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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgf10tm1Wss
targeted mutation 1, W Scott Simonet
MGI:1927833
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fgf10tm1Wss/Fgf10tm1Wss either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss) MGI:2175021
hm2
Fgf10tm1Wss/Fgf10tm1Wss involves: 129X1/SvJ MGI:3656008
hm3
Fgf10tm1Wss/Fgf10tm1Wss involves: 129X1/SvJ * C57BL/6 MGI:3662843
hm4
Fgf10tm1Wss/Fgf10tm1Wss involves: 129X1/SvJ * CF-1 MGI:3656036
ht5
Fgf10tm1Wss/Fgf10+ involves: 129 * 129X1/SvJ * BALB/c * C57BL/6 MGI:3775808
ht6
Fgf10tm1Wss/Fgf10+ involves: 129X1/SvJ MGI:5816495
ht7
Fgf10tm1Wss/Fgf10tm1.1Sms involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ MGI:4456411
cn8
Fgf10tm1Wss/Fgf10+
Fgfr2tm2Dsn/Fgfr2+
Tg(Pgk1-cre)1Lni/0
involves: 129 * 129X1/SvJ * BALB/c * C57BL/6 MGI:3775807
cx9
Fgf3tm1Mrc/Fgf3tm1Mrc
Fgf10tm1Wss/Fgf10tm1Wss
involves: 129S7/SvEvBrd * 129X1/SvJ MGI:3662759
cx10
Fgf3tm1Mrc/Fgf3tm1Mrc
Fgf10tm1Wss/Fgf10+
involves: 129S7/SvEvBrd * 129X1/SvJ MGI:3662760
cx11
Fgf3tm1Mrc/Fgf3+
Fgf10tm1Wss/Fgf10tm1Wss
involves: 129S7/SvEvBrd * 129X1/SvJ MGI:3662761


Genotype
MGI:2175021
hm1
Allelic
Composition
Fgf10tm1Wss/Fgf10tm1Wss
Genetic
Background
either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• crown-rump lengths of E17.5 fetuses are on average 12% shorter than controls

respiratory system
• initial branching of the primordial bronchi is absent
• pulmonary bronchiolar development does not occur
• initial tracheal development is normal, however the trachea terminates at the level of the thymus and no main-stem bronchi or subsequent pulmonary bronchiolar and alveolar development occurs
• alveolar development does not occur

limbs/digits/tail
• complete absence of budding limbs at E9.5 and E10.5

skeleton
• exhibit only a rudimentary cartilaginous pelvic girdle at E18.5

embryo
• complete absence of budding limbs at E9.5 and E10.5




Genotype
MGI:3656008
hm2
Allelic
Composition
Fgf10tm1Wss/Fgf10tm1Wss
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Palatal abnormalities in Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn and Fgf10tm1Wss/Fgf10tm1Wss mice

vision/eye

respiratory system
• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching
• maxillary sinus gland is absent
• branching of the distal lateral nasal glands is reduced at E17.5
• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen

reproductive system
• bulbourethral does not form in mutants and in grafting experiments, the caudal urethra does not produce the bulbourethral gland
• prostatic rudiments from homozygous mice transplanted into intact male hosts grow very little, but show some signs of prostatic differentiation
• wild-type hosts grafted with homozygous mutant testes show smaller growth of the dorsolateral prostate and coagulating gland
• prostate is not visible at the end of gestation
• seminal vesicle is absent in mutants and grafted mutant caudal Wolffian duct into nude mice shows very limited ability to develop into seminal vesicle
• mutants in which the caudal Wolffian duct is absent exhibit a cystic epididymis

endocrine/exocrine glands
• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching
• maxillary sinus gland is absent
• branching of the distal lateral nasal glands is reduced at E17.5
• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen
• bulbourethral does not form in mutants and in grafting experiments, the caudal urethra does not produce the bulbourethral gland
• prostatic rudiments from homozygous mice transplanted into intact male hosts grow very little, but show some signs of prostatic differentiation
• wild-type hosts grafted with homozygous mutant testes show smaller growth of the dorsolateral prostate and coagulating gland
• prostate is not visible at the end of gestation
• seminal vesicle is absent in mutants and grafted mutant caudal Wolffian duct into nude mice shows very limited ability to develop into seminal vesicle

craniofacial
• palates are short, squared in shape
• palatal epithelium is thin and lacks stratification and in some cases the epithelial covering at the tip of the palatal projection has disintegrated and the underlying mesenchymal cells have broken through into the oral cavity
• epithelial cell proliferation is reduced in all areas of the palate at E12 and E13
• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%
• exhibit an increase in apoptotic cells in the palate at E13
• exhibit a complete, wide cleft of the secondary palate; palate abnormalities first noted at E13
• do not have finger-like projections lateral to the tongue
• exhibit epithelial fusions between the nasal surface of the palate and the tongue, as well as the oral surface of the palate and the mandible
• exhibit isolated epithelial outgrowths on the dorsal surface of the tongue
• exhibit partial ankylosis of the tongue, with defective epithelialization between the floor of the mouth and tongue
• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching
• maxillary sinus gland is absent
• branching of the distal lateral nasal glands is reduced at E17.5
• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen

