Analysis Tools
homeostasis/metabolism
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• 3-fold decrease in non-HDL cholesterol when fed high fat diet containing cholate for 12 weeks
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Allele Symbol Allele Name Allele ID |
Il1rntm1Dih targeted mutation 1, David Hirsh MGI:2157398 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 3-fold decrease in non-HDL cholesterol when fed high fat diet containing cholate for 12 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lower body weight apparent by 6 weeks of age
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• decreased serum levels of IL1 after endotoxin exposure
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• increased basal serum IL6 levels
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• increased basal serum amyloid P levels
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• increased hepatic acute phase protein response to subcutaneous turpentine administration, increased mortality to turpentine abscess induction: 50% of mice died by day 5
(J:61600)
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• more susceptible to lipopolysaccharide (LPS) endotoxin challenge
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• less susceptible to experimental Listeria monocytogenes infection
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• decreased number of offspring
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• 3-fold decrease in non-HDL cholesterol when fed high fat diet containing cholate for 12 weeks
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• decreased serum levels of IL1 after endotoxin exposure
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• increased basal serum IL6 levels
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• increased basal serum amyloid P levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygotes exhibit an intermediate phenotype when compared to wild-type and homozygous mice
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• more susceptible to lipopolysaccharide (LPS) endotoxin challenge
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• less susceptible to experimental Listeria monocytogenes infection, heterozygotes display an intermediate phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased death rate on a high cholesterol diet
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• significantly reduced plasma cholesterol levels relative to Apoetm1Unc homozygous controls on a normal diet
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• relative to singly homozyous Apoetm1Unc
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• massive infiltration of macrophage in the aortic arch
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| N |
• no intimal thickening occurs on a high cholesterol diet
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• elastic lamina in the media of the aortic root is destroyed
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• elastic lamina in the media of the coronary arteries is destroyed
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• massive infiltration of macrophage in the aortic arch
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• massive infiltration of macrophage in the aortic arch
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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