All Phenotypes Ung<tm1Tld> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ung^tm1Tld
targeted mutation 1, Tomas Lindahl
MGI:2182610

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ung^tm1Tld/Ung^tm1Tld	involves: 129 * C57BL/6J	MGI:3038833
hm2	Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd	MGI:4429643
hm3	Ung^tm1Tld/Ung^tm1Tld	Not Specified	MGI:3038834
cx4	Pcna^tm1Jcbs/Pcna^tm1Jcbs Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd	MGI:4429642
cx5	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5505261
cx6	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5505262
cx7	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5507885
cx8	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5507886

Allelic Composition	Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:63056 )

• no overt phenotype up to one year; fertile and developed normally

• tumor free until 12 - 18 months

• detailed histopathology of male and female mice at 1 year showed no gross abnormalities

Allelic Composition	Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased sensitivity to induced cell death ( J:197809 )

• mouse embryonic fibroblasts exhibit increased susceptibility to 5-hydroxymethyluridine and 5-fluorouracil toxicity compared with wild-type cells

abnormal base-excision repair ( J:197809 )

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

hematopoietic system

abnormal class switch recombination ( J:306598 )

• reduced IgG1 class switch recombination

abnormal somatic hypermutation frequency ( J:155454 )

• mice exhibit a marginal increase in germinal center B cell mutation frequency compared with wild-type mice

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

immune system

abnormal class switch recombination ( J:306598 )

• reduced IgG1 class switch recombination

abnormal somatic hypermutation frequency ( J:155454 )

• mice exhibit a marginal increase in germinal center B cell mutation frequency compared with wild-type mice

Allelic Composition	Ung^tm1Tld/Ung^tm1Tld
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:85353 )

• increased mortality after 18 months of age, with decreased median life span compared to controls

neoplasm

increased B cell derived lymphoma incidence ( J:85353 )

• palpable in spleen and mesenteric lymph nodes of 12% of the mice after 18 months of age

hematopoietic system

enlarged thymus ( J:85353 )

• apparent after 18 months of age

enlarged spleen ( J:85353 )

• apparent after 18 months of age

spleen hyperplasia ( J:85353 )

• apparent after 18 months of age

abnormal class switch recombination ( J:79590 )

• altered isotype balance; class switching after LPS stimulation was diminished, but not as a result of lack of B cell proliferation

decreased IgG3 level ( J:79590 )

• only IgG3 decreased

increased IgM level ( J:79590 )

• altered isotype balance

• class switching after LPS stimulation was diminished, but not as a result of lack of B cell prolferation

immune system

enlarged thymus ( J:85353 )

• apparent after 18 months of age

enlarged spleen ( J:85353 )

• apparent after 18 months of age

spleen hyperplasia ( J:85353 )

• apparent after 18 months of age

abnormal class switch recombination ( J:79590 )

• altered isotype balance; class switching after LPS stimulation was diminished, but not as a result of lack of B cell proliferation

decreased IgG3 level ( J:79590 )

• only IgG3 decreased

increased IgM level ( J:79590 )

• altered isotype balance

• class switching after LPS stimulation was diminished, but not as a result of lack of B cell prolferation

enlarged lymph nodes ( J:85353 )

• apparent after 18 months of age

lymphoid hyperplasia ( J:85353 )

• apparent after 18 months of age

endocrine/exocrine glands

enlarged thymus ( J:85353 )

• apparent after 18 months of age

growth/size/body

enlarged spleen ( J:85353 )

• apparent after 18 months of age

spleen hyperplasia ( J:85353 )

• apparent after 18 months of age

Allelic Composition	Pcna^tm1Jcbs/Pcna^tm1Jcbs Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcna^tm1Jcbs mutation (0 available); any Pcna mutation (16 available)
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal somatic hypermutation frequency ( J:155454 )

• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcna^tm1Jcbs homozygotes

immune system

abnormal somatic hypermutation frequency ( J:155454 )

• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcna^tm1Jcbs homozygotes

Allelic Composition	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_C05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smug1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Smug1 mutation (14 available)
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N	• mice exhibit normal life expectancy

cellular

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

Allelic Composition	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_C05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Smug1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Smug1 mutation (14 available)
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:197809 )

• mean life expectancy is 107 days compared with 223 days for Msh2^tm1Htr homozygotes

preweaning lethality, incomplete penetrance ( J:197809 )

• fewer than expected mice are identified at weaning

neoplasm

increased tumor incidence ( J:197809 )

• in all mice that die

increased lymphoma incidence ( J:197809 )

• in 4 of 5 mice with tumors

Allelic Composition	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_B07

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N	• mice exhibit normal life expectancy

cellular

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

Allelic Composition	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_B07

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:197809 )

• mean life expectancy is 107 days compared with 223 days for Msh2^tm1Htr homozygotes

preweaning lethality, incomplete penetrance ( J:197809 )

• fewer than expected mice are identified at weaning

neoplasm

increased tumor incidence ( J:197809 )

• in all mice that die

increased lymphoma incidence ( J:197809 )

• in 4 of 5 mice with tumors

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