Analysis Tools
behavior/neurological
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• in a discrete T-maze paradigm with a 5-second delay, mice show reduced alternation indicating impaired spatial working memory
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• about 25% of mice develop skin lesions caused by self-injurious, over-grooming behavior
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• mice exhibit enhanced startle amplitudes, indicative of increased sensory-motor reactivity
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• mice exhibit forepaw clasping/wringling behavior during tail suspension at a greater rate than controls
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• activity patterns across the light-dark cycle indicate increased locomotor activity, which is more apparent during the light cycle
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• in a mating paradigm, males initiate less social contact with an unfamiliar wild-type female than control males
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• in a same-sex 3 chambered social approach/avoidance paradigm, males show reduced sociability compared to controls
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• males emit fewer vocalizations during female social interaction than control males and the peak frequency of calls emitted is lower than in controls
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hearing/vestibular/ear
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• the phase-locked early auditory gamma-band response is reduced indicating deficits in neural synchrony
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• mice show a 10-15% delay in the latency of the N1 component of the auditory-evoked response, however the amplitudes of P1 and N1 peaks are not different
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nervous system
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:203256 | ||
