Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn1tm2Hzo mutation
(1 available);
any
Atxn1 mutation
(50 available)
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behavior/neurological
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• in an open field and elevated plus maze
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• in a Morris water maze, escape latency is increased compared to in wild-type mice
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nervous system
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• mice exhibit decreased paired-pulse facilitation compared with wild-type mice
• however, long-term and post-tetanic potentiations are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn1tm2Hzo mutation
(1 available);
any
Atxn1 mutation
(50 available)
|
|
|
behavior/neurological
|
|
• in an open field and elevated plus maze
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nervous system
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• mice exhibit decreased paired-pulse facilitation compared with wild-type mice
• however, long-term and post-tetanic potentiations are normal
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behavior/neurological
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• in a fear conditioning assay, mice exhibit reduced freezing, especially in the test of spatial context, indicating impaired learning and memory
• however, mice show normal social behavior in the three-chamber test
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• in the elevated plus-maze test, mice spend more time in the open arm and less in the closed arm, indicating reduced anxiety
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• mice cover a greater distance at a greater speed in the open-field test
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nervous system
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• the hippocampal dentate gyrus shows decreased thickness at 20 weeks of age, however the CA1 and CA3 regions are normal
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• the number of CUX1+ neurons in layers 2-4 is reduced
• however, the corpus callosum appears normal
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• mice show reduced thickness of cortical layers 2-4 at 5 and 20 weeks of age, whereas thickness of layers 5 and 6 remains normal
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn1tm2Hzo mutation
(1 available);
any
Atxn1 mutation
(50 available)
Tg(Pcp2-ATXN1*82Q)5Horr mutation
(0 available)
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behavior/neurological
nervous system
Analysis Tools