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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apoa4tm1Bres
targeted mutation 1, Jan L Breslow
MGI:2157162
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apoa4tm1Bres/Apoa4tm1Bres B6.129S4-Apoa4tm1Bres MGI:3698749
hm2
Apoa4tm1Bres/Apoa4tm1Bres either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6) MGI:3698746
cx3
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5051942


Genotype
MGI:3698749
hm1
Allelic
Composition
Apoa4tm1Bres/Apoa4tm1Bres
Genetic
Background
B6.129S4-Apoa4tm1Bres
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa4tm1Bres mutation (1 available); any Apoa4 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• increased severity of colitis experimentally induced by providing sodium dextran sulfate in the drinking water

immune system
• increased severity of colitis experimentally induced by providing sodium dextran sulfate in the drinking water




Genotype
MGI:3698746
hm2
Allelic
Composition
Apoa4tm1Bres/Apoa4tm1Bres
Genetic
Background
either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa4tm1Bres mutation (1 available); any Apoa4 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• decreased triglyceride transport rate
• reduced 45%
• levels are tied more to Apoa3 levels (which are also reduced) than to Apoa4 levels
• 27% increase in the HDL-cholesterol ester catabolic rate
• reduced 23% in both fed and fasted state

behavior/neurological
• animals fasted 18 hours before being given unlimited food had higher short term food intake than controls but the difference is only significant on a predominantly 129 background




Genotype
MGI:5051942
cx3
Allelic
Composition
Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa4tm1Bres mutation (1 available); any Apoa4 mutation (7 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival compared to wild-type mice and transgenic mice wild-type for Apoa4

nervous system
• accelerated deposition compared to transgenic mice wild-type for Apoa4
• large pyramidal neurons in cortical layer 5 and neurons in hippocampus contain more disrupted morphologies indicating enhanced neuron loss compared to transgenic mice wild-type for Apoa4
• loss of neurons is increased in areas of the cortex and CA1, CA3 of the hippocampus

behavior/neurological
• impaired spatial learning (slower decrease in escape latency during training in a morris water maze) compared to transgenic mice wild-type for Apoa4
• more time spent in the incorrect quadrant in a probe trial in a morris water maze compared to transgenic mice wild-type for Apoa4

homeostasis/metabolism
• accelerated deposition compared to transgenic mice wild-type for Apoa4

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:169682





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory