Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Gvr mutation
(0 available);
any
Cnga2 mutation
(15 available)
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mortality/aging
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• mice exhibit a high level of neonatal lethality
• however, litter size reduction within the first 24 hours after birth reduces neonatal lethality
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nervous system
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• long term potentiation induced by theta-burst stimulation is attenuated compared to in wild-type mice
• however, long term potentiation induced by high-frequency stimulation is normal
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• after theta burst stimulation, the field excitatory postsynaptic potential slope at the first pulse of the third theta-burst set is less than in wild-type mice
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Allelic Composition |
Cnga2tm1Gvr/Y
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Genetic Background |
involves: 129 * 129S1/SvImJ * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Gvr mutation
(0 available);
any
Cnga2 mutation
(15 available)
|
|
|
mortality/aging
|
• mice exhibit a high level of neonatal lethality
• however, litter size reduction within the first 24 hours after birth reduces neonatal lethality
|
nervous system
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• the external plexiform layer is reduced in thickness by 55% compared to in wild-type mice
• the septal receptor epithelium is 15% thinner than in wild-type mice
• mice exhibit smaller glomerular and granule cell layers and decreased olfactory bulb length compared with wild-type mice
• fibers in the olfactory bulb are more disorganized than in wild-type mice
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• mice exhibit narrower laminae than in wild-type mice with the biggest difference observed in the external plexiform layer
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• fewer olfactory receptor cells innervate the olfactory bulb compared to in wild-type mice
• fewer TH+ neurons are found in the olfactory bulb compared to in wild-type mice
• the olfactory bulb contains fewer mature and immature neurons compared to in wild-type mice
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Allelic Composition |
Cnga2tm1Gvr/Y
|
|
Genetic Background |
involves: 129 * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Gvr mutation
(0 available);
any
Cnga2 mutation
(15 available)
|
|
|
mortality/aging
|
• mice exhibit a high level of neonatal lethality
• however, litter size reduction within the first 24 hours after birth reduces neonatal lethality
|
nervous system
|
• long term potentiation induced by theta-burst stimulation is attenuated compared to in wild-type mice
• however, long term potentiation induced by high-frequency stimulation is normal
|
|
• after theta burst stimulation, the field excitatory postsynaptic potential slope at the first pulse of the third theta-burst set is less than in wild-type mice
|