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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grin1tm1Stl
targeted mutation 1, Susumu Tonegawa
MGI:1928270
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Grin1tm1Stl/Grin1tm1Stl either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) MGI:2175049
cn2
Emx1tm1(cre)Ito/Emx1+
Grin1tm1Stl/Grin1tm2Stl
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3581525
cx3
Grin1tm1Stl/Grin1+
Nf1tm1Tyj/Nf1+
involves: 129S2/SvPas * C57BL/6J MGI:3580057


Genotype
MGI:2175049
hm1
Allelic
Composition
Grin1tm1Stl/Grin1tm1Stl
Genetic
Background
either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Stl mutation (0 available); any Grin1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 10-20 hours after birth, pups are either thrown out of the nest unattened or are dead inside the nest

behavior/neurological
• do not have milk in stomachs indicating impaired suckling reflexes
• severely ataxic and cannot support body weight on their hindlimbs

homeostasis/metabolism
• cyanosis appeared shortly before death

respiratory system
• observed increased apnea within several hours of birth

nervous system
• absence of barrelettes in the brainstem trigeminal complex
• absent slow NMDA receptor-mediated (sensitive to AP5) postsynaptic currents




Genotype
MGI:3581525
cn2
Allelic
Composition
Emx1tm1(cre)Ito/Emx1+
Grin1tm1Stl/Grin1tm2Stl
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (19 available)
Grin1tm1Stl mutation (0 available); any Grin1 mutation (24 available)
Grin1tm2Stl mutation (1 available); any Grin1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• thalamocortical afferents corresponding to large whiskers form patterns and display critical period plasticity but their pattering is not as well defined as in controls
• thalamocortical patterns corresponding to sinus hairs and digits are mostly absent
• dendritic fields of spiny stellate cells do not orient toward thalamocortical axon terminal patches, instead they radiate in all directions covering larger territories, exhibiting profuse branching with increased spine density
• cortex thalamocortical axons form smaller patches and individual axon terminal branching is not as well developed as in controls
• septal areas between thalamocortical axon patches are enlarged
• decreased total axonal length, number of branches (by about 50%) and lateral:vertical field span ratio of thalamocortical axons
• barrels and barrel boundaries do not develop even at sites where thalamocortical afferents cluster (J:64064)
• layer IV cells of the somatosensory cortex fail to segregate into barrels (J:80900)
• barrel cortex lacks NMDA receptor-mediated excitation

growth/size/body
• average body weight was about 70% of that of controls at P7
• low growth rate




Genotype
MGI:3580057
cx3
Allelic
Composition
Grin1tm1Stl/Grin1+
Nf1tm1Tyj/Nf1+
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Stl mutation (0 available); any Grin1 mutation (24 available)
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• spatial learning impairment in Morris Water Maze Test, however normal long term memory in cued fear conditioning test and normal nociception

Mouse Models of Human Disease
OMIM ID Ref(s)
Neurofibromatosis, Type I; NF1 162200 J:38703





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory