Analysis Tools
mortality/aging
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• pressure overload causes increased mortality compared to in similarly treated wild-type mice
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cardiovascular system
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• following aortic banding, left ventricular end-diastolic dimension is greater than in similarly treated wild-type mice
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• following aortic banding
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• following aortic banding, myocyte apoptosis is increased compared to in similarly treated wild-type mice
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• 14 days after aortic banding, left ventricle weight and lung weight relative to body weight increased to a greater extent than in similarly treated wild-type mice
• pressure overload induced by aortic banding causes increased mortality, congestive heart failure, left ventricular end-diastolic dimension, myocyte apoptosis, and cardiac inflammation and decreased left ventricular ejection fraction compared to in similarly treated wild-type mice
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• following a scrape wound assay, migration and invasion of aortic smooth muscle cells is inhibited compared to in similarly treated wild-type mice
• in aortic explant assays, aortic smooth muscle cells exhibit reduced migration after 10 days compared with wild-type cells
• in a transwell Matrigel-coated chamber invasion assay, aortic smooth muscle cells exhibit reduced response to FGF2, EGF, and PDGF-BB compared with similarly treated wild-type cells
• following FGF2, EGF, or PDGF-BB treatment, fewer aortic smooth muscle cells form lamellipodia compared with similarly treated wild-type cells
• however, PDGF-induced proliferation of aortic smooth muscle cells is normal and transient expression of Map3k1 restores migration and invasion of aortic smooth muscle cells
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• following ligature of arteries, neointimal growth, I-M ratios, stenotic ratios, and the number of proliferating cells in the intima are decreased compared to in similarly treated wild-type mice
• following a scrape wound assay, migration and invasion of aortic smooth muscle cells is inhibited compared to in similarly treated wild-type mice
• however, the number of proliferating cells in the arterial wall and PDGF-induced proliferation of aortic smooth muscle cells are normal
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• pressure overload causes increased congestive heart failure compared to in similarly treated wild-type mice
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• following aortic banding, multifocal inflammatory lesions in the heart are more common than in similarly treated wild-type mice
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vision/eye
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• migration of eyelid epithelial cells is defective compared to in wild-type mice
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• in 95% of mice
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cellular
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• following aortic banding, myocyte apoptosis is increased compared to in similarly treated wild-type mice
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• migration of mouse embryonic fibroblast cells in culture with 5% serum is inhibited unlike for similarly treated wild-type cells
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immune system
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• immune cell differentiation appears normal
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• following aortic banding, multifocal inflammatory lesions in the heart are more common than in similarly treated wild-type mice
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homeostasis/metabolism
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• 14 days after aortic banding, left ventricle weight and lung weight relative to body weight increased to a greater extent than in similarly treated wild-type mice
• pressure overload induced by aortic banding causes increased mortality, congestive heart failure, left ventricular end-diastolic dimension, myocyte apoptosis, and cardiac inflammation and decreased left ventricular ejection fraction compared to in similarly treated wild-type mice
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• following ligature of arteries, neointimal growth, I-M ratios, stenotic ratios, and the number of proliferating cells in the intima are decreased compared to in similarly treated wild-type mice
• following a scrape wound assay, migration and invasion of aortic smooth muscle cells is inhibited compared to in similarly treated wild-type mice
• however, the number of proliferating cells in the arterial wall and PDGF-induced proliferation of aortic smooth muscle cells are normal
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muscle
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• following aortic banding
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• following aortic banding, myocyte apoptosis is increased compared to in similarly treated wild-type mice
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• following a scrape wound assay, migration and invasion of aortic smooth muscle cells is inhibited compared to in similarly treated wild-type mice
• in aortic explant assays, aortic smooth muscle cells exhibit reduced migration after 10 days compared with wild-type cells
• in a transwell Matrigel-coated chamber invasion assay, aortic smooth muscle cells exhibit reduced response to FGF2, EGF, and PDGF-BB compared with similarly treated wild-type cells
• following FGF2, EGF, or PDGF-BB treatment, fewer aortic smooth muscle cells form lamellipodia compared with similarly treated wild-type cells
• however, PDGF-induced proliferation of aortic smooth muscle cells is normal and transient expression of Map3k1 restores migration and invasion of aortic smooth muscle cells
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