All Phenotypes Cxcl10<tm1Adl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcl10^tm1Adl/Cxcl10^tm1Adl	B6.129S4-Cxcl10^tm1Adl	MGI:3695135
hm2	Cxcl10^tm1Adl/Cxcl10^tm1Adl	involves: 129S4/SvJae * 129X1/SvJ	MGI:3695133
hm3	Cxcl10^tm1Adl/Cxcl10^tm1Adl	involves: 129S4/SvJae * C57BL/6	MGI:3695134
cx4	Apoe^tm1Unc/Apoe^tm1Unc Cxcl10^tm1Adl/Cxcl10^tm1Adl	B6.129-Cxcl10^tm1Adl Apoe^tm1Unc	MGI:4938324

Allelic Composition	Cxcl10^tm1Adl/Cxcl10^tm1Adl
Genetic Background	B6.129S4-Cxcl10^tm1Adl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10^tm1Adl mutation (2 available); any Cxcl10 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:120743 )

• only CCL2 levels are elevated in corneas relative to wild-type or Cxcl9-null mice after HSV-1 infection

increased susceptibility to experimental autoimmune encephalomyelitis ( J:87076 )

• higher incidence and greater severity of experimental autoimmune encephalomyelitis

CNS inflammation ( J:87076 )

• experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days

• monocytes lymphocytes and some granulocytes are involved

• increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodes

increased susceptibility to Herpesvirales infection ( J:120743 )

• 7 days after infection (day 7 pi) with herpes simplex virus type I (HSV-1), homozygotes have significantly higher HSV-1 titers in the cornea compared to Cxcl9-null or wild-type mice

• virus shedding in the tear film is elevated at day 7 pi but not at early points relative to Cxcl9 homozygotes or wild-type controls

• mice usually succumb to infection between days 7 and 9 pi

nervous system

CNS inflammation ( J:87076 )

• experimental autoimmune encephalomyelitis involves meningeal and brain parenchyma after 15 days

• monocytes lymphocytes and some granulocytes are involved

• increased levels of IFN-gamma, Il-2 and TGF-Beta1 in lymph nodes

Allelic Composition	Cxcl10^tm1Adl/Cxcl10^tm1Adl
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10^tm1Adl mutation (2 available); any Cxcl10 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased splenocyte proliferation ( J:75584 )

• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA

• proliferative responses after sensitization to specific antigens is also reduced

decreased IgG2a level ( J:75584 )

• reduced levels of antigen specific IgG2a in serum when immunized with OVA

decreased susceptibility to type IV hypersensitivity reaction ( J:75584 )

• reduced contact hypersensitivity

decreased interferon-gamma secretion ( J:75584 )

• secretion of IFN-gamma reduced 60%

hematopoietic system

decreased splenocyte proliferation ( J:75584 )

• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA

• proliferative responses after sensitization to specific antigens is also reduced

decreased IgG2a level ( J:75584 )

• reduced levels of antigen specific IgG2a in serum when immunized with OVA

cellular

decreased splenocyte proliferation ( J:75584 )

• splenocytes display significantly reduced proliferative responses in mixed lymphocyte reactions using MHC antigens but not when using conA

• proliferative responses after sensitization to specific antigens is also reduced

Allelic Composition	Cxcl10^tm1Adl/Cxcl10^tm1Adl
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl10^tm1Adl mutation (2 available); any Cxcl10 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:75584 )

• 25% decrease in the spleen after mouse hepatitis virus infection

abnormal T cell physiology ( J:75584 )

• decreased CNS levels of both CD4+ and CD8+ T cells after mouse hepatitis virus infection

abnormal interferon level ( J:75584 )

• decreased IFN-gamma in response to mouse hepatitis virus

increased susceptibility to Hepadnaviridae infection ( J:75584 )

• greater sensitivity to mouse hepatitis virus

• titers similar to controls after 7 days but significantly higher than controls 12 days after infection

nervous system

demyelination ( J:75584 )

• level of demyelination reduced 12 days after infection with mouse hepatitis virus

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:75584 )

• 25% decrease in the spleen after mouse hepatitis virus infection

abnormal T cell physiology ( J:75584 )

• decreased CNS levels of both CD4+ and CD8+ T cells after mouse hepatitis virus infection

homeostasis/metabolism

abnormal interferon level ( J:75584 )

• decreased IFN-gamma in response to mouse hepatitis virus

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:166204 )

• increased incidence of death due to ruptured abdominal aorta aneurysyms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

cardiovascular system

decreased susceptibility to atherosclerosis ( J:166204 )

• decrease in lesion size in the angiotensin-II induced model compared to mutant mice wild-type for Cxcl10

abnormal aorta morphology ( J:166204 )

• display more severe morphological changes following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

dilated aorta ( J:166204 )

• increase in the suprarenal aortic diameter and suprarenal/thoracic to infrarenal aortic area ratios in mice infused with angiotensin-II compared to mutant mice wild-type for Cxcl10

aortic aneurysm ( J:166204 )

• large aortic aneurysms with spiral dissections are seen following angiotensin-II infusion

• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

thoracic aorta aneurysm ( J:166204 )

• seen following angiotensin-II infusion

increased susceptibility to induced aneurysm formation ( J:166204 )

• increased incidence of death due to ruptured abdominal aorta aneurysyms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

• large aortic aneurysms with spiral dissections are seen following angiotensin-II infusion

• increase in the incidence of grade III aneurysms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

hematoma ( J:166204 )

• seen following angiotensin-II infusion

immune system

impaired macrophage chemotaxis ( J:166204 )

• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice

decreased CD4-positive, alpha-beta T cell number ( J:166204 )

• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

hematopoietic system

impaired macrophage chemotaxis ( J:166204 )

• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice

decreased CD4-positive, alpha-beta T cell number ( J:166204 )

• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

cellular

impaired macrophage chemotaxis ( J:166204 )

• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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