Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Paw mutation
(0 available);
any
Ptpn11 mutation
(43 available)
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cellular
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• cultured trophoblast stem cells exhibit an increase in ploidy under differentiating conditions
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• null trophoblast stem cells die rapidly in culture
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• mutation causes decreased trophoblast stem cell proliferation and colony formation in culture
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Paw mutation
(0 available);
any
Ptpn11 mutation
(43 available)
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mortality/aging
growth/size/body
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• E8.5 embryos are small and appear similar in size to wild-type E7.5 embryos
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embryo
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• do not initiate the process of turning
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• about 30% fail to develop an A-P axis or any recognizable embryonic structures
• E8.5 embryos fail to elongate posteriorly
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• some E9.5 embryos develop a defined A-P axis, however all exhibit varying degrees of posterior truncations
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• 30% arrest development prior to the formation of recognizable structures
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• E8.5 embryos are small and appear similar in size to wild-type E7.5 embryos
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• development of axial mesodermal structures is severely affected
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• variable neural tube defects
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• disorganized neuroectoderm
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• headfolds do not fuse at the midline at E9
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• severely affected mutants have a kinked neural tube
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• E8.5 embryos do not develop a notochord
• abnormal notochord at E9.5; some have multiple, split, or kinked notochords
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• poorly developed somites, with some mutants able to form somites whereas others fail to make any recognizable somites
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• allantois does not develop properly and does not connect to the placenta
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• yolk sac is abnormally thin and wrinkled
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• yolk sac blood vessels fail to re-organize into a highly vascularized network at E9.5 and remain in a honeycombed pattern seen in E8.5 wild-type embryos, however vasculogenesis and production of the capillary plexus occurs normally
• thick-walled blood vessels do not form in yolk sacs
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cardiovascular system
nervous system
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• variable neural tube defects
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• disorganized neuroectoderm
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• headfolds do not fuse at the midline at E9
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• severely affected mutants have a kinked neural tube
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Allelic
Composition |
Egfrwa2/Egfrwa2
Ptpn11tm1Paw/Ptpn11+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation
(3 available);
any
Egfr mutation
(85 available)
Ptpn11tm1Paw mutation
(0 available);
any
Ptpn11 mutation
(43 available)
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Defects in the skin, lung and intestine of Egfrwa2/Egfrwa2 Ptpn11tm1Paw/+ mice
mortality/aging
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• only 30% survive to weaning, with most dying within 7-10 days after birth
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growth/size/body
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• exhibit progressive wasting
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muscle
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• lumen of stomach and small and large bowels are filled with desquamated epithelial cells, suggesting lack of peristalsis
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• decrease in the size of subcutaneous muscle tissue
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respiratory system
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• lungs are immaturely developed with poorly inflated areas
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• increase in thickness and cell masses of the alveolar septae
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• display breathing difficulties
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vision/eye
adipose tissue
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• decrease in the size of subcutaneous fat tissue
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digestive/alimentary system
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• the muscle layer of the bowel is poorly organized and is decreased in thickness
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• lumen of stomach and small and large bowels are filled with desquamated epithelial cells, suggesting lack of peristalsis
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integument
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• decrease in the size of subcutaneous fat tissue
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• poorly developed hair follicles
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• hair follicles are disordered
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• skin contains no or few disorganized hair follicles
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• hypotrophy in the epidermis
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• skin gradually becomes dry and flaky
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• skin gradually becomes dry and flaky
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Analysis Tools