About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgf9Eks
elbow knee synostosis
MGI:2182127
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fgf9Eks/Fgf9Eks involves: C57BL/6J * DBA/2J MGI:3840441
ht2
Fgf9Eks/Fgf9+ involves: C57BL/6J * DBA/2J MGI:3840442
ht3
Fgf9Eks/Fgf9tm1Dor involves: 129S6/SvEvTac * C57BL/6J * DBA/2J MGI:3840443


Genotype
MGI:3840441
hm1
Allelic
Composition
Fgf9Eks/Fgf9Eks
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf9Eks mutation (1 available); any Fgf9 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Skull, cochlear and axial skeleton abnormalities in Fgf9Eks/Fgf9Eks mice

mortality/aging
• mice die shortly after birth

skeleton
• the humerus and radius are fused
• the humerus and radius are fused
• ossification centers are fused in the caudal half unlike in wild-type mice
• thickened ribs
• ossification centers of vertebral bodies are flatter than in wild-type mice
• mice lack knee and elbow joints
• however, the cartilage separating the humerus and ulna is present
• the humerus and radius are fused (J:77537)
• in the cartilaginous and skeletal components of the elbow joint (J:146802)
• premature fusion of the coronal sutures (J:77537)
• premature fusion of the coronal sutures (J:146802)
• premature fusion of the sagittal sutures

respiratory system
• lungs are less branched than in wild-type mice
• mice exhibit agonal breathing

vision/eye

digestive/alimentary system
• in the secondary palate

hearing/vestibular/ear

homeostasis/metabolism

limbs/digits/tail
• the humerus and radius are fused
• the humerus and radius are fused

craniofacial
• mid-face hypoplasia
• tall forehead
• in the secondary palate

behavior/neurological
• mice do not creep after birth

growth/size/body
• mid-face hypoplasia
• tall forehead
• in the secondary palate




Genotype
MGI:3840442
ht2
Allelic
Composition
Fgf9Eks/Fgf9+
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf9Eks mutation (1 available); any Fgf9 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Kinky tail, elbow joint fusion and knee joint dysplasia in Fgf9Eks/Fgf9+ mice

mortality/aging
• severely affected mice die around weaning

skeleton
• elbow joints and eventually knee joints fuse unlike in wild-type mice
• in the cartilaginous components of the elbow joint

growth/size/body
• mice exhibit growth retardation compared to wild-type mice
• however, mice eventually catch up to wild-type mice

limbs/digits/tail




Genotype
MGI:3840443
ht3
Allelic
Composition
Fgf9Eks/Fgf9tm1Dor
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf9Eks mutation (1 available); any Fgf9 mutation (14 available)
Fgf9tm1Dor mutation (0 available); any Fgf9 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• in the cartilaginous and skeletal components of the elbow joint





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/16/2021
MGI 6.17
The Jackson Laboratory