Phenotypes associated with this allele
Allelic
Composition |
Smad1tm1Rjle/Smad1tm1Rjle
|
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Genetic
Background |
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Rjle mutation
(0 available);
any
Smad1 mutation
(32 available)
|
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mortality/aging
|
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• death at approximately E9.5
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embryo
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• defective allantois formation
|
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• allantois failed to fuse to chorion
|
Allelic
Composition |
Smad1tm1Rjle/Smad1+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Rjle mutation
(0 available);
any
Smad1 mutation
(32 available)
|
|
|
cardiovascular system
 N |
• mice do not exhibit increased right ventricular systolic pressure or right ventricular hypertrophy at 3 or 6 months of age
|
Allelic
Composition |
Smad1tm1Rjle/Smad1+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * NIH Black Swiss |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Rjle mutation
(0 available);
any
Smad1 mutation
(32 available)
|
|
|
mortality/aging
|
|
• significant reduction in the number of heterozygous mutant mice at weaning
|
nervous system
|
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• increased cellular proliferation in the dorsal region of the neural tube but not in the ventral region, resulting in neuroectodermal hypercellularity
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• about 22% of E11.5 embryos exhibit reductions in the midbrain and hindbrain
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• about 22% of E11.5 embryos exhibit reductions in the midbrain and hindbrain
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• have a curved cranial nerve likely to be a secondary effect caused by the abnormal architecture of the hindbrain
|
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• exhibit a truncated spinal accessory nerve at E11.5
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embryo
|
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• increased cellular proliferation in the dorsal region of the neural tube but not in the ventral region, resulting in neuroectodermal hypercellularity
|
Allelic
Composition |
Bmpr2tm1Mmue/Bmpr2+
Smad1tm1Rjle/Smad1+
|
|
Genetic
Background |
involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Mmue mutation
(0 available);
any
Bmpr2 mutation
(45 available)
Smad1tm1Rjle mutation
(0 available);
any
Smad1 mutation
(32 available)
|
|
|
cardiovascular system
|
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• right ventricular hypertrophy by 6 months of age
|
|
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• by 6 months of age, mice develop more severe elevations in right ventricular systolic pressure than single Bmpr2 heterozygotes
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growth/size/body
|
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• right ventricular hypertrophy by 6 months of age
|
muscle
|
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• right ventricular hypertrophy by 6 months of age
|
Analysis Tools