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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abca1tm1Jdm
targeted mutation 1, John D McNeish
MGI:1935192
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abca1tm1Jdm/Abca1tm1Jdm DBA/1-Abca1tm1Jdm/J MGI:3796570
hm2
Abca1tm1Jdm/Abca1tm1Jdm DBA/1LacJ-Abca1tm1Jdm MGI:2450723
hm3
Abca1tm1Jdm/Abca1tm1Jdm involves: C57BL/6 * DBA/1LacJ MGI:3803112
hm4
Abca1tm1Jdm/Abca1tm1Jdm involves: DBA/1LacJ MGI:2687004
ht5
Abca1tm1Jdm/Abca1+ DBA/1LacJ-Abca1tm1Jdm MGI:2450724
cx6
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ MGI:5451013
cx7
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Tg(APOA1)1Rub/0
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ MGI:5451014
cx8
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Apoetm1Unc/Apoetm1Unc
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ MGI:5451015
cx9
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ MGI:3796569
cx10
Abca1tm1Jdm/Abca1tm1Jdm
Tgm2tm1Gml/Tgm2tm1Gml
involves: C57BL/6 * DBA/1LacJ MGI:3803113
cx11
Abca1tm1Jdm/Abca1tm1Jdm
Tg(Thy1-APP)3Somm/0
involves: C57BL/6J * DBA/1LacJ * DBA/2 MGI:4833954


Genotype
MGI:3796570
hm1
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Genetic
Background
DBA/1-Abca1tm1Jdm/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

homeostasis/metabolism




Genotype
MGI:2450723
hm2
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Genetic
Background
DBA/1LacJ-Abca1tm1Jdm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pulmonary lesions in Abca1tm1Jdm/Abca1tm1Jdm mice

mortality/aging
• incomplete penetrance
• at weaning, numbers of homozygotes recovered is reduced by about 50% from expected suggesting significant perinatal/postnatal lethality
• numbers of homozygous offspring recovered at weaning is significantly reduced from expected

cardiovascular system
• perivisceral

digestive/alimentary system
• more cholesterol absorbed, relative to wild-type, on both chow and Western diets

embryogenesis

endocrine/exocrine glands

growth/size/body

hematopoietic system
• of apoptotic cells

homeostasis/metabolism
• low apolipoprotein A-I level, 99.8% reduction relative to wild-type on chow diet and undetectable on Western-type diet
• low apolipoprotein B level, 70% reduction relative to wild-type on chow diet
• more cholesterol absorbed, relative to wild-type, on both chow and Western diets
• ~70% reduction to wild-type on chow diet (J:61679)
• reduced relative to wild-type on Western-type diet (J:61679)
• 99.5% reduction relative to wild-type on chow diet (J:61679)
• undetectable on Western-type diet (J:61679)
• 70% reduction relative to wild-type on chow diet
• decreased levels of fat-soluble vitamins in plasma

immune system
• of apoptotic cells

reproductive system
• due to abnormal placental development

respiratory system
• macroscopic and microscopic pale foci in 5-10% of parenchyma in mice 7 months or older, increasingly prevalent with age
• foci consisted of type II pneumocytes, lipid-laden macrophages, and cholesterol clefts
• abnormal architecture; alveolar septae are focally expanded by mild type II pneumocyte hypertrophy, macrophages, and aggregates of lymphocytes and plasma cells
• lipid accumulation within alveolar cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Tangier Disease; TGD 205400 J:61679




Genotype
MGI:3803112
hm3
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Genetic
Background
involves: C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• numbers of homozygous offspring recovered at weaning is significantly reduced from expected

hematopoietic system
• massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice
• isolated peritoneal macrophages exposed to apoptotic thymocytes internalize similar numbers of cells (1-2 cells) as wild-type after 15-30 minutes, but this number does not increase with time as with wild-type which internalize 4-5 cells at 60-120 minutes
• after massive thymic involution induced by dexamethasone treatment, macrophages display reduced phagocytosis ability compared to wild-type, and similar to single-null mice

immune system
• massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice
• isolated peritoneal macrophages exposed to apoptotic thymocytes internalize similar numbers of cells (1-2 cells) as wild-type after 15-30 minutes, but this number does not increase with time as with wild-type which internalize 4-5 cells at 60-120 minutes
• after massive thymic involution induced by dexamethasone treatment, macrophages display reduced phagocytosis ability compared to wild-type, and similar to single-null mice

homeostasis/metabolism
N
• circulating triglyceride levels are normal in fasting mice
• levels are reduced compared to adult wild-type or Tgm2-null mice
• adult mice show nearly complete loss of HDL cholesterol in fasting mice

endocrine/exocrine glands
• massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice




Genotype
MGI:2687004
hm4
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Genetic
Background
involves: DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• strong reduction of plasma beta-sitosterol and campesterol levels




Genotype
MGI:2450724
ht5
Allelic
Composition
Abca1tm1Jdm/Abca1+
Genetic
Background
DBA/1LacJ-Abca1tm1Jdm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• low apolipoprotein A-I level, reduced relative to wild-type on chow and Western-type diets
• low apolipoprotein B level, 20% reduction on chow diet
• reduced relative to wild-type on chow and Western-type diets
• 20% reduction on chow diet

respiratory system
• microscopic, but not macroscopic, pale foci observed
• foci consisted of type II pneumocytes, lipid-laden macrophages, and cholesterol clefts




Genotype
MGI:5451013
cx6
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit a decrease in heterogeneous distribution of bone tissue material properties compared with wild-type mice
• from in vitro bone marrow cultures treated with G-CSF or IL3
• from in vitro bone marrow cultures treated with G-CSF
• from in vitro bone marrow cultures treated with IL3
• hematopoietic stem and multipotential progenitor cell (HSPC) mobilization is enhanced that is bone marrow- and G-CSF-dependent driven by increased IL23/IL17

skeleton

immune system
• from in vitro bone marrow cultures treated with G-CSF or IL3
• from in vitro bone marrow cultures treated with G-CSF
• from in vitro bone marrow cultures treated with IL3




Genotype
MGI:5451014
cx7
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Tg(APOA1)1Rub/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (24 available)
Tg(APOA1)1Rub mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in bone marrow transplants experiments, hematopoietic stem and multipotential progenitor cell (HSPC) exhibit reduced mobilization compared with Abca1tm1Jdm Abcg1tm1Dgen double homozygotes




Genotype
MGI:5451015
cx8
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Apoetm1Unc/Apoetm1Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (24 available)
Apoetm1Unc mutation (22 available); any Apoe mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice fed a high fat diet exhibit increased hematopoietic stem and multipotential progenitor cell (HSPC) mobilization compared with wild-type mice
• however, treatment with recombinant HDL suppresses this increase




Genotype
MGI:3796569
cx9
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Abcg1tm1Dgen/Abcg1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
Abcg1tm1Dgen mutation (0 available); any Abcg1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit increased secretion of TNF-alpha, IL-6, IL-1beta, and IL-12 compared to wild-type mice
• mice exhibit increased secretion of MIP-1alpha, MIP-2, growth-regulated oncogene alpha and MCP-1 compared to wild-type mice

cellular

homeostasis/metabolism




Genotype
MGI:3803113
cx10
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Tgm2tm1Gml/Tgm2tm1Gml
Genetic
Background
involves: C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
Tgm2tm1Gml mutation (3 available); any Tgm2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
• massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice
• isolated peritoneal macrophages exposed to apoptotic thymocytes internalize similar numbers of cells (1-2 cells) as wild-type after 15-30 minutes, but this number does not increase with time as with wild-type which internalize 4-5 cells at 60-120 minutes
• after massive thymic involution induced by dexamethasone treatment, macrophages display reduced phagocytosis ability compared to wild-type, and similar to single-null mice

immune system
• massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice
• isolated peritoneal macrophages exposed to apoptotic thymocytes internalize similar numbers of cells (1-2 cells) as wild-type after 15-30 minutes, but this number does not increase with time as with wild-type which internalize 4-5 cells at 60-120 minutes
• after massive thymic involution induced by dexamethasone treatment, macrophages display reduced phagocytosis ability compared to wild-type, and similar to single-null mice

homeostasis/metabolism
N
• circulating triglyceride levels are normal in fasting mice
• levels are reduced compared to adult wild-type or Tgm2-null mice
• adult mice show nearly complete loss of HDL cholesterol in fasting mice

endocrine/exocrine glands
• massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice




Genotype
MGI:4833954
cx11
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Tg(Thy1-APP)3Somm/0
Genetic
Background
involves: C57BL/6J * DBA/1LacJ * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
Tg(Thy1-APP)3Somm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

nervous system
• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice
• at 13 months, mice exhibit more cerebral amyloid angiopathy than in Tg(Thy1-APP)3Somm mice

cardiovascular system
• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice

homeostasis/metabolism
• mice exhibit a 2-fold increase in insoluble beta-amyloid in the brain compared with Tg(Thy1-APP)3Somm mice
• at 13 months, mice exhibit more cerebral amyloid angiopathy than in Tg(Thy1-APP)3Somm mice





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory