Phenotypes associated with this allele

• Allele Symbol: Gfap^tm4Ito
• Allele Name: targeted mutation 4, Shigeyoshi Itohara
• Allele ID: MGI:2384721
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfap^tm4Ito/Gfap^tm4Ito	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3790658
cx2	Gfap^tm4Ito/Gfap^tm4Ito Vim^tm1Cba/Vim^tm1Cba	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6)	MGI:3790659

Genotype
MGI:3790658

hm1

• Allelic Composition: Gfap^tm4Ito/Gfap^tm4Ito
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS glial cell morphology ( J:78341 )

• cultured E18.5 neurons have glial fibrillary acidic protein-immunoreactive filaments in astrocytes are sparse, irregularly arrayed, and sometimes disrupted

abnormal astrocyte morphology ( J:78341 )

• decreased glial fibrillary acidic protein (GFAP) immunoreactivity is more severe than in Gfap-single mutants

Genotype
MGI:3790659

cx2

• Allelic Composition: Gfap^tm4Ito/Gfap^tm4Ito; Vim^tm1Cba/Vim^tm1Cba
• Genetic Background: either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6)

nervous system

abnormal CNS glial cell morphology ( J:78341 )

• decreased glial fibrillary acidic protein (GFAP) immunoreactivity is more severe than in Gfap-single mutants

abnormal astrocyte morphology ( J:78341 )

• cultured E18.5 neurons have glial fibrillary acidic protein-immunoreactive filaments in astrocytes are sparse, irregularly arrayed, and sometimes disrupted

• dot-like aggregate structures appear in cultured E18.5 astrocytes