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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pde4btm1Mct
targeted mutation 1, Marco Conti
MGI:2181444
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pde4btm1Mct/Pde4btm1Mct B6N.129P2-Pde4btm1Mct/Mmucd MGI:6695904
hm2
 		Pde4btm1Mct/Pde4btm1Mct involves: 129P2/OlaHsd MGI:3717679
hm3
 		Pde4btm1Mct/Pde4btm1Mct involves: 129P2/OlaHsd * C57BL/6 MGI:3525449
hm4
 		Pde4btm1Mct/Pde4btm1Mct involves: 129X1/SvJ * C57BL/6 MGI:3054237
cx5
 		Pde4btm1Mct/Pde4btm1Mct
Pde4dtm1Mct/Pde4d+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3525454
cx6
 		Pde4btm1Mct/Pde4btm1Mct
Pde4dtm1Mct/Pde4dtm1Mct 		involves: 129P2/OlaHsd * C57BL/6 MGI:3525453
cx7
 		Pde4btm1Mct/Pde4b+
Pde4dtm1Mct/Pde4dtm1Mct 		involves: 129P2/OlaHsd * C57BL/6 MGI:3525456


Genotype
MGI:6695904
hm1
Allelic
Composition		 Pde4btm1Mct/Pde4btm1Mct
Genetic
Background		 B6N.129P2-Pde4btm1Mct/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:304450 )
N
• RS25344-treated mice exhibit normal righting response




Genotype
MGI:3717679
hm2
Allelic
Composition		 Pde4btm1Mct/Pde4btm1Mct
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:96125 )
N
• mice respond to isoproterenol in the same way as wild-type mice do




Genotype
MGI:3525449
hm3
Allelic
Composition		 Pde4btm1Mct/Pde4btm1Mct
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:106828 )
• following LPS-induced shock, mice exhibit less mortality (27% compared to 52%) and die later (3.5 days post-treatment compared to 1.5 days post-treatment) compared to wild-type mice

immune system
impaired neutrophil chemotaxis ( J:94853 )
• chemotaxis in response to KC and macrophage-inflammatory protein-2 was reduced in homozygous mutant neutrophils compared to wild-type
impaired neutrophil recruitment ( J:94853 )
• 31% reduction in the number of neutrophils that are recruited to the lung following lipopolysaccharide (LPS) inhalation compared to wild-type and homozygous Pde4a mutants
decreased tumor necrosis factor secretion ( J:106828 )
• LPS-stimulated TNF-alpha production is decreased to 43.5+/-3.5% of that in control mice
• thioglycollate-elicited macrophages produce 52.5+/-7.8% of TNF-alpha compared with wild-type cells
• macrophages do not respond to rolipram inhibition of LPS-stimulated TNF-alpha production

cellular
impaired neutrophil chemotaxis ( J:94853 )
• chemotaxis in response to KC and macrophage-inflammatory protein-2 was reduced in homozygous mutant neutrophils compared to wild-type

hematopoietic system
impaired neutrophil chemotaxis ( J:94853 )
• chemotaxis in response to KC and macrophage-inflammatory protein-2 was reduced in homozygous mutant neutrophils compared to wild-type
impaired neutrophil recruitment ( J:94853 )
• 31% reduction in the number of neutrophils that are recruited to the lung following lipopolysaccharide (LPS) inhalation compared to wild-type and homozygous Pde4a mutants




Genotype
MGI:3054237
hm4
Allelic
Composition		 Pde4btm1Mct/Pde4btm1Mct
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased tumor necrosis factor secretion ( J:76862 )
• 90% reduction in TNF-alpha production stimulated by lipo[olysaccharide




Genotype
MGI:3525454
cx5
Allelic
Composition		 Pde4btm1Mct/Pde4btm1Mct
Pde4dtm1Mct/Pde4d+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
Pde4dtm1Mct mutation (3 available); any Pde4d mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4b mutants or in wild-type

hematopoietic system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4b mutants or in wild-type




Genotype
MGI:3525453
cx6
Allelic
Composition		 Pde4btm1Mct/Pde4btm1Mct
Pde4dtm1Mct/Pde4dtm1Mct
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
Pde4dtm1Mct mutation (3 available); any Pde4d mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:94853 )
• do not survive after birth




Genotype
MGI:3525456
cx7
Allelic
Composition		 Pde4btm1Mct/Pde4b+
Pde4dtm1Mct/Pde4dtm1Mct
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
Pde4dtm1Mct mutation (3 available); any Pde4d mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4d mutants or in wild-type

hematopoietic system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4d mutants or in wild-type




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory