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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map7Gt(ROSABetageo)1Sor
gene trap 1, Philippe Soriano
MGI:2148221
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map7Gt(ROSABetageo)1Sor/Map7Gt(ROSABetageo)1Sor either: 129S4/SvJaeSor-Map7Gt(ROSABetageo)1Sor or (involves: 129S4/SvJaeSor * C57BL/6J) MGI:2175122
hm2
Map7Gt(ROSABetageo)1Sor/Map7Gt(ROSABetageo)1Sor involves: 129S4/SvJaeSor * C57BL/6J MGI:5608896
ht3
Map7Gt(ROSABetageo)1Sor/Map7mshi involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J MGI:5608793


Genotype
MGI:2175122
hm1
Allelic
Composition
Map7Gt(ROSABetageo)1Sor/Map7Gt(ROSABetageo)1Sor
Genetic
Background
either: 129S4/SvJaeSor-Map7Gt(ROSABetageo)1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map7Gt(ROSABetageo)1Sor mutation (1 available); any Map7 mutation (230 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• abnormal spermatids exhibiting aberrant microtubule morphology
• progressive loss of germ cells of all stages

endocrine/exocrine glands
• aberrant microtubule morphology
• approximately 1/3 the size of littermates

reproductive system
• abnormal spermatids exhibiting aberrant microtubule morphology
• progressive loss of germ cells of all stages
• aberrant microtubule morphology
• approximately 1/3 the size of littermates
• abnormal formation of elongating spermatids
• reduced size
• vas deferens, prostate, and seminal vesicle were of normal size and morphology




Genotype
MGI:5608896
hm2
Allelic
Composition
Map7Gt(ROSABetageo)1Sor/Map7Gt(ROSABetageo)1Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map7Gt(ROSABetageo)1Sor mutation (1 available); any Map7 mutation (230 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is extracellular vacuolization, which is more severe in these homozygotes than in mshi homozygotes or compound heterozygotes, indicative of more advanced tubule degeneration
• homozygotes have much smaller testes, on average 70mg where heterozygous controls have an average testes weight of 250mg
• although males copulate and cause vaginal plugs, they fail to impregnate females

endocrine/exocrine glands
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is extracellular vacuolization, which is more severe in these homozygotes than in mshi homozygotes or compound heterozygotes, indicative of more advanced tubule degeneration
• homozygotes have much smaller testes, on average 70mg where heterozygous controls have an average testes weight of 250mg




Genotype
MGI:5608793
ht3
Allelic
Composition
Map7Gt(ROSABetageo)1Sor/Map7mshi
Genetic
Background
involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map7Gt(ROSABetageo)1Sor mutation (1 available); any Map7 mutation (230 available)
Map7mshi mutation (1 available); any Map7 mutation (230 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

endocrine/exocrine glands
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
• compound heterozygotes have a testes weight decreased to a similar degree as individual homozygotes for each allele, with the average weight less than 75mg compared with a heterozygous weight of 225 mg

reproductive system
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
• compound heterozygotes have a testes weight decreased to a similar degree as individual homozygotes for each allele, with the average weight less than 75mg compared with a heterozygous weight of 225 mg





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory