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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(UPII-SV40T)2Xrw
transgene insertion 2, Xue-Ru Wu
MGI:2384608
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(UPII-SV40T)2Xrw/0 involves: FVB/N MGI:5141744


Genotype
MGI:5141744
tg1
Allelic
Composition		 Tg(UPII-SV40T)2Xrw/0
Genetic
Background		 involves: FVB/N
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased urinary bladder carcinoma incidence ( J:56305 )
• mutants succumb to bladder cancer at 3 months of age, developing patches of bladder carcinoma in situ (CIS)
increased urinary bladder transitional cell carcinoma incidence ( J:56305 )
• mutants also develop moderately differentiated transitional cell carcinoma (TCC) that invades into the detrusor muscle layer

renal/urinary system
increased urinary bladder carcinoma incidence ( J:56305 )
• mutants succumb to bladder cancer at 3 months of age, developing patches of bladder carcinoma in situ (CIS)
increased urinary bladder transitional cell carcinoma incidence ( J:56305 )
• mutants also develop moderately differentiated transitional cell carcinoma (TCC) that invades into the detrusor muscle layer

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
urinary bladder cancer DOID:11054 OMIM:109800
 J:56305




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory