|
Allele Symbol Allele Name Allele ID |
Tg(Pdx1-cre)6Cvw transgene insertion 6, Christopher V E Wright MGI:2177604 |
||||||||||||||||||||||||||||
| Summary |
6 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die prior to P5
|
|
• the pancreas occupies 31% relative area compared to in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die within 2 days of birth
|
|
• the spaces between the remaining ductal epithelia are filled with stromal tissue, including fibroblasts and smooth musce cells
|
|
• very few beta cells are present between E17.5 and P1
|
|
• at E13.5, pancreatic precursor cells fail to expand resulting in fewer than normal glucagon+ and amylase+ cells
• pancreatic development is arrested at the early pancreatic cord stage
|
|
• the pancreas occupies 19% relative area compared to in wild-type mice
• the numbers of endocrine cells, exocrine cells, and total epithelial tissue is severely decreased compared to in wild-type mice with remaining cells exhibiting an almost exclusively ductal phenotype
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in mice lacking both alleles of Fox2a, pancreatic development is normal
|
| N |
• mice are euglycemic
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5
|
|
• at E18.5, the numbers of polypeptide producing cells are reduced compared to wild-type mice
|
|
• at E18.5, alpha cell mass is reduced 55% compared to in wild-type mice
|
|
• at E18.5, beta cell mass is reduced 57% compared to in wild-type mice
• however, beta cell differentiation is normal
|
|
• at E18.5, delta cell numbers are decreased compared to in wild-type mice
|
|
• mice exhibit islet hyperplasia
|
|
• the number of pancreatic endocrine progenitor cells is 2-fold less than in wild-type mice due to decreased cell proliferation of endocrine progenitor cells
• however, exocrine progenitor cells are normal in number and proliferation
|
|
• pancreatic glucagons is reduced 34.9% compared to in wild-type
|
|
• pancreatic insulin production is decreased 44% compared to in wild-type mice
|
| N |
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5
|
|
• pancreatic glucagons is reduced 34.9% compared to in wild-type
|
|
• pancreatic insulin production is decreased 44% compared to in wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| campomelic dysplasia | DOID:0050463 |
OMIM:114290 |
J:141017 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• glucose clearance is increased compared to in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• most mutant pups die after birth
|
|
• very few alpha cells are seen
|
|
• the number of insulin-expressing cells is decreased
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||
Analysis Tools