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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
C5ar1tm1Cge
targeted mutation 1, Craig Gerard
MGI:1934246
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
C5ar1tm1Cge/C5ar1tm1Cge B6.129S4(Cg)-C5ar1tm1Cge MGI:6382542
hm2
C5ar1tm1Cge/C5ar1tm1Cge involves: 129S4/SvJae MGI:2662371
hm3
C5ar1tm1Cge/C5ar1tm1Cge involves: 129S4/SvJae * C57BL/6 MGI:5295998
cx4
C3ar1tm1Cge/C3ar1tm1Cge
C5ar1tm1Cge/C5ar1tm1Cge
B6.Cg-C3ar1tm1Cge C5ar1tm1Cge MGI:6382540


Genotype
MGI:6382542
hm1
Allelic
Composition
C5ar1tm1Cge/C5ar1tm1Cge
Genetic
Background
B6.129S4(Cg)-C5ar1tm1Cge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Cge mutation (3 available); any C5ar1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the amplitude of the c-wave is reduced at 12 months of age, but not at 8 weeks of age
• however, no other component of the dc-ERG is different and mice show normal ERG a-waves and b-waves even at 12 months of age

homeostasis/metabolism
• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age




Genotype
MGI:2662371
hm2
Allelic
Composition
C5ar1tm1Cge/C5ar1tm1Cge
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Cge mutation (3 available); any C5ar1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants challenged with Psuedomonas aeruginosa succumb in the second day after challenge while no wild-type mice die

immune system
• when peritoneal inflammation is induced with glycogen in mutants, a decreased number of neutrophils is elicited
• after injection of chicken egg albumin in the tail and administration of antibodies to egg albumin intratracheally, the null mice exhibit almost complete protection from inflammatory response upon examination of lung tissue
• mutants are unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite an increase in neutrophil influx, and succumb to pneumonia
• however, mutants are able to clear the bacteria when challenged intraperitoneally
• mutants challenged with a sublethal dose of Pseudomonas become superinfected with secondary bacterial strains

hematopoietic system
• when peritoneal inflammation is induced with glycogen in mutants, a decreased number of neutrophils is elicited




Genotype
MGI:5295998
hm3
Allelic
Composition
C5ar1tm1Cge/C5ar1tm1Cge
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Cge mutation (3 available); any C5ar1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

immune system
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
• Il-6 production after vitamin D3 stimulation is significantly reduced

hematopoietic system
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

homeostasis/metabolism
• Il-6 production after vitamin D3 stimulation is significantly reduced




Genotype
MGI:6382540
cx4
Allelic
Composition
C3ar1tm1Cge/C3ar1tm1Cge
C5ar1tm1Cge/C5ar1tm1Cge
Genetic
Background
B6.Cg-C3ar1tm1Cge C5ar1tm1Cge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3ar1tm1Cge mutation (2 available); any C3ar1 mutation (23 available)
C5ar1tm1Cge mutation (3 available); any C5ar1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice
• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
• density of horizontal cells is decreased
• the normal structure of the outer segment discs is lost at 6 months of age
• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months
• the inner nuclear layer is thinner at 3 and 14 months of age
• outer nuclear layer thinning is seen at older ages
• the outer nuclear layer is disorganized at 3 months of age
• mice show progressive retinal cell loss
• the fast oscillation is reduced at 6 months of age
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show a more severe reduction in ERG amplitude, however this phenotype is not related to immune responses as IL17-producting cells are diminished
• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age
• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age
• the amplitude of the c-wave is reduced at 6 months of age

homeostasis/metabolism
• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age
• plasma lysophosphatidylcholine levels are decreased at 3 and 14 months of age

cellular
• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months
• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice

nervous system
• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age
• density of horizontal cells is decreased
• the normal structure of the outer segment discs is lost at 6 months of age

pigmentation
• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory