All Phenotypes Dmtf1<tm1Cjs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dmtf1^tm1Cjs
targeted mutation 1, Charles J Sherr
MGI:2182441

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs	involves: 129/Sv * C57BL/6	MGI:3692580
ht2	Dmtf1^tm1Cjs/Dmtf1⁺	involves: 129/Sv * C57BL/6	MGI:3692581
cx3	Dmtf1^tm1Cjs/Dmtf1⁺ Kras^tm2Tyj/Kras⁺	involves: 129S2/SvPas * C57BL/6	MGI:3770615
cx4	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs Kras^tm2Tyj/Kras⁺	involves: 129S2/SvPas * C57BL/6	MGI:3770616
cx5	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs Kras^tm3Tyj/Kras⁺	involves: 129S4/SvJae * C57BL/6	MGI:3770618
cx6	Dmtf1^tm1Cjs/Dmtf1⁺ Kras^tm3Tyj/Kras⁺	involves: 129S4/SvJae * C57BL/6	MGI:3770617
cx7	Dmtf1^tm1Cjs/Dmtf1⁺ Tg(IghMyc)22Bri/0	involves: 129/Sv * C57BL * C57BL/6 * SJL	MGI:3692583

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1^tm1Cjs mutation (3 available); any Dmtf1 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:63444 )

• normal numbers of homozygotes at E13.5

• reduced frequency of homozygotes at 3 weeks of age

• about 1/3 of those born die within the first 3 weeks of life

growth/size/body

decreased birth body size ( J:63444 )

• small at birth

postnatal growth retardation ( J:63444 )

• development after birth is slow, particularly for males

• female weights between 3 and 8 weeks of age are similar to controls while males remain small

behavior/neurological

absent gastric milk in neonates ( J:63444 )

• mice that die in the first 3 weeks of life characteristically lack milk in their stomachs

limb grasping ( J:63444 )

• about 10% exhibit an abnormal clasping reflex when lifted by their tails

seizures ( J:63444 )

renal/urinary system

abnormal renal/urinary system morphology ( J:63444 )

• chronic obstructive uropathy in about 1/3 of males

distended urinary bladder ( J:63444 )

reproductive system

abnormal male reproductive system morphology ( J:63444 )

• genital swelling in about 1/3 of males

dilated seminal vesicle ( J:63444 )

• dilated

immune system

decreased thymocyte number ( J:63444 )

• 35% as many thymocytes found as in controls

abnormal T cell physiology ( J:63444 )

• T lymphocytes have a higher proliferative capacity than controls

neoplasm

increased tumor incidence ( J:63444 , J:72617 )

• low but elevated tumor incidence in the first year (J:63444)

• wide variety of tumor types (J:63444)

• spontaneous lethal tumors develop with a high level of frequency in the second year of life, mean latency 83 weeks (J:72617)

increased incidence of induced tumors ( J:63444 )

• very susceptible to tumor induction by either ionizing radiation or dimethylbenzanthracene

endocrine/exocrine glands

decreased thymocyte number ( J:63444 )

• 35% as many thymocytes found as in controls

dilated seminal vesicle ( J:63444 )

• dilated

hematopoietic system

decreased thymocyte number ( J:63444 )

• 35% as many thymocytes found as in controls

abnormal T cell physiology ( J:63444 )

• T lymphocytes have a higher proliferative capacity than controls

nervous system

seizures ( J:63444 )

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1^tm1Cjs mutation (3 available); any Dmtf1 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:63444 , J:72617 )

• low but elevated tumor incidence in the first year (J:63444)

• wide variety of tumor types (J:63444)

• spontaneous lethal tumors develop with a high level of frequency in the second year of life, mean latency 83 weeks (J:72617)

increased incidence of induced tumors ( J:63444 )

• very susceptible to tumor induction by either ionizing radiation or dimethylbenzanthracene

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1⁺ Kras^tm2Tyj/Kras⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1^tm1Cjs mutation (3 available); any Dmtf1 mutation (83 available)
Kras^tm2Tyj mutation (1 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:126002 )

• mean survival time of double mutants is 41 weeks compared to 55 weeks for Kras^LA+/-, Dmtf1-sufficient mice

neoplasm

increased T cell derived lymphoma incidence ( J:126002 )

• ~30% of mice develop thymic lymphomas

increased skin papilloma incidence ( J:126002 )

• 20-30% of animals develop tail papillomas

increased cholangiocarcinoma incidence ( J:126002 )

• one case of cholangiocarcinoma was observed

abnormal metastatic potential ( J:126002 )

• <5% of animals show distant metastases (liver/intr-abdominal or leg) of lung tumors, while no metastases are observed in Kras^LA+/-, Dmtf1-sufficient mice

increased neurofibroma incidence ( J:126002 )

• one case of neurofibroma was observed

increased osteosarcoma incidence ( J:126002 )

• one case of osteosarcoma was observed

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

decreased tumor latency ( J:126002 )

• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice

integument

increased skin papilloma incidence ( J:126002 )

• 20-30% of animals develop tail papillomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126002 )

• ~30% of mice develop thymic lymphomas

liver/biliary system

increased cholangiocarcinoma incidence ( J:126002 )

• one case of cholangiocarcinoma was observed

skeleton

increased osteosarcoma incidence ( J:126002 )

• one case of osteosarcoma was observed

nervous system

increased neurofibroma incidence ( J:126002 )

• one case of neurofibroma was observed

respiratory system

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs Kras^tm2Tyj/Kras⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:126002 )

• mean survival time of double mutants is 36 weeks compared to 55 weeks for Kras^+/-, Dmtf1-sufficient mice

neoplasm

increased ovary tumor incidence ( J:126002 )

• one case of ovarian cystic adenoma was observed

increased T cell derived lymphoma incidence ( J:126002 )

• ~20% of mice develop thymic lymphomas

increased skin papilloma incidence ( J:126002 )

• 30-40% of animals develop tail papillomas

abnormal metastatic potential ( J:126002 )

• <5% of animals show distant metastases (liver/intr-abdominal or leg) of lung tumors, while no metastases are observed in Kras^LA+/-, Dmtf1-sufficient mice

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

decreased tumor latency ( J:126002 )

• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice

integument

increased skin papilloma incidence ( J:126002 )

• 30-40% of animals develop tail papillomas

endocrine/exocrine glands

increased ovary tumor incidence ( J:126002 )

• one case of ovarian cystic adenoma was observed

increased T cell derived lymphoma incidence ( J:126002 )

• ~20% of mice develop thymic lymphomas

reproductive system

increased ovary tumor incidence ( J:126002 )

• one case of ovarian cystic adenoma was observed

respiratory system

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1^tm1Cjs Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1^tm1Cjs mutation (3 available); any Dmtf1 mutation (83 available)
Kras^tm3Tyj mutation (2 available); any Kras mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:126002 )

• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras^+/-, Dmtf1-sufficient mice

neoplasm

increased T cell derived lymphoma incidence ( J:126002 )

• ~20% of mice develop thymic lymphomas

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

increased lung tumor incidence ( J:126002 )

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

decreased tumor latency ( J:126002 )

• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice

integument

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126002 )

• ~20% of mice develop thymic lymphomas

respiratory system

increased lung tumor incidence ( J:126002 )

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1⁺ Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:126002 )

• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras^+/-, Dmtf1-sufficient mice

neoplasm

increased T cell derived lymphoma incidence ( J:126002 )

• ~35% of mice develop thymic lymphomas

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

abnormal metastatic potential ( J:126002 )

• <5% of animals show distant metastases (liver/intr-abdominal or leg) of lung tumors, while no metastases are observed in Kras^LA+/-, Dmtf1-sufficient mice

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

decreased tumor latency ( J:126002 )

• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice

integument

increased skin papilloma incidence ( J:126002 )

• 10-20% of animals develop tail papillomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126002 )

• ~35% of mice develop thymic lymphomas

respiratory system

increased lung tumor incidence ( J:126002 )

• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion

increased lung adenoma incidence ( J:126002 )

• all mice develop lung adenomas or lung adenocarcinomas

increased lung adenocarcinoma incidence ( J:126002 )

• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in Kras^LA+/- single mutants

• number of tumor nodules increase as animals become sick, with trend to increased nodule size

Allelic Composition	Dmtf1^tm1Cjs/Dmtf1⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129/Sv * C57BL * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1^tm1Cjs mutation (3 available); any Dmtf1 mutation (83 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:72617 )

• accelerated tumor formation as compared to mice carrying only Tg(IghMyc)22Bri

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