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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ets1tm1Jml
targeted mutation 1, Jeffrey M Leiden
MGI:2182789
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ets1tm1Jml/Ets1tm1Jml involves: 129S/SvEv * C57BL/6 MGI:3833458
cn2
Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353414
cn3
Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0
involves: 129S/SvEv * C57BL/6 * FVB/N MGI:4353416
cx4
Ets1tm1Jml/Ets1tm1Jml
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J MGI:3833459
cx5
Ets1tm1Jml/Ets1tm1Jml
Ets2tm2Rgo/Ets2tm2Rgo
involves: 129S/SvEv * C57BL/6 * FVB/N MGI:4353402


Genotype
MGI:3833458
hm1
Allelic
Composition
Ets1tm1Jml/Ets1tm1Jml
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the development of single positive T cells in the thymus is skewed away from CD8+ T cells compared to in wild-type mice
• however, no skewing was observed in peripheral tissues indicating adequate seeding of peripheral tissues or homeostatic expansion
• defective D8+ T cell differentiation is thymocyte intrinsic as determined by transplant assays
• without a change in NK1.1 expression
• the number of single positive CD4+ T cells is decreased in lymph nodes and slightly decreased in the spleen compared to in wild-type mice
• the number of single positive CD8+ T cells is decreased in the thymus and lymph nodes and slightly decreased in the spleen compared to in wild-type mice

hematopoietic system
• the development of single positive T cells in the thymus is skewed away from CD8+ T cells compared to in wild-type mice
• however, no skewing was observed in peripheral tissues indicating adequate seeding of peripheral tissues or homeostatic expansion
• defective D8+ T cell differentiation is thymocyte intrinsic as determined by transplant assays
• without a change in NK1.1 expression
• the number of single positive CD4+ T cells is decreased in lymph nodes and slightly decreased in the spleen compared to in wild-type mice
• the number of single positive CD8+ T cells is decreased in the thymus and lymph nodes and slightly decreased in the spleen compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:4353414
cn2
Allelic
Composition
Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (15 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (28 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between E11.5 and E15.5

cardiovascular system
• seen at E11.5 in some embryos

homeostasis/metabolism
• seen at E11.5 in some embryos




Genotype
MGI:4353416
cn3
Allelic
Composition
Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (15 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (28 available)
Tg(Tek-cre)1Ywa mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cellular
• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system
• defect in branching seen at E10.5 and E11.5
• increase in inter blood vessel spacing
• increase in endothelial cell apoptosis at E11.5 and E13.5




Genotype
MGI:3833459
cx4
Allelic
Composition
Ets1tm1Jml/Ets1tm1Jml
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (15 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:4353402
cx5
Allelic
Composition
Ets1tm1Jml/Ets1tm1Jml
Ets2tm2Rgo/Ets2tm2Rgo
Genetic
Background
involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (15 available)
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected embryos are seen at E11.5 with all lost before E15.5
• fewer than expected embryos are seen at E11.5 with all lost before E15.5

cellular
• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system
• striking decrease in vascular complexity at E10.5
• defect in branching is also seen at E9.5 and E11.5
• increase in inter blood vessel spacing
• dilation is often seen at E10.5 with the distinction between large and small vessels unclear
• at E11.5, some embryos have large visibly dilated blood vessels
• seen at E11.5 in some embryos
• increase in endothelial cell apoptosis at E11.5 and E13.5

homeostasis/metabolism
• seen at E11.5 in some embryos

embryo
N
• in embryos without visible vascular abnormalities, no defects are detected in the placental labyrinth layer





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory