Mouse Genome Informatics
hm1
    Hk1dea/Hk1dea
A/J-Hk1dea/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size/body

hematopoietic system
• accelerated erythropoiesis
• spherocytes are absent and echinocytes are invariably present in peripheral blood smears
• red cells pull apart and only thin strands of membrane attach the two halves in blood smears
• decreased red cell mean corpuscular hemoglobin content
• have 83% circulating reticulocytes compared to 3.1% in controls
• the normal nodular splenic architecture is completely effaced
• expansion of the splenic red pulp
• spleen weight is increased fourfold

homeostasis/metabolism
• elevated bilirubin levels, indicating red cell hemolysis
• iron accumulation in kidney tubules and liver but not in the spleen
• iron accumulation in kidney tubules and liver but not in the spleen

reproductive system

immune system
• the normal nodular splenic architecture is completely effaced
• expansion of the splenic red pulp
• spleen weight is increased fourfold

liver/biliary system
• iron accumulation in kidney tubules and liver but not in the spleen

renal/urinary system
• iron accumulation in kidney tubules and liver but not in the spleen

integument
• extreme pallor at birth that persists throughout life