Phenotypes associated with this allele

• Allele Symbol: Hif1a^tm2Rsjo
• Allele Name: targeted mutation 2, Randall S Johnson
• Allele ID: MGI:2385361
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hif1a^tm2Rsjo/Hif1a^tm2Rsjo	involves: 129S1/Sv * 129X1/SvJ	MGI:3621464

Genotype
MGI:3621464

hm1

• Allelic Composition: Hif1a^tm2Rsjo/Hif1a^tm2Rsjo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal dorsal aorta morphology ( J:48084 )

• the dorsal aorta is present but reduced in size

decreased angiogenesis ( J:48084 )

• at E9.5 few capillaries and no vascular network are present in the neural folds and the intersomitic vasculature is interrupted

disorganized yolk sac vascular plexus ( J:48084 )

• at E9.5, complete lack of organized branching although fully formed vessels and red blood cells are present

homeostasis/metabolism

hypoxia ( J:48084 )

• striking increase in hypoxia especially in the neural ectoderm and somites

cellular

increased embryonic tissue cell apoptosis ( J:48084 )

• increase in the interior of the embryo

embryo

disorganized yolk sac vascular plexus ( J:48084 )

• at E9.5, complete lack of organized branching although fully formed vessels and red blood cells are present

increased embryonic tissue cell apoptosis ( J:48084 )

• increase in the interior of the embryo

decreased embryo size ( J:48084 )

• starting at E8.0 and becoming more severe by E9.5

abnormal neural fold formation ( J:48084 )

• at E8.0. reduced and somewhat convoluted neural folds are seen

• at E8.5 and E9.5, the neural folds are abnormal and not completely closed

• at E9.5 few capillaries and no vascular network are present in the neural folds

abnormal somite development ( J:48084 )

• at E8.5, fewer somites are present

growth/size/body

decreased embryo size ( J:48084 )

• starting at E8.0 and becoming more severe by E9.5