Phenotypes associated with this allele

• Allele Symbol: Foxh1^tm1Jlw
• Allele Name: targeted mutation 1, Jeffrey L Wrana
• Allele ID: MGI:2179442
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxh1^tm1Jlw/Foxh1^tm1Jlw	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3709470

Genotype
MGI:3709470

hm1

• Allelic Composition: Foxh1^tm1Jlw/Foxh1^tm1Jlw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:69594 )

• die between E9.5 and E10.5

growth/size/body

embryonic growth retardation ( J:69594 )

• embryos are slightly delayed at E6.5

decreased embryo size ( J:69594 )

abnormal anterior head development ( J:69594 )

• aberrant anterior head structures

embryo

abnormal pharyngeal arch artery morphology ( J:93034 )

• absence of well-formed aortic arch arteries in the region of the aortic sac

abnormal mesendoderm development ( J:69594 )

• marker analysis indicates that mutants fail to form axial mesendoderm and lack midline structures

embryonic growth retardation ( J:69594 )

• embryos are slightly delayed at E6.5

decreased embryo size ( J:69594 )

absent prechordal mesoderm ( J:69594 )

• embryos lack prechordal plate mesoderm

absent neural folds ( J:69594 )

• mutants fail to develop neural folds

abnormal neural plate morphology ( J:69594 )

• neural plate is flat at E8.5

• anterior neural plate structures are present but are underdeveloped

absent notochord ( J:69594 )

• notochord formation is impaired, with the majority of embryos completely lacking a notochord

abnormal anterior primitive streak morphology ( J:69594 )

• lack an anterior primitive streak

absent primitive node ( J:69594 )

• all E7.5 embryos lack a distinct node and midline

fused somites ( J:69594 )

• the somites are fused across the midline at E8.5

embryonic-extraembryonic boundary constriction ( J:69594 )

• pinching in/constriction at the extraembryonic-embryonic junction is observed in about 25% of embryos

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:93034 )

• absence of well-formed aortic arch arteries in the region of the aortic sac

disorganized myocardium ( J:93034 )

abnormal cardiac outflow tract development ( J:93034 )

• the outflow tract is disorganized, particularly around E9

• poorly formed outflow tract that ends in a blind sac

abnormal heart development ( J:93034 )

• at E8, the anterior heart field is defective based on marker analysis

abnormal heart looping ( J:93034 )

• hearts in 46% of mutants develop to looping stage I/II, 8% develop to looping stage III with looping always occurring to the right, and 46% arrest at looping stage 0

failure of heart looping ( J:69594 )

• heart looping fails to occur in the one embryo that is recovered at E10.5

abnormal heart ventricle morphology ( J:93034 )

• mutants have a common ventricle that is disorganized, particularly around E9

trabecula carnea hypoplasia ( J:93034 )

• poor trabeculation in the ventricular region

abnormal heart left ventricle morphology ( J:93034 )

• marker analysis indicates defects in patterning of the outer curvature of the left ventricle

absent heart right ventricle ( J:93034 )

• marker analysis indicates failure to form the right ventricle

abnormal pericardial cavity morphology ( J:69594 )

• pericardiac cavity is enlarged in the one embryo that is recovered at E10.5

pericardial edema ( J:93034 )

craniofacial

abnormal pharyngeal arch artery morphology ( J:93034 )

• absence of well-formed aortic arch arteries in the region of the aortic sac

nervous system

abnormal neural plate morphology ( J:69594 )

• neural plate is flat at E8.5

• anterior neural plate structures are present but are underdeveloped

holoprosencephaly ( J:69594 )

• the one recovered E10.5 embryo lacks normal structures anterior to the midbrain-hindbrain junction, resembling holoprosencephaly

homeostasis/metabolism

pericardial edema ( J:93034 )

muscle

trabecula carnea hypoplasia ( J:93034 )

• poor trabeculation in the ventricular region

disorganized myocardium ( J:93034 )