About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irak1tm1Jth
targeted mutation 1, James A Thomas
MGI:2384212
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irak1tm1Jth/Irak1tm1Jth B6.Cg-Irak1tm1Jth MGI:3584387
cx2
 		Irak1tm1Jth/Y
Irak2tm1Aki/Irak2tm1Aki 		involves: 129/Sv * C57BL/6 MGI:3807961
cx3
 		Irak1tm1Jth/Irak1tm1Jth
Tg(Myh6-Tnf)1Brgi/? 		involves: 129/Sv * C57BL/6J * SJL MGI:3586620
cx4
 		Irak1tm1Jth/Y
Tg(Myh6-Tnf)1Brgi/? 		involves: 129/Sv * C57BL/6J * SJL MGI:3586621
ot5
 		Irak1tm1Jth/Y B6.Cg-Irak1tm1Jth MGI:3586624


Genotype
MGI:3584387
hm1
Allelic
Composition		 Irak1tm1Jth/Irak1tm1Jth
Genetic
Background		 B6.Cg-Irak1tm1Jth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Jth mutation (0 available); any Irak1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:82302 )
• almost completely resistant to experimental autoimmune encephalomyelitis induced by injection of myelin oligodendrocyte glycoprotein
• T cells failed to respond to antigen early but response after about 1 month was normal as was Ifn-gamma production
• reduced macrophage infiltration into central nervous system




Genotype
MGI:3807961
cx2
Allelic
Composition		 Irak1tm1Jth/Y
Irak2tm1Aki/Irak2tm1Aki
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Jth mutation (0 available); any Irak1 mutation (16 available)
Irak2tm1Aki mutation (0 available); any Irak2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:136290 )
• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type
abnormal dendritic cell physiology ( J:136290 )
• cytokine production in response to TLR ligands such as LPS or CpG DNA is defective
decreased susceptibility to endotoxin shock ( J:136290 )
• after challenge with LPS or CpG DNA together with D-galactosamine, no mutants died in contrast to 100% mortality of wild-type to endotoxic shock

hematopoietic system
abnormal macrophage physiology ( J:136290 )
• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type




Genotype
MGI:3586620
cx3
Allelic
Composition		 Irak1tm1Jth/Irak1tm1Jth
Tg(Myh6-Tnf)1Brgi/?
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Jth mutation (0 available); any Irak1 mutation (16 available)
Tg(Myh6-Tnf)1Brgi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:84829 )
N
• mice survived past 150 days of age

cardiovascular system
abnormal heart morphology ( J:84829 )
• only in about 10% of mice, otherwise normal
myocardial fiber degeneration ( J:84829 )
• cardiac myocytes undergoing degenerative changes
myocarditis ( J:84829 )
• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts

immune system
myocarditis ( J:84829 )
• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts

muscle
myocardial fiber degeneration ( J:84829 )
• cardiac myocytes undergoing degenerative changes




Genotype
MGI:3586621
cx4
Allelic
Composition		 Irak1tm1Jth/Y
Tg(Myh6-Tnf)1Brgi/?
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Jth mutation (0 available); any Irak1 mutation (16 available)
Tg(Myh6-Tnf)1Brgi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:84829 )
N
• mice survived past 150 days of age

cardiovascular system
abnormal heart morphology ( J:84829 )
• only in about 10% of mice, otherwise normal
myocardial fiber degeneration ( J:84829 )
• cardiac myocytes undergoing degenerative changes
myocarditis ( J:84829 )
• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts

immune system
myocarditis ( J:84829 )
• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts

muscle
myocardial fiber degeneration ( J:84829 )
• cardiac myocytes undergoing degenerative changes




Genotype
MGI:3586624
ot5
Allelic
Composition		 Irak1tm1Jth/Y
Genetic
Background		 B6.Cg-Irak1tm1Jth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Jth mutation (0 available); any Irak1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:82302 )
• almost completely resistant to experimental autoimmune encephalomyelitis induced by injection of myelin oligodendrocyte glycoprotein
• T cells failed to respond to antigen early but response after about 1 month was normal as was Ifn-gamma production
• reduced macrophage infiltration into central nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory