Analysis Tools
behavior/neurological
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• in the elevated plus maze, mutant mice spend significantly less time in the open arms than do control littermates, and mutant mice also enter the open arms fewer times than do controls; overall activity in closed-arm entries and total arm entries is not different between the mutant and control mice
• however, in the light/dark emergence test, no detectable differences are seen between mutant and control mice; the mutant mice had as many transitions between the light and dark portions of the box as did wildtype controls
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• in the open-field test, mutant mice show greater anxiety-like behavior, spending less time
in the inner squares than controls
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hearing/vestibular/ear
| N |
• in mutant mice, the organ of Corti appeared grossly normal
• no gross qualitative differences in the number of nerve terminals contacting the outer hair cells or present in the inner spiral bundle, or in the expression of CGRP and vesicular Ach transporter
in the terminals in mutant mice compared with littermate controls at three
months of age
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• outer hair-cell length is smaller in mutant mice compared to controls (wild type, 13.8 angstroms, 0.6 microm; mutant mice, 12.4 angstroms, 0.3 microm; P < 0.05)
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• at all frequencies, the mutant mice consistently showed a higher threshold for the stimuli than control littermates at both 3 and 6 months of age
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• distortion-product otoacoustic emissions are higher in mutant mice at all ages tested; however, there is no significant change in the level of distortion products within a genotype pool in relation to age (3 vs. 6 months of age)
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homeostasis/metabolism
| N |
• after acute restraint, stress hormone secretion profiles, including ACTH and corticosterone, of mutant mice do not differ from those of control littermates
• daily basal food intake of Ucn mutants of both sexes as well as food intake and body weight in response to 24 hours of food deprivation is similar in both mutant and control mice
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nervous system
| N |
• cresyl violet (Nissl) staining of brain sections show no apparent cytoarchitectural abnormalities in mutant mice
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• outer hair-cell length is smaller in mutant mice compared to controls (wild type, 13.8 angstroms, 0.6 microm; mutant mice, 12.4 angstroms, 0.3 microm; P < 0.05)
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