Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
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mortality/aging
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• homozygotes survived to birth but died within the first 24 hours after birth
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endocrine/exocrine glands
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• absence of axonal projections from the paraventricular and supraoptic nuclei results in more densly packed pituicytes in the posterior lobe of the pituitary
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• average number of cells in midsagittal sections of the pituitary are reduced by about 50%
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nervous system
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• paraventricular nucleus and supraoptic nuclei are hypocellular
• magnocellular neurons are absent
• terminal differentiation of neurons in both nuclei fails
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• absence of axonal projections from the paraventricular and supraoptic nuclei results in more densly packed pituicytes in the posterior lobe of the pituitary
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• average number of cells in midsagittal sections of the pituitary are reduced by about 50%
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• hypocellular
• absence of axonal projections from the paraventricular nuclei
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• hypocellular
• absence of axonal projections from the supraoptic nuclei
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
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nervous system
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• at E18.5, the principal mammillary axonal tract appears less prominent
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Allelic Composition |
Sim1tm1Fan/Sim1+
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Genetic Background |
involves: 129/Sv * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
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adipose tissue
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• mass of brown fat was increased
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• white adipose tissue cells are histologically normal
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• increased mass of white fat due to increased number of cells
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behavior/neurological
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• food intake increased around 4-5 weeks of age
• hyperphagia persists over time
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growth/size/body
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• heterozygotes have a greater naso-anal length after 4 weeks than do controls
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• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females
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homeostasis/metabolism
nervous system
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• paraventricular nucleus and supraoptic nuclei are hypocellular
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
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growth/size/body
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• after 7 months the average weight was identical to that of mice heterozygous only for Sim1tm1Fan
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nervous system
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• paraventricular nucleus and supraoptic nuclei are hypocellular
• the phenotype is identical to that of mice heterozygous only for Sim1tm1Fan
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
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nervous system
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• at E18.5, the principal mammillary axonal tract appears thin and the mammilothalmic tract is undetectable
• most mammillary body axons are directed towards the midline with some becoming splayed and others forming a bundle that crosses the midline ventrally
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
|
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nervous system
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• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1tm1Fan alone
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
|
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nervous system
|
• at E18.5, the principal mammillary axonal tract appears less prominent similar to mice homozygous for Sim1tm1Fan alone
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim1tm1Jlmd mutation
(0 available);
any
Sim1 mutation
(52 available)
Sim2tm1Fan mutation
(0 available);
any
Sim2 mutation
(22 available)
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nervous system
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• at E11.5 mammillary body axon bundles are not detectable
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