Phenotypes associated with this allele
vision/eye
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• scotopic electroretinogram recordings in response to 20 msec white light flashes in dark-adapted mutants showed that b-wave amplitudes were 40% smaller than in wild-type controls but a-waves did not differ, indicating a defect in the rod driven circuitry
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Kwi mutation
(1 available);
any
Gjc1 mutation
(33 available)
Tg(Myh6-icre/ERT2)#Wet mutation
(0 available)
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mortality/aging
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• embryos treated with tamoxifen at E8.5 and E9.5 die beyond E10.5
• however, mice not treated with tamoxifen develop normally
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cardiovascular system
N |
• tamoxifen-treated mice do not exhibit spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia
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• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval compared with control mice
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• in tamoxifen-treated mice
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• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Kwi mutation
(1 available);
any
Gjc1 mutation
(33 available)
Gjd3tm2.1Kwi mutation
(1 available);
any
Gjd3 mutation
(13 available)
Tg(Myh6-icre/ERT2)#Wet mutation
(0 available)
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mortality/aging
N |
• tamoxifen-treated mice are viable
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cardiovascular system
N |
• tamoxifen-treated mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia
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• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval and Wenckebach periodicity compared with control mice
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• in tamoxifen-treated mice
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• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice
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