• mutants develop iris disease that is first noticeable at 6 months of age when eyes develop a pronounced peripupillary swelling accompanied by pronounced accumulation of clump cells on the iris surface

• develop a pigment dispersing iris disease

• the iris surface maintains an overall normal morphology during the fist year, after which it becomes increasingly atrophic

• develop a pigment dispersing iris disease

• pigment dispersion in the iris

• pigment dispersion in the iris

• pigment dispersion in the iris

• pigment dispersion in the iris

• triple mutants do not develop iris disease as seen in double Gpnmb^R150X and Tyrp1^bmice (J:128215)

• double mutants develop iris disease that is first noticeable by 6 months of age, when all eyes show slight swelling of peripupillary tissue

• at 12, 14, and 18 months of age, increasing degree of iris atrophy is observed, that includes full-thickness iris holes, profound transillumination, pigment dispersion and frequent pigment accumulation on the lens and cornea, and changes to the dimensions of the anterior chamber

• however, mutants do not develop glaucomatus nerve damage that is seen in DBA/2J mice

• severe pigment dispersing iris disease

• timing and severity of pigment dispersing iris disease is similar to that seen in either single mutant on a DBA/2J background

• atrophy is seen by 6-9 months of age

• double mutants are less susceptible to intraocular pressure elevation than DBA/2J mice

• severe pigment dispersing iris disease

• timing and severity of pigment dispersing iris disease is similar to that seen in either single mutant on a DBA/2J background

• loss of retinal ganglion cells

• atrophy

• atrophy

• atrophy

• loss of retinal ganglion cells

• loss of retinal ganglion cells

• atrophy

• atrophy

• atrophy

• loss of retinal ganglion cells