Phenotypes associated with this allele

• Allele Symbol: Selplg^tm1Rpmc
• Allele Name: targeted mutation 1, Rodger P McEver
• Allele ID: MGI:2180375
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selplg^tm1Rpmc/Selplg^tm1Rpmc	involves: 129S1/Sv	MGI:3794996
hm2	Selplg^tm1Rpmc/Selplg^tm1Rpmc	involves: 129S1/Sv * C57BL/6J	MGI:3794993

Genotype
MGI:3794996

hm1

• Allelic Composition: Selplg^tm1Rpmc/Selplg^tm1Rpmc
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:115682 )

N • mice exhibit a normal infection susceptibility to A. phagocytophilum

abnormal chemokine secretion ( J:115682 )

• chemokine secretion in response to infection with A. phagocytophilum is greater than in wild-type mice

Genotype
MGI:3794993

hm2

• Allelic Composition: Selplg^tm1Rpmc/Selplg^tm1Rpmc
• Genetic Background: involves: 129S1/Sv * C57BL/6J

immune system

abnormal leukocyte adhesion ( J:75829 )

• tethering to E-selectin is impaired

impaired leukocyte tethering or rolling ( J:75829 , J:138731 )

• fewer leukocytes roll on E-selectin coated substrates and no leukocytes roll on P-selectin coated substrates unlike wild-type cells (J:75829)

• rolling on TNFa-treated venules is reduced compared to in wild-type venules (J:75829)

increased leukocyte cell number ( J:75829 )

increased eosinophil cell number ( J:75829 )

increased neutrophil cell number ( J:75829 )

increased lymphocyte cell number ( J:75829 )

homeostasis/metabolism

increased bleeding time ( J:138731 )

• slower clotting times

hematopoietic system

abnormal leukocyte adhesion ( J:75829 )

• tethering to E-selectin is impaired

impaired leukocyte tethering or rolling ( J:75829 , J:138731 )

• fewer leukocytes roll on E-selectin coated substrates and no leukocytes roll on P-selectin coated substrates unlike wild-type cells (J:75829)

• rolling on TNFa-treated venules is reduced compared to in wild-type venules (J:75829)

increased leukocyte cell number ( J:75829 )

increased eosinophil cell number ( J:75829 )

increased neutrophil cell number ( J:75829 )

increased lymphocyte cell number ( J:75829 )

cellular

abnormal leukocyte adhesion ( J:75829 )

• tethering to E-selectin is impaired

impaired leukocyte tethering or rolling ( J:75829 , J:138731 )

• fewer leukocytes roll on E-selectin coated substrates and no leukocytes roll on P-selectin coated substrates unlike wild-type cells (J:75829)

• rolling on TNFa-treated venules is reduced compared to in wild-type venules (J:75829)