Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm3(APOE*4)Mae mutation
(3 available);
any
Apoe mutation
(145 available)
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behavior/neurological
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• low retention in water maze tests
• performance improves more with training than for Apoetm2(APOE*3)Mae mice
• performance in "delayed matching to place" does not improve
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• females are deficient in their ability to recognize spatial changes in object configuration in open field tests
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm3(APOE*4)Mae mutation
(3 available);
any
Apoe mutation
(145 available)
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growth/size/body
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• weight gain slows down after 4 weeks on high fat diets relative to Apoetm2(APOE*3)Mae
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homeostasis/metabolism
cardiovascular system
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• lesion size twice that in Apoetm2(APOE*3)Mae mice after 3 months on an atherogenic diet
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit neovascularization, ranging from mild neovascularization confined to an area adjacent to the RPE and Bruch's membrane to more extensive neovascularization that extends through the RPE and subretinal space and into the neural retina
• some aged miced fed a high-fat diet exhibit extensive neovascular lesions that involve the outer retinal vasculature
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adipose tissue
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• less epididymal fat than in Apoetm2(APOE*3)Mae mice
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immune system
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• in response to lipopolysaccharide injection, peaking after 3 hours
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• in response to lipopolysaccharide injection, peaking after 1 hour
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• higher level of HSV-1 shedding 6 days after ocular infection
• higher numbers of virus in the trigeminal nerve than in controls
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vision/eye
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit neovascularization, ranging from mild neovascularization confined to an area adjacent to the RPE and Bruch's membrane to more extensive neovascularization that extends through the RPE and subretinal space and into the neural retina
• some aged miced fed a high-fat diet exhibit extensive neovascular lesions that involve the outer retinal vasculature
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit severe retinal pigment epithelium (RPE) changes, including RPE hyperpigmentation, hypopigmentation and atrophy resulting in a thinner RPE cell layer, thick sub-RPE basal deposits and soft drusenoid deposits rich in neutral lipids
• RPE migration and proliferation are seen in areas of vascular invasion of the retina in aged mutants fed a high-fat diet
• aged mutants fed a high-fat diet exhibit disorganized or absent RPE basal infoldings and accumulation of deposits between the RPE and Bruch's membrane of varying thickness
• mutants that develop neovascularization show capillaries present on the RPE
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• atrophy of the retinal pigment epithelium is seen in aged mutants fed a high-fat diet
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• corneal hazing 9 days after ocular infection with HSV-1
• stromal opacity in 70% of mice by day 11
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit thinning of the outer nuclear layer
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit Bruch's membrane thickening
• mutants that develop neovascularization show regions of thinning or loss of Bruch's membrane and capillaries present on choroidal sides of Bruch's membrane
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nervous system
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit perivascular amyloid beta immunoreactivity in the eyes indicating amyloid beta deposits
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pigmentation
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• aged (65-127 weeks) mutants fed a high-fat diet exhibit severe retinal pigment epithelium (RPE) changes, including RPE hyperpigmentation, hypopigmentation and atrophy resulting in a thinner RPE cell layer, thick sub-RPE basal deposits and soft drusenoid deposits rich in neutral lipids
• RPE migration and proliferation are seen in areas of vascular invasion of the retina in aged mutants fed a high-fat diet
• aged mutants fed a high-fat diet exhibit disorganized or absent RPE basal infoldings and accumulation of deposits between the RPE and Bruch's membrane of varying thickness
• mutants that develop neovascularization show capillaries present on the RPE
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• atrophy of the retinal pigment epithelium is seen in aged mutants fed a high-fat diet
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homeostasis/metabolism
nervous system
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• significant plaque development on a high fat diet relative to Apoetm2(APOE*3)Mae mice who show very little plaque development
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm3(APOE*4)Mae mutation
(3 available);
any
Apoe mutation
(145 available)
Tg(Thy1-APPSwDutIowa)BWevn mutation
(2 available)
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nervous system
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• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
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• plaque deposition in cortical parenchyma increased 20%
• reduced deposition in cerebral microvasculature
• microglia are tightly associated with parenchymal plaque amyloid
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• increased number of neuroreactive astrocytes in cortex
• decreased number of neuroreactive astrocytes in thalamic region
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hematopoietic system
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• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
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immune system
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• increased number of neuroreactive microglia in cortex
• decreased number of neuroreactive microglia in thalamic region
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm3(APOE*4)Mae mutation
(3 available);
any
Apoe mutation
(145 available)
Tg(APPSWE)2576Kha mutation
(5 available)
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nervous system
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• increased levels of Amyloid beta 1-40 in cortical extracts at 3 months of age
• increased ratio of Amyloid beta 40:42 in cortical extracts at 3 months of age
• deposition delayed until after 12 months of age
• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels with very few parenchymal plaques at 15 months
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• Amyloid beta deposition starts around 12-15 months of age
• deposition is almost exclusively in cerebral blood vessels
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• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
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• decreased ratio of Amyloid beta 40:42 in cerebrospinal fluid at 3 months of age
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homeostasis/metabolism