Mouse Genome Informatics
hm1
    Apoa4tm1Bres/Apoa4tm1Bres
B6.129S4-Apoa4tm1Bres
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
digestive/alimentary system
• increased severity of colitis experimentally induced by providing sodium dextran sulfate in the drinking water

immune system
• increased severity of colitis experimentally induced by providing sodium dextran sulfate in the drinking water


Mouse Genome Informatics
hm2
    Apoa4tm1Bres/Apoa4tm1Bres
either: 129S4/SvJae or (involves: 129S4/SvJae * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• decreased triglyceride transport rate
• reduced 45%
• levels are tied more to Apoa3 levels (which are also reduced) than to Apoa4 levels
• 27% increase in the HDL-cholesterol ester catabolic rate
• reduced 23% in both fed and fasted state

behavior/neurological
• animals fasted 18 hours before being given unlimited food had higher short term food intake than controls but the difference is only significant on a predominantly 129 background


Mouse Genome Informatics
cx3
    Apoa4tm1Bres/Apoa4tm1Bres
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?

involves: 129S4/SvJae * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• impaired survival compared to wild-type mice and transgenic mice wild-type for Apoa4

nervous system
• accelerated deposition compared to transgenic mice wild-type for Apoa4
• large pyramidal neurons in cortical layer 5 and neurons in hippocampus contain more disrupted morphologies indicating enhanced neuron loss compared to transgenic mice wild-type for Apoa4
• loss of neurons is increased in areas of the cortex and CA1, CA3 of the hippocampus

behavior/neurological
• impaired spatial learning (slower decrease in escape latency during training in a morris water maze) compared to transgenic mice wild-type for Apoa4
• more time spent in the incorrect quadrant in a probe trial in a morris water maze compared to transgenic mice wild-type for Apoa4

homeostasis/metabolism
• accelerated deposition compared to transgenic mice wild-type for Apoa4

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:169682