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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ucp2tm1Lowl
targeted mutation 1, Bradford B Lowell
MGI:2176058
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ucp2tm1Lowl/Ucp2tm1Lowl B6.129S4-Ucp2tm1Lowl MGI:6285862
hm2
Ucp2tm1Lowl/Ucp2tm1Lowl involves: 129S4/SvJae * C57BL/6 MGI:3721510


Genotype
MGI:6285862
hm1
Allelic
Composition
Ucp2tm1Lowl/Ucp2tm1Lowl
Genetic
Background
B6.129S4-Ucp2tm1Lowl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp2tm1Lowl mutation (1 available); any Ucp2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• males exhibited moribund signs (and were thus sacrificed) between 4 and 34 months of age
• females became moribund between 6 and 29 months of age

growth/size/body
• 8 of 142 mice carried pancreatic cysts, never observed in wild-type controls
• mice gained less body weight as they aged
• 19 of 142 mice that carried liver cysts also had kidney cysts of variable number and size
• incidence of kidney cysts was significantly higher than that in wild-type controls
• no kidney cysts were detected between 3 and 10 months of age
• 63 of 142 dissected moribund mice (>12 months of age) exhibited liver cysts of variable number and size
• all mice carrying kidney cysts or pancreatic cysts had liver cysts except one mouse
• no liver cysts were detected between 3 and 10 months of age

liver/biliary system
• 63 of 142 dissected moribund mice (>12 months of age) exhibited liver cysts of variable number and size
• all mice carrying kidney cysts or pancreatic cysts had liver cysts except one mouse
• no liver cysts were detected between 3 and 10 months of age

renal/urinary system
• 19 of 142 mice that carried liver cysts also had kidney cysts of variable number and size
• incidence of kidney cysts was significantly higher than that in wild-type controls
• no kidney cysts were detected between 3 and 10 months of age

endocrine/exocrine glands
• 8 of 142 mice carried pancreatic cysts, never observed in wild-type controls

homeostasis/metabolism
N
• mice with polycystic livers showed no significant differences in plasma alanine transaminase (ALT) and aspartate transaminase (AST) levels relative to non-diseased mice or wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic liver disease DOID:0050770 OMIM:174050
J:272325




Genotype
MGI:3721510
hm2
Allelic
Composition
Ucp2tm1Lowl/Ucp2tm1Lowl
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucp2tm1Lowl mutation (1 available); any Ucp2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• MPTP treatment results in 62% loss of nigral dopaminergic neurons, approximately double the loss found in wild-type cells
• in situ measurement indicates an increase in reactive oxygen species production by nigral dopaminergic neurons as compared to control
• EM analysis of dopaminergic neurons indicates a decrease in mitochondrial number

nervous system
• MPTP treatment results in 62% loss of nigral dopaminergic neurons, approximately double the loss found in wild-type cells

homeostasis/metabolism
• MPTP treatment results in 62% loss of nigral dopaminergic neurons, approximately double the loss found in wild-type cells
• MPTP treatment results in significantly lower dopamine levels in the striatum as compared to control





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory