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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fggtm1Fjc
targeted mutation 1, Francis J Castellino
MGI:2384029
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fggtm1Fjc/Fggtm1Fjc involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3662854
cx2
Apobec1tm1Ddsn/Apobec1tm1Ddsn
Fggtm1Fjc/Fggtm1Fjc
Ldlrtm1Her/Ldlrtm1Her
B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her MGI:4367109


Genotype
MGI:3662854
hm1
Allelic
Composition
Fggtm1Fjc/Fggtm1Fjc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fggtm1Fjc mutation (0 available); any Fgg mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• ~25% of newborn homozygotes suffer from primarily abdominal hemorrhages, although hemorrhages around the cranial, neck, and nasal areas are also observed
• however, many homozygotes are able to resolve the bleeding and recover
• ~25% of newborn homozygotes suffer from primarily abdominal hemorrhages
• pregnant female homozygotes consistently present with various degrees of vaginal bleeding beginning at E7
• excessive maternal bleeding is detected at the implantation site in the uterus as early as E6

homeostasis/metabolism
• homozygotes exhibit significantly delayed thrombin-induced plasma clot times (>17 min) relative to wild-type mice (35.5 3.5 sec)

reproductive system
• pregnant female homozygotes consistently present with various degrees of vaginal bleeding beginning at E7
• excessive maternal bleeding is detected at the implantation site in the uterus as early as E6
• at E6, embryos in the uteri of pregnant female homozygotes show severe bleeding in regions around the ectoplacental cone, resulting in blood-filled lacunae at E8 to E9
• by E9 large areas of bleeding initiate the disruption of the placenta and yolk sac from the endometrium
• pregnant female homozygotes undergo spontaneous abortion, with resulting maternal death at E9.75 through excessive bleeding
• a minimal dosage schedule of 10 mg of fibrinogen at E8.5 and E17.5 rescues pregnancy and results in successful vaginal deliveries

embryo
• at E9.75, embryos obtained from female pregnant homozygotes are significantly smaller and show bleeding in the egg cylinder cavity
• at E9.75, placental detachment occurs from the implantation site
• afibrinogenemic pregnant females show detachment of the fibrinoid layer from the decidua and disruption of sinusoids of the labyrinths with severe hemorrhage along the planes of placental-decidual attachment
• at E9, embryos obtained from pregnant female homozygotes display a smaller placenta
• at E9.75, embryos obtained from female pregnant homozygotes display a significantly smaller yolk sac
• female homozygotes exhibit abnormal development of fetal-maternal vascular communication and stabilization of embryo implantation

growth/size/body
• at E9.75, embryos obtained from female pregnant homozygotes are significantly smaller and show bleeding in the egg cylinder cavity

respiratory system
N
• in response to bleomycin-induced acute lung injury, homozygotes show no significant differences in the deposition of interstitial collagen and pulmonary fibrotic lesions at 7 and 14 days after intratracheal administration of bleomycin relative to wild type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Afibrinogenemia, Congenital 202400 J:75302




Genotype
MGI:4367109
cx2
Allelic
Composition
Apobec1tm1Ddsn/Apobec1tm1Ddsn
Fggtm1Fjc/Fggtm1Fjc
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1tm1Ddsn mutation (0 available); any Apobec1 mutation (12 available)
Fggtm1Fjc mutation (0 available); any Fgg mutation (8 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• display better survival to 3 weeks than do mice only deficient for Fgg

homeostasis/metabolism
• cholesterol is primarily in the LDL fraction as opposed to controls where it is predominantly in the HDL fraction
• thrombin and antithrombin levels very highly elevated

cardiovascular system
• plaque surface area increases beyond what is seen in double homozygotes lacking fibrinogen gamma chain deficiency
• fibrous cap thinner than is seen in double homozygotes lacking fibrinogen gamma chain deficiency
• collagen deposition in plaques develops more rapidly than in double homozygotes lacking fibrinogen gamma chain deficiency





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory