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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Man2a1tm1Jxm
targeted mutation 1, Jamey Marth
MGI:2158937
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Man2a1tm1Jxm/Man2a1tm1Jxm involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3850627
cx2
Man2a1tm1Jxm/Man2a1tm1Jxm
Rag1tm1Mom/Rag1tm1Mom
B6.129-Rag1tm1Mom Man2a1tm1Jxm MGI:3850631
cx3
Man2a1tm1Jxm/Man2a1tm1Jxm
Man2a2tm1Mfu/Man2a2tm1Mfu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3850629


Genotype
MGI:3850627
hm1
Allelic
Composition
Man2a1tm1Jxm/Man2a1tm1Jxm
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1tm1Jxm mutation (1 available); any Man2a1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• small but significant increase in mortality by 18 months (J:74579)
• small but significant increase in mortality by 18 months (J:74579)

hematopoietic system
• mild to moderate (J:41621)
• mild to moderate (J:41621)
• variable red blood cell size (J:41621)
• variable red blood cell size (J:41621)
• increase as kidney disease develops (J:74579)
• increase as kidney disease develops (J:74579)
• high levels of reticulocytes in peripheral blood, up to 30% (J:41621)
• severity of reticulocytosis increases with age (J:41621)
• high levels of reticulocytes in peripheral blood, up to 30% (J:41621)
• severity of reticulocytosis increases with age (J:41621)
• increased numbers of erythroblasts in bone marrow (J:41621)
• increased numbers of erythroblasts in bone marrow (J:41621)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• marked splenomegaly at all ages examined (J:41621)
• marked splenomegaly at all ages examined (J:41621)
• reduced osmotic fragility (J:41621)
• reduced osmotic fragility (J:41621)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)

renal/urinary system
• an expanded mesangial matrix often causes obstruction of capillary lumina (J:74579)
• an expanded mesangial matrix often causes obstruction of capillary lumina (J:74579)
• extensive scarring of the kidneys develops (J:74579)
• extensive scarring of the kidneys develops (J:74579)
• normal to at least 3 months of age (J:74579)
• normal to at least 3 months of age (J:74579)
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• in about 60% of mice (J:74579)
• in about 60% of mice (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)

liver/biliary system
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)

respiratory system
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)

immune system
N
• B and T cell development and function normal (J:74579)
• B and T cell development and function normal (J:74579)
• increase as kidney disease develops (J:74579)
• increase as kidney disease develops (J:74579)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• marked splenomegaly at all ages examined (J:41621)
• marked splenomegaly at all ages examined (J:41621)
• circulating immune complexes become elevated (J:74579)
• circulating immune complexes become elevated (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• antinuclear antibody in about 60% of mice having hematuria (J:74579)
• antinuclear antibody in about 60% of mice having hematuria (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)

homeostasis/metabolism
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• in about 60% of mice (J:74579)
• in about 60% of mice (J:74579)




Genotype
MGI:3850631
cx2
Allelic
Composition
Man2a1tm1Jxm/Man2a1tm1Jxm
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background
B6.129-Rag1tm1Mom Man2a1tm1Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1tm1Jxm mutation (1 available); any Man2a1 mutation (11 available)
Rag1tm1Mom mutation (27 available); any Rag1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• severe weight loss (J:124348)
• severe weight loss (J:124348)

renal/urinary system
• increased mesangial cell apoptosis between 6 and 9 months of age (J:124348)
• increased mesangial cell apoptosis between 6 and 9 months of age (J:124348)
• increased proteinuria (J:124348)
• increased proteinuria (J:124348)
• exacerbated kidney disease (J:124348)
• increased macrophage infiltration of the kidney (J:124348)
• exacerbated kidney disease (J:124348)
• increased macrophage infiltration of the kidney (J:124348)
• nephron loss (J:124348)
• increased tissue sclerosis (J:124348)
• nephron loss (J:124348)
• increased tissue sclerosis (J:124348)

immune system
• exacerbated kidney disease (J:124348)
• increased macrophage infiltration of the kidney (J:124348)
• increased macrophage infiltration of the kidney (J:124348)
• exacerbated kidney disease (J:124348)

homeostasis/metabolism
• increased proteinuria (J:124348)
• increased proteinuria (J:124348)

integument

cellular
• increased mesangial cell apoptosis between 6 and 9 months of age (J:124348)
• increased mesangial cell apoptosis between 6 and 9 months of age (J:124348)




Genotype
MGI:3850629
cx3
Allelic
Composition
Man2a1tm1Jxm/Man2a1tm1Jxm
Man2a2tm1Mfu/Man2a2tm1Mfu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1tm1Jxm mutation (1 available); any Man2a1 mutation (11 available)
Man2a2tm1Mfu mutation (0 available); any Man2a2 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die shortly after birth (J:111055)
• most die shortly after birth (J:111055)
• very few survive to 3 weeks (J:111055)
• very few survive to 3 weeks (J:111055)
• some losses between E15 and E18 (J:111055)
• some losses between E15 and E18 (J:111055)

respiratory system
• reduced alveolar air space (J:111055)
• reduced alveolar air space (J:111055)
• thicker pulmonary epithelium layer (J:111055)
• thicker pulmonary epithelium layer (J:111055)
• newborns actively gasp for air (J:111055)
• fail to breath properly (J:111055)
• newborns actively gasp for air (J:111055)
• fail to breath properly (J:111055)

liver/biliary system
• frequently show liver damage (J:111055)
• E15 liver cells with abnormal vacuoles and enlarged mitochondria (J:111055)
• frequently show liver damage (J:111055)
• E15 liver cells with abnormal vacuoles and enlarged mitochondria (J:111055)

renal/urinary system
• E15 cells with abnormal vacuoles and enlarged mitochondria (J:111055)
• E15 cells with abnormal vacuoles and enlarged mitochondria (J:111055)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory