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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Utrntm1Ked
targeted mutation 1, Kay E Davies
MGI:2148589
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Utrntm1Ked/Utrntm1Ked involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA MGI:2176875
cx2
Dmdmdx-3Cv/Dmdmdx-3Cv
Utrntm1Ked/Utrntm1Ked
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus MGI:3798662
cx3
Dmdmdx-3Cv/Y
Utrntm1Ked/Utrntm1Ked
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus MGI:3798665
cx4
Dmdmdx/Dmdmdx
Utrntm1Ked/Utrntm1Ked
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA MGI:2176879


Genotype
MGI:2176875
hm1
Allelic
Composition
Utrntm1Ked/Utrntm1Ked
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Utrntm1Ked mutation (12 available); any Utrn mutation (224 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decrease in junctional folding at the postsynaptic membrane
• reduction in number of acetylcholine receptors in each junction
• the amplitude of miniature endplate currents is reduced by 20% in the extensor digitorum longus muscle, however other features of neuromuscular transmission are normal

muscle
N
• no indication of muscle weakness or degeneration of cardiac or skeletal muscle

renal/urinary system
N
• normal kidney and function

respiratory system
N
• no signs of abnormal breathing and the lung appears normal




Genotype
MGI:3798662
cx2
Allelic
Composition
Dmdmdx-3Cv/Dmdmdx-3Cv
Utrntm1Ked/Utrntm1Ked
Genetic
Background
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (2 available); any Dmd mutation (159 available)
Utrntm1Ked mutation (12 available); any Utrn mutation (224 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• authors state that mice develop the same skeletal muscle abnormalities as observed in Dmdmdx Utrntm1Ked mice

nervous system
N
• unlike in Dmdmdx Utrntm1Ked mice, brain morphology is normal

respiratory system
N
• unlike in Dmdmdx Utrntm1Ked mice, lung morphology is normal

liver/biliary system
N
• liver morphology is normal

renal/urinary system
N
• kidney morphology is normal

reproductive system
N
• ovary morphology is normal




Genotype
MGI:3798665
cx3
Allelic
Composition
Dmdmdx-3Cv/Y
Utrntm1Ked/Utrntm1Ked
Genetic
Background
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (2 available); any Dmd mutation (159 available)
Utrntm1Ked mutation (12 available); any Utrn mutation (224 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• authors state that mice develop the same skeletal muscle abnormalities as observed in Dmdmdx Utrntm1Ked mice

nervous system
N
• unlike in Dmdmdx Utrntm1Ked mice, brain morphology is normal

respiratory system
N
• unlike in Dmdmdx Utrntm1Ked mice, lung morphology is normal

liver/biliary system
N
• liver morphology is normal

renal/urinary system
N
• kidney morphology is normal

reproductive system
N
• testis morphology is normal




Genotype
MGI:2176879
cx4
Allelic
Composition
Dmdmdx/Dmdmdx
Utrntm1Ked/Utrntm1Ked
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (42 available); any Dmd mutation (159 available)
Utrntm1Ked mutation (12 available); any Utrn mutation (224 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all succumb to premature death by 20 weeks of age

behavior/neurological
• slack posture by 4 to 6 weeks of age
• decrease in mobility and abnormal field behavior by 4 to 6 weeks of age
• waddling gait

growth/size/body

muscle
• muscle fibers are irregularly shaped and sized, many with centralized nuclei and some lymphocyte infiltration
• some fibers contain fat or appear to be replaced by adipose cells
• muscular dystrophy begins at 6 days of age and becomes severe by 10 weeks of age, earlier than in single Dmd mutants

respiratory system
• exhibit abnormal breathing by 4 to 6 weeks of age

skeleton

nervous system
• postsynaptic endplate regions exhibit a virtual absence of junctional folding at the postsynaptic membrane
• about 40% decrease in acetylcholine receptors at the synapse

limbs/digits/tail
• abnormally postured hindlimbs with joint contractures

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:42388





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory