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• homozygotes frequently have difficulties in feeding during the first 2 weeks of life
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growth/size/body
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• at birth, homozygotes are noticeably smaller than wild-type littermates
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• at birth, homozygotes exhibit a significantly reduced body weight relative to wild-type controls (1.49 0.08 g vs 1.89 0.12 g)
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• homozygotes remain significantly smaller than wild-type littermates for at least 4 months after birth
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• homozygotes maintain a significantly lower body weight for at least 4 months after birth
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homeostasis/metabolism
renal/urinary system
N |
• homozygotes show no evidence for amino aciduria, glycosuria, or proteinuria, indicating that the renal inorganic phosphate leak is not due to a generalized tubulopathy
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• at 1 month of age, the urine calcium/creatinine ratio and the fractional excretion index for calcium (FEICa) are significantly increased
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• at 1 month of age, the urine Pi/creatinine ratio and the fractional excretion index for Pi (FEIPi) are strikingly increased
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skeleton
N |
• homozygotes do not exhibit rickets or osteomalacia
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• poor initial development of cancellous bone
• by 45 days of age, the number metaphyseal trabeculae exceeded that in wild-type
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• initial impairment of secondary ossification in the epiphysis observed at 21 days of age
• by 45 days of age, the skeletal phenotype had reversed and overcompensated
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muscle
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• homozygotes display apparent muscle weakness during the first 2 weeks of life
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reproductive system
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• homozygotes display reduced reproductive ability relative to wild-type and heterozygous controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a1tm1Hten mutation
(1 available);
any
Slc34a1 mutation
(39 available)
Slc34a3tm1Kimi mutation
(0 available);
any
Slc34a3 mutation
(24 available)
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growth/size/body
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• marked growth retardation
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homeostasis/metabolism
renal/urinary system
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• abnormal phosphate re-uptake
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• significantly elevated calcium levels in urine
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• mineral deposition in kidneys
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skeleton
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• irregularly arranged metaphyseal trabecules
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• deep growth plate cartilage
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• reduced mineralization of trabecules
• significantly increased osteoid volume/bone volume
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• develop typical features of rickets
• rescued by a high phosphate diet
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