Ucn^tm1Klee
Targeted Allele Detail

Summary

• Symbol: Ucn^tm1Klee
• Name: urocortin; targeted mutation 1, Kuo-Fen Lee
• MGI ID: MGI:2384136
• Synonyms: Ucn^-
• Gene: Ucn Location: Chr5:31295407-31296173 bp, - strand Genetic Position: Chr5, 17.11 cM
• Alliance: Ucn^tm1Klee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78199
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region encoding the mature peptide was deleted by the insertion of a neomycin selection cassette. The absence of transcript in homozygous mutant mice was demonstrated by RNAse protection and in situ hybridization. Western blot analysis of brain tissue confirmed the lack of protein. (J:78199)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucn Mutation: 4 strains or lines available

References

• Original: J:78199 Vetter DE, et al., Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet. 2002 Aug;31(4):363-9
• All: 6 reference(s)