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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pdx1-cre)6Cvw
transgene insertion 6, Christopher V E Wright
MGI:2177604
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2+
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL MGI:3831161
cn2
Foxa1tm1Khk/Foxa1+
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL MGI:3831162
cn3
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL MGI:3831163
cn4
Sox9tm1Gsr/Sox9+
Tg(Pdx1-cre)6Cvw/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * FVB/N MGI:3817221
cn5
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Pdx1-cre)6Cvw/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784869
cn6
Pax6tm2Pgr/Pax6tm2Pgr
Tg(Pdx1-cre)6Cvw/0
involves: FVB * NMRI MGI:3045798


Genotype
MGI:3831161
cn1
Allelic
Composition
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2+
Tg(Pdx1-cre)6Cvw/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa1tm1Khk mutation (0 available); any Foxa1 mutation (5 available)
Foxa2tm1Khk mutation (1 available); any Foxa2 mutation (16 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• unlike in mice lacking both alleles of Fox2a, pancreatic development is normal

homeostasis/metabolism
N
• mice are euglycemic




Genotype
MGI:3831162
cn2
Allelic
Composition
Foxa1tm1Khk/Foxa1+
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa1tm1Khk mutation (0 available); any Foxa1 mutation (5 available)
Foxa2tm1Khk mutation (1 available); any Foxa2 mutation (16 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

endocrine/exocrine glands
• the pancreas occupies 31% relative area compared to in wild-type mice

digestive/alimentary system




Genotype
MGI:3831163
cn3
Allelic
Composition
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa1tm1Khk mutation (0 available); any Foxa1 mutation (5 available)
Foxa2tm1Khk mutation (1 available); any Foxa2 mutation (16 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 2 days of birth

endocrine/exocrine glands
• the spaces between the remaining ductal epithelia are filled with stromal tissue, including fibroblasts and smooth musce cells
• very few beta cells are present between E17.5 and P1
• at E13.5, pancreatic precursor cells fail to expand resulting in fewer than normal glucagon+ and amylase+ cells
• pancreatic development is arrested at the early pancreatic cord stage
• the pancreas occupies 19% relative area compared to in wild-type mice
• the numbers of endocrine cells, exocrine cells, and total epithelial tissue is severely decreased compared to in wild-type mice with remaining cells exhibiting an almost exclusively ductal phenotype

homeostasis/metabolism

digestive/alimentary system




Genotype
MGI:3817221
cn4
Allelic
Composition
Sox9tm1Gsr/Sox9+
Tg(Pdx1-cre)6Cvw/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm1Gsr mutation (2 available); any Sox9 mutation (14 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5
• at E18.5, the numbers of polypeptide producing cells are reduced compared to wild-type mice
• at E18.5, alpha cell mass is reduced 55% compared to in wild-type mice
• at E18.5, beta cell mass is reduced 57% compared to in wild-type mice
• however, beta cell differentiation is normal
• at E18.5, delta cell numbers are decreased compared to in wild-type mice
• mice exhibit islet hyperplasia
• the number of pancreatic endocrine progenitor cells is 2-fold less than in wild-type mice due to decreased cell proliferation of endocrine progenitor cells
• however, exocrine progenitor cells are normal in number and proliferation
• pancreatic glucagons is reduced 34.9% compared to in wild-type
• pancreatic insulin production is decreased 44% compared to in wild-type mice

digestive/alimentary system
N
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5

homeostasis/metabolism
• pancreatic glucagons is reduced 34.9% compared to in wild-type
• pancreatic insulin production is decreased 44% compared to in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Campomelic Dysplasia 114290 J:141017




Genotype
MGI:3784869
cn5
Allelic
Composition
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Pdx1-cre)6Cvw/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (336 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• glucose clearance is increased compared to in wild-type mice




Genotype
MGI:3045798
cn6
Allelic
Composition
Pax6tm2Pgr/Pax6tm2Pgr
Tg(Pdx1-cre)6Cvw/0
Genetic
Background
involves: FVB * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (58 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mutant pups die after birth

endocrine/exocrine glands
• very few alpha cells are seen
• the number of insulin-expressing cells is decreased





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory