Phenotypes associated with this allele

• Allele Symbol: Map7^{Gt(ROSABetageo)1Sor}
• Allele Name: gene trap 1, Philippe Soriano
• Allele ID: MGI:2148221
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map7^Gt(ROSABetageo)1Sor/Map7^Gt(ROSABetageo)1Sor	either: 129S4/SvJaeSor-Map7^Gt(ROSABetageo)1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)	MGI:2175122
hm2	Map7^Gt(ROSABetageo)1Sor/Map7^Gt(ROSABetageo)1Sor	involves: 129S4/SvJaeSor * C57BL/6J	MGI:5608896
ht3	Map7^Gt(ROSABetageo)1Sor/Map7^mshi	involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J	MGI:5608793

Genotype
MGI:2175122

hm1

• Allelic Composition: Map7^{Gt(ROSABetageo)1Sor}/Map7^{Gt(ROSABetageo)1Sor}
• Genetic Background: either: 129S4/SvJaeSor-Map7^{Gt(ROSABetageo)1Sor} or (involves: 129S4/SvJaeSor * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:62570 )

♂ • aberrant microtubule morphology

small seminiferous tubules ( J:62570 )

♂

increased Leydig cell number ( J:62570 )

♂

small testis ( J:62570 )

♂ • approximately 1/3 the size of littermates

reproductive system

abnormal spermatid morphology ( J:62570 )

♂ • abnormal spermatids exhibiting aberrant microtubule morphology

decreased germ cell number ( J:62570 )

• progressive loss of germ cells of all stages

abnormal Sertoli cell morphology ( J:62570 )

♂ • aberrant microtubule morphology

small seminiferous tubules ( J:62570 )

♂

increased Leydig cell number ( J:62570 )

♂

small testis ( J:62570 )

♂ • approximately 1/3 the size of littermates

abnormal spermiogenesis ( J:62570 )

♂ • abnormal formation of elongating spermatids

small epididymis ( J:62570 )

♂ • reduced size

♂ • vas deferens, prostate, and seminal vesicle were of normal size and morphology

male infertility ( J:62570 )

♂

cellular

abnormal spermatid morphology ( J:62570 )

♂ • abnormal spermatids exhibiting aberrant microtubule morphology

decreased germ cell number ( J:62570 )

• progressive loss of germ cells of all stages

Genotype
MGI:5608896

hm2

• Allelic Composition: Map7^{Gt(ROSABetageo)1Sor}/Map7^{Gt(ROSABetageo)1Sor}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

reproductive system

abnormal seminiferous tubule morphology ( J:148349 )

♂ • at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia

♂ • tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is extracellular vacuolization, which is more severe in these homozygotes than in mshi homozygotes or compound heterozygotes, indicative of more advanced tubule degeneration

small seminiferous tubules ( J:148349 )

♂

small testis ( J:148349 )

♂

decreased testis weight ( J:148349 )

♂ • homozygotes have much smaller testes, on average 70mg where heterozygous controls have an average testes weight of 250mg

male infertility ( J:148349 )

♂ • although males copulate and cause vaginal plugs, they fail to impregnate females

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:148349 )

♂ • at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia

♂ • tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is extracellular vacuolization, which is more severe in these homozygotes than in mshi homozygotes or compound heterozygotes, indicative of more advanced tubule degeneration

small seminiferous tubules ( J:148349 )

♂

small testis ( J:148349 )

♂

decreased testis weight ( J:148349 )

♂ • homozygotes have much smaller testes, on average 70mg where heterozygous controls have an average testes weight of 250mg

Genotype
MGI:5608793

ht3

• Allelic Composition: Map7^{Gt(ROSABetageo)1Sor}/Map7^mshi
• Genetic Background: involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:148349 )

♂ • at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia

♂ • tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele

small seminiferous tubules ( J:148349 )

♂

small testis ( J:148349 )

♂

decreased testis weight ( J:148349 )

♂ • compound heterozygotes have a testes weight decreased to a similar degree as individual homozygotes for each allele, with the average weight less than 75mg compared with a heterozygous weight of 225 mg

reproductive system

decreased male germ cell number ( J:148349 )

♂

abnormal seminiferous tubule morphology ( J:148349 )

♂ • at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia

♂ • tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele

small seminiferous tubules ( J:148349 )

♂

small testis ( J:148349 )

♂

decreased testis weight ( J:148349 )

♂ • compound heterozygotes have a testes weight decreased to a similar degree as individual homozygotes for each allele, with the average weight less than 75mg compared with a heterozygous weight of 225 mg

male infertility ( J:148349 )

♂

cellular

decreased male germ cell number ( J:148349 )

♂