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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trpv1tm1Jul
targeted mutation 1, David Julius
MGI:1934023
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trpv1tm1Jul/Trpv1tm1Jul B6.129X1-Trpv1tm1Jul MGI:4418196
hm2
Trpv1tm1Jul/Trpv1tm1Jul B6.129X1-Trpv1tm1Jul/J MGI:4417977
hm3
Trpv1tm1Jul/Trpv1tm1Jul involves: 129X1/SvJ MGI:2655322
hm4
Trpv1tm1Jul/Trpv1tm1Jul involves: 129X1/SvJ * C57BL/6 MGI:3834761
cn5
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+
Trpv1tm1Jul/Trpv1tm1Jul
Tg(Mrgpra3-GFP/cre)#Xzd/0
involves: 129P2/OlaHsd * 129X1/SvJ MGI:5506549
cx6
Trpv1tm1Jul/Trpv1tm1Jul
Pirttm2Xzd/Pirt+
involves: 129X1/SvJ MGI:5697887


Genotype
MGI:4418196
hm1
Allelic
Composition
Trpv1tm1Jul/Trpv1tm1Jul
Genetic
Background
B6.129X1-Trpv1tm1Jul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation (1 available); any Trpv1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal general locomotion and pain threshold
• mice exhibit less freezing after stress sensitization compared with wild-type mice
• mice exhibit less conditioned freezing in response to a context compared with wild-type mice
• mice exhibit less conditioned freezing in response to an auditory cue compared with wild-type mice
• in a light-dark test, mice spend more time exploring the light compartment than wild-type mice
• in an elevated plus maze, mice spend more time in open arms and make more entries into open arms compared with wild-type mice

renal/urinary system
• DOCA-salt-treated mice exhibit a greater increase in urinary 8-isoprostane and albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary 8-isoprotane and albumin excretion
• DOCA-salt-treated mice exhibit a greater increase in urinary albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary albumin excretion
• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice
• however, DEXA treatment prevents kidney inflammation
• DOCA-salt-treated mice exhibit a greater glomerulosclerosis than similarly treated wild-type mice
• however, DEXA treatment reduces glomerulosclerosis
• DOCA-salt-treated mice exhibit more severe renal tubular injury in the renal cortex and outer medulla than similarly treated wild-type mice
• however, DEXA treatment reduces renal tubule damage

nervous system
N
• mice exhibit normal paired-pulse facilitation, auditory brainstem responses, and distortion-product otoacoustic emissions
• following high frequency stimulation, long term potentiation is weaker than in similarly treated wild-type mice

homeostasis/metabolism
• DOCA-salt-treated mice exhibit a greater increase in urinary 8-isoprostane and albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary 8-isoprotane and albumin excretion
• DOCA-salt-treated mice exhibit a greater increase in urinary albumin excretion compared with similarly treated wild-type mice
• however, DEXA treatment decreased urinary albumin excretion
• DOCA-salt-treated mice exhibit increased renal damage compared with similarly treated wild-type mice
• however, DEXA treatment ameliorates renal damage

immune system
• DOCA-salt-treated mice exhibit increased MCP-1 protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
• DOCA-salt-treated mice exhibit increased IL6 protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
• DOCA-salt-treated mice exhibit increased TNFalpha protein levels in the kidneys of compared with similarly treated wild-type mice
• however, DEXA treatment restores normal levels
• DOCA-salt-treated mice exhibit a more monocyte/macrophage and CD3+ T cell infiltration than similarly treated wild-type mice
• however, DEXA treatment prevents kidney inflammation




Genotype
MGI:4417977
hm2
Allelic
Composition
Trpv1tm1Jul/Trpv1tm1Jul
Genetic
Background
B6.129X1-Trpv1tm1Jul/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation (1 available); any Trpv1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after ischemia and during reperfusion, mice exhibit impaired recovery with lower left ventricular end diastolic pressure and higher left ventricle developed pressure and coronary flow compared with similarly treated wild-type mice
• however, treatment with calcitonin gene-related peptide or substance P improves postischemic recovery as in wild-type mice
• mice treated with PAR2-AP alone or in combination with capsaicin fail to exhibit thermal hyperalgesia unlike similarly treated wild-type mice (J:96901)
• anandamide-treated mice fail to exhibit phase I (decreased mean arterial blood pressure, cardiac contractility, and heart rate) and exhibit a reduced phase II pressor response compared with similarly treated wild-type mice (J:105525)
• capsaicin-treatment mice fail to exhibit a anandamide-like phase I and II response as in similarly treated wild-type mice (J:105525)
• however, the prolonged hypotensive response to anandamide-treatment is normal (J:105525)
• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice (J:128319)
• capsaicin-treated mice fail to exhibit synaptic depression unlike similarly treated wild-type mice (J:132936)
• 12-(S)-HPETE fails to depress synaptic transmission at excitatory synapses in interneurons unlike in wild-type mice (J:132936)

nervous system
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice
• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice
• in response to hyperosmotic stimulation, supraoptic nucleus neurons fail to generate an increase in membrane conductance and depolarizing potentials unlike similarly treated wild-type cells
• impulse frequency of action potentials in colon sensory neurons at 45 degrees Celsius is lower than in similarly treated wild-type cells
• colon sensory neurons fail to exhibit a sustained-type current response to protons unlike similarly treated wild-type cells
• colon sensory neurons fail to exhibit a temperature sensitive response or 5-HT effect unlike similarly treated wild-type cells
• temperatures below 50 degrees Celsius generate few action potentials in colon sensory neurons unlike in similarly treated wild-type cells
• capsaicin-treated mice fail to exhibit synaptic depression unlike similarly treated wild-type mice
• 12-(S)-HPETE fails to depress synaptic transmission at excitatory synapses in interneurons unlike in wild-type mice

cardiovascular system
• after ischemia and during reperfusion
• after ischemia and during reperfusion
• after ischemia and during reperfusion
• after ischemia and during reperfusion, mice exhibit impaired recovery with lower left ventricular end diastolic pressure and higher left ventricle developed pressure and coronary flow compared with similarly treated wild-type mice
• however, treatment with calcitonin gene-related peptide or substance P improves postischemic recovery as in wild-type mice

growth/size/body
• mice fed a high fat diet and treated with capsaicin fail to exhibit a decrease in body weight compared with similarly treated wild-type mice

behavior/neurological
N
• mice exhibit normal tactile hypersensitivity and allodynia following spinal nerve ligation (J:132700)
• mice exhibit normal water consumption and ethanol-induced conditioned taste aversion (J:153529)
• mice exhibit greater preference for ethanol than wild type mice in a two-bottle test
• mice consume more ethanol than wild-type mice in a two-bottle test
• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice
• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice
• however, mice exhibit normal acute ethanol withdrawal severity
• duration of loss of righting reflex following ethanol consumption (at 3.2 g/kg and 3.4 g/kg but not 3.8 g/kg) is shorter than in similarly treated wild-type mice
• recovery from impaired coordination following ethanol consumption is faster than for similarly treated wild-type mice
• following induction of colonic distention, mice fail to exhibit zymogen-induced behavioral hypersensitivity, as measured by visceral nociception, unlike similarly treated wild-type mice
• mice treated with PAR2-AP alone or in combination with capsaicin fail to exhibit thermal hyperalgesia unlike similarly treated wild-type mice

taste/olfaction
• at high concentrations, mice exhibit a less aversion to FeSO4 than wild-type mice
• mice exhibit less aversion to 10 mM CuSO4 than wild-type mice
• however, aversion to ZnSO4 is normal

integument
• mice exhibit delays in the onset of catagen and telogen compared with wild-type mice
• however, follicle cycling is normal once initiated
• at P19, mice exhibit a retardation in catagen compared with wild-type mice
• slightly retarded at P25

cellular
• neuronal precursor cell proliferation in the dorsal ganglion and subventricular zone (SVZ) is increased compared to in wild-type mice
• SR141716A does not affected proliferation in the dorsal ganglion and decreases proliferation in the SVZ unlike in similarly treated wild-type mice




Genotype
MGI:2655322
hm3
Allelic
Composition
Trpv1tm1Jul/Trpv1tm1Jul
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation (1 available); any Trpv1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• following an injection of a hypertonic solution, mice drink water less than similarly treated wild-type mice
• reduced thermal hypersensitvitiy following inflammation
• mutants show normal responses to noxious mechanical stimuli but exhibit no vanilloid-evoked pain behavior, are impaired in the detection of painful heat, and show little thermal hypersensitivity in the setting of inflammation (J:61534)
• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type (J:197482)
• mutants exhibit no vanilloid (capsaicin and resiniferatoxin) evoked pain behavior: no behavioral response and less swelling with vanilloid injection into plantar skin of hind paw, no aversive response to drinking capsaicin supplemented water, and no reduction in temperature in response to capsaicin injection
• mutants exhibit reduced sensitivity to painful heat in behavioral tests, with longer mean withdrawal latencies in the tail immersion test at temperatures greater than 48 degrees Celcius and longer response latencies at temperatures greater than 50 degrees Celcius in the hot plate assay (J:61534)
• mutants treated with mustard oil show little or no change in hot plate latency (J:61534)
• mice show increased latencies (impaired nociceptive response) in tail-immersion and hot plate paradigms (J:197482)

nervous system
• in response to osmotic stimulation, organum vasculosum lamina terminalis neurons fail to exhibit changes in membrane potential or conductance unlike similarly treated wild-type cells
• in response to osmotic stimulation, organum vasculosum lamina terminalis neurons fail to exhibit an increase in action potential firing compared with similarly treated wild-type cells
• sensory neurons and primary afferent fibers show a reduction in proton (pH5) sensitivity in vitro (acid-evoked nociception)
• incidence of noxious heat-evoked currents of the moderate-threshold (greater than 43 degrees Celcius) class is reduced in cultured sensory neurons or sensory nerve fibers but high-threshold responses remain intact
• vanilloid compounds, capsaicin and resiniferatoxin, are completely inactive on neurons from mutants, showing no increases in calcium or inward currents
• mutants treated with mustard oil show little or no chmutants treated with mustard oil show no enhancement of thermally evoked responses in wide dynamic range neurons of the lumbar dorsal horn

adipose tissue
• when fed a high fat diet compared with similarly treated wild-type mice
• when fed a high fat diet compared with similarly treated wild-type mice
• when fed a high fat diet compared with similarly treated wild-type mice

growth/size/body
• when fed a high fat diet compared with similarly treated wild-type mice

homeostasis/metabolism
• when fed a high fat diet compared with similarly treated wild-type mice
• whether fed a standard or high fat diet, cold-treated mice do not exhibit the drop in body temperature observed in similarly treated wild-type mice

liver/biliary system
• when fed a high fat diet, mice exhibit reduced hepatic fat content and reduced lipid droplets compared with similarly treated wild-type mice

integument
• when fed a high fat diet compared with similarly treated wild-type mice




Genotype
MGI:3834761
hm4
Allelic
Composition
Trpv1tm1Jul/Trpv1tm1Jul
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jul mutation (1 available); any Trpv1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal circadian core body temperature, response to warm or cold exposure, and ethanol-induced hypothermia
• the amplitude of the fever response to LPS-treatment is blunted compared to in similarly treated wild-type mice
• skin carcinogenesis is enhanced in mice treated with DMBA and TPA over a period of 21 weeks
• about 75% of mice developed skin tumors compared to under 25% for controls, with the tumors being larger and more numerous

renal/urinary system
• increased frequency of non-voiding contractions
• the frequency of and strength voiding contractions were similar those of wild-type littermates

neoplasm
• skin carcinogenesis is enhanced in mice treated with DMBA and TPA over a period of 21 weeks
• about 75% of mice developed skin tumors compared to under 25% for controls, with the tumors being larger and more numerous

immune system
• the amplitude of the fever response to LPS-treatment is blunted compared to in similarly treated wild-type mice




Genotype
MGI:5506549
cn5
Allelic
Composition
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+
Trpv1tm1Jul/Trpv1tm1Jul
Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde mutation (1 available); any Gt(ROSA)26Sor mutation (745 available)
Tg(Mrgpra3-GFP/cre)#Xzd mutation (0 available)
Trpv1tm1Jul mutation (1 available); any Trpv1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type
• mice have impaired nociceptive responses, showing increased latencies in tail-immersion and hot plate paradigms

integument
• robust itch behavior is observed after cheek injection of capsaicin compared to little hindpaw scratching seen in treated wild-type




Genotype
MGI:5697887
cx6
Allelic
Composition
Trpv1tm1Jul/Trpv1tm1Jul
Pirttm2Xzd/Pirt+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pirttm2Xzd mutation (0 available); any Pirt mutation (10 available)
Trpv1tm1Jul mutation (1 available); any Trpv1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• complete absence of Ca+2 signals in sensory neurons after capsaicin stimulation





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory