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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cxcl10tm1Adl
targeted mutation 1, Andrew D Luster
MGI:2180678
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cxcl10tm1Adl/Cxcl10tm1Adl B6.129S4-Cxcl10tm1Adl MGI:3695135
hm2
Cxcl10tm1Adl/Cxcl10tm1Adl involves: 129S4/SvJae * 129X1/SvJ MGI:3695133
hm3
Cxcl10tm1Adl/Cxcl10tm1Adl involves: 129S4/SvJae * C57BL/6 MGI:3695134
cx4
Apoetm1Unc/Apoetm1Unc
Cxcl10tm1Adl/Cxcl10tm1Adl
B6.129-Cxcl10tm1Adl Apoetm1Unc MGI:4938324


Genotype
MGI:3695135
hm1
Allelic
Composition
Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic
Background
B6.129S4-Cxcl10tm1Adl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10tm1Adl mutation (2 available); any Cxcl10 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• only CCL2 levels are elevated in corneas relative to wild-type or Cxcl9-null mice after HSV-1 infection
• higher incidence and greater severity of experimental autoimmune encephalomyelitis
• increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodes
• experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days
• monocytes lymphocytes and some granulocytes are involved
• 7 days after infection (day 7 pi) with herpes simplex virus type I (HSV-1), homozygotes have significantly higher HSV-1 titers in the cornea compared to Cxcl9-null or wild-type mice
• virus shedding in the tear film is elevated at day 7 pi but not at early points relative to Cxcl9 homozygotes or wild-type controls
• mice usually succumb to infection between days 7 and 9 pi

nervous system
• experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days
• monocytes lymphocytes and some granulocytes are involved
• increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodes




Genotype
MGI:3695133
hm2
Allelic
Composition
Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10tm1Adl mutation (2 available); any Cxcl10 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA
• proliferative responses after sensitization to specific antigens is also reduced
• reduced levels of antigen specific IgG2a in serum when immunized with OVA
• secretion of IFN-gamma reduced 60%

hematopoietic system
• proliferative responses after sensitization to specific antigens is also reduced
• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA
• reduced levels of antigen specific IgG2a in serum when immunized with OVA

cellular
• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA
• proliferative responses after sensitization to specific antigens is also reduced




Genotype
MGI:3695134
hm3
Allelic
Composition
Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10tm1Adl mutation (2 available); any Cxcl10 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 25% decrease in the spleen after mouse hepatitis virus infection
• decreased CNS levels of both CD4+ and CD8+ T cells after mouse hepatitis virus infection
• decreased IFN-gamma in response to mouse hepatitis virus
• greater sensitivity to mouse hepatitis virus
• titers similar to controls after 7 days but significantly higher than controls 12 days after infection

nervous system
• level of demyelination reduced 12 days after infection with mouse hepatitis virus

hematopoietic system
• 25% decrease in the spleen after mouse hepatitis virus infection
• decreased CNS levels of both CD4+ and CD8+ T cells after mouse hepatitis virus infection

homeostasis/metabolism
• decreased IFN-gamma in response to mouse hepatitis virus




Genotype
MGI:4938324
cx4
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Cxcl10tm1Adl/Cxcl10tm1Adl
Genetic
Background
B6.129-Cxcl10tm1Adl Apoetm1Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (32 available); any Apoe mutation (134 available)
Cxcl10tm1Adl mutation (2 available); any Cxcl10 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increased incidence of death due to ruptured abdominal aorta aneurysyms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

cardiovascular system
• decrease in lesion size in the angiotensin-II induced model compared to mutant mice wild-type for Cxcl10
• display more severe morphological changes following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10
• increase in the suprarenal aortic diameter and suprarenal/thoracic to infrarenal aortic area ratios in mice infused with angiotensin-II compared to mutant mice wild-type for Cxcl10
• large aortic aneurysms with spiral dissections are seen following angiotensin-II infusion
• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms
• seen following angiotensin-II infusion
• increased incidence of death due to ruptured abdominal aorta aneurysyms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10
• large aortic aneurysms with spiral dissections are seen following angiotensin-II infusion
• increase in the incidence of grade III aneurysms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10
• seen following angiotensin-II infusion

immune system
• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice
• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

hematopoietic system
• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice
• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

cellular
• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory