Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
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homeostasis/metabolism
nervous system
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• following 90 min of ischemia induced by middle cerebral artery occlusion and 22.5 h of reperfusion infarct size is significantly larger in mutant males compared to wild-type male controls
• however, no differences in cerebral blood flow in the ischemic hemisphere before, during or after occlusion are detected
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behavior/neurological
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• in a Morris water maze mice show longer escape latencies on each day of testing
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
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nervous system
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• display enhanced phagocytosis of Abeta plaques in an in vitro assay using hippocampal sections from Alzheimer's disease patients
• microglia show enhanced activation and tend to aggregate around Abeta plaques when incubated with hippocampal sections from Alzheimer disease patients
• in culture primary microglial cells show some signs of an activated phenotype but do not display an increase in proliferation
• cultures of mutant microglial cells and wild-type neurons exposed to ABeta1-42 show no signs of the neurotoxicity seen when wild-type microglial cells are used
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• PGE2 and a PTGER2 agonist fail to induce changes in synaptic activity
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• in hippocampal slices at 40 and 120 min after theta burst stimulation
• LPS fails to elevate LTP at hippocampal perforant path dentate granule cell synapses
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immune system
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• display enhanced phagocytosis of Abeta plaques in an in vitro assay using hippocampal sections from Alzheimer's disease patients
• microglia show enhanced activation and tend to aggregate around Abeta plaques when incubated with hippocampal sections from Alzheimer disease patients
• in culture primary microglial cells show some signs of an activated phenotype but do not display an increase in proliferation
• cultures of mutant microglial cells and wild-type neurons exposed to ABeta1-42 show no signs of the neurotoxicity seen when wild-type microglial cells are used
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hematopoietic system
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• display enhanced phagocytosis of Abeta plaques in an in vitro assay using hippocampal sections from Alzheimer's disease patients
• microglia show enhanced activation and tend to aggregate around Abeta plaques when incubated with hippocampal sections from Alzheimer disease patients
• in culture primary microglial cells show some signs of an activated phenotype but do not display an increase in proliferation
• cultures of mutant microglial cells and wild-type neurons exposed to ABeta1-42 show no signs of the neurotoxicity seen when wild-type microglial cells are used
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Allelic
Composition |
Ptger2tm1Brey/Ptger2tm1Brey
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Genetic
Background |
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
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cardiovascular system
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• the renal afferent arteriolar responses to sulprostone and endothelin 1 are increased compared to wild-type controls
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• norepinephrine precontracted renal afferent arterioles contract rather than dilate in response to PGE2 (1 uM ) or butaprost (1 uM) exposure
• this constriction response can be reversed by angiotensisn converting enzyme inhibition
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neoplasm
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• develop fewer lung tumors following a two stage 3-methylcholanthrene and butylated hydroxytoluene protocol
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• develop smaller lung tumors following a two stage 3-methylcholanthrene and butylated hydroxytoluene protocol
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homeostasis/metabolism
muscle
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• the renal afferent arteriolar responses to sulprostone and endothelin 1 are increased compared to wild-type controls
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• norepinephrine precontracted renal afferent arterioles contract rather than dilate in response to PGE2 (1 uM ) or butaprost (1 uM) exposure
• this constriction response can be reversed by angiotensisn converting enzyme inhibition
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
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immune system
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• LPS induced cerebral oxidative damage is reduced relative to controls
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nervous system
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• LPS induced cerebral oxidative damage is reduced relative to controls
• however, kainic acid induced cerebral oxidative damage is not significantly different from wild-type controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
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reproductive system
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N |
• no defects are detected in oocyte maturation or egg fertilization, in vitro
• no defects are detected in implantation or decidualization
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• in response to superovulation induction (eCG and hCG), 2- to 8-mo-old females produce far fewer eggs relative to wild-type females
• response to a superovulation protocol is better in young females (3 weeks of age) relative to older females
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• reduced number of implantations when assessed at E5
• reduced ovulation and fertilization only about 50% regardless of male genotype
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• litter sizes from crosses of homozygous males and females were reduced
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cardiovascular system
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• 8-16 week old females with significantly increased systolic pressure
• increased systolic pressure in males as well but not statistically significant
• reversible increase in blood pressure when placed on a high salt diet
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• PGE2-dependent vasodilation effects lost
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respiratory system
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• prior treatment with PGE2 fails to reduce the responsiveness to methacholine
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immune system
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• following infection with Pseudomonas aeruginosa (PA103) bacterial counts in the right lung are lower compared to wild-type controls
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muscle
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• PGE2-dependent vasodilation effects lost
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation
(6 available)
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nervous system
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• at 12 months of age in males, indices of lipid peroxidation are reduced in the brain suggesting a decrease in oxidative stress relative to transgenic mice wild-type for Ptger2
• however, no difference is detected at 2 months of age prior to onset of plaque formation
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1Brey mutation
(4 available);
any
Ptger2 mutation
(31 available)
Tg(MMTV-PTGS2)#Thla mutation
(0 available)
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reproductive system
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N |
• unlike transgenic mice wild-type for Ptger2, 12 week old virgin females do not display precocious mammary gland development
• in contrast to transgenic mice wild-type for Ptger2, few multiparous females develop mammary gland hyperplasia
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neoplasm
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• UVR induced tumors are more erythematous and have less keratinization
• UVR induced tumors are more likely to be poorly differentiated and deeply invasive compared to tumors in wild-type mice
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• while the total number of tumors is reduced, the number of larger lesions (greater than 10 mm in diameter) is increased
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• develop about half as many tumors as wild-type mice following a 15 week escalating light dose protocol
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integument
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• after a modest UVR exposure (180 mJ/cm2) keratinocyte proliferation is significantly lower compared to wild-type controls
• however, keratinocyte proliferation following higher levels of UVR exposure is similar to wild-type controls
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Allelic
Composition |
Hrhr/Hrhr
Ptger2tm1Brey/Ptger2+
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Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 * SKH1 |
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neoplasm
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N |
• unlike mice homozygous for both alleles, mice heterozygous for Ptger2tm1Brey do not show any protection against tumor formation following a 15 week escalating light dose protocol
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integument
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• after a modest UVR exposure (180 mJ/cm2) keratinocyte proliferation is significantly lower compared to wild-type controls
• however, keratinocyte proliferation following higher levels of UVR exposure is similar to wild-type controls
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Analysis Tools