digestive/alimentary system
• palates are short, squared in shape
• palatal epithelium is thin and lacks stratification and in some cases the epithelial covering at the tip of the palatal projection has disintegrated and the underlying mesenchymal cells have broken through into the oral cavity
• epithelial cell proliferation is reduced in all areas of the palate at E12 and E13
• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%
• exhibit an increase in apoptotic cells in the palate at E13
• exhibit a complete, wide cleft of the secondary palate; palate abnormalities first noted at E13
• do not have finger-like projections lateral to the tongue
• exhibit epithelial fusions between the nasal surface of the palate and the tongue, as well as the oral surface of the palate and the mandible
• exhibit isolated epithelial outgrowths on the dorsal surface of the tongue
• exhibit partial ankylosis of the tongue, with defective epithelialization between the floor of the mouth and tongue

renal/urinary system
• both males and females develop severe proximal hypospadias as early as E13.5

embryo
• homozygous urogenital sinuses do not form buds or ducts when cultured with testosterone alone as in controls and grafts of homozygous urogenital sinuses into nude mice exhibit no development of branching ducts
• the entire Wolffian duct is present at E15 or before, but by E18 the caudal portion of the Wolffian duct is absent in the majority of males
• when present, the Wolffian duct is much thinner

integument
• exhibit mild epidermal hypoplasia, much less severe than seen in homozygous Fgfr2 mutants and do not exhibit any hair follicle defects

growth/size/body
• palates are short, squared in shape
• palatal epithelium is thin and lacks stratification and in some cases the epithelial covering at the tip of the palatal projection has disintegrated and the underlying mesenchymal cells have broken through into the oral cavity
• epithelial cell proliferation is reduced in all areas of the palate at E12 and E13
• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%
• exhibit an increase in apoptotic cells in the palate at E13
• exhibit a complete, wide cleft of the secondary palate; palate abnormalities first noted at E13
• do not have finger-like projections lateral to the tongue
• exhibit epithelial fusions between the nasal surface of the palate and the tongue, as well as the oral surface of the palate and the mandible
• exhibit isolated epithelial outgrowths on the dorsal surface of the tongue
• exhibit partial ankylosis of the tongue, with defective epithelialization between the floor of the mouth and tongue
• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching
• maxillary sinus gland is absent
• branching of the distal lateral nasal glands is reduced at E17.5
• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen




Genotype
MGI:3662843
hm3
Allelic
Composition
Fgf10tm1Wss/Fgf10tm1Wss
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• abnormal cecum development; develop a mesenchymal bud at the ileo-colonic junction but no epithelial budding or expansion into the cecal mesenchume at E12.5
• at E14.5, show a continued mesenchymal bud with no epithelial budding which appears to degenerate by E18.5




Genotype
MGI:3656036
hm4
Allelic
Composition
Fgf10tm1Wss/Fgf10tm1Wss
Genetic
Background
involves: 129X1/SvJ * CF-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• the cochlea is shortened but otherwise normal including the organ of Corti
• the short canal emerging from the horizontal crista extend vertically toward the cochlea rather than horizontal, toward the posterior canal
• a blind-ending stub is formed instead of the horizontal canal
• complete absence of all aspects of the posterior canal system; no posterior crista, no posterior canal, and no myelinated nerve fiber to the area of the posterior canal
• the anterior and horizontal cristae are much smaller and barely segregated from the utricle
• the anterior canal is largely continuous with the utricle without forming a recognizable canal
• enlarged bulbs on the kinocilia
• remaining hair cells of vestibular sensory epithelia show some aberrations in the formation of apical stereocilia
• in most mutants, the utricle forms a central recess rather than a flat sheet of cells
• the saccule shows slight dismorphogenesis, is somewhat smaller, and is in a somewhat different position, further away from the cochlea

nervous system
• enlarged bulbs on the kinocilia
• remaining hair cells of vestibular sensory epithelia show some aberrations in the formation of apical stereocilia
• the posterior canal sensory neurons from initially and project rather normally by E11.5 but they disappear within 2 days

craniofacial

cellular
• enlarged bulbs on the kinocilia

growth/size/body




Genotype
MGI:3775808
ht5
Allelic
Composition
Fgf10tm1Wss/Fgf10+
Genetic
Background
involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Submandibular gland is hypoplastic in Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0, Fgf10tm1Wss/Fgf10+, and Fgf10tm1Wss/Fgf10+ Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 mice

endocrine/exocrine glands

digestive/alimentary system




Genotype
MGI:5816495
ht6
Allelic
Composition
Fgf10tm1Wss/Fgf10+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

endocrine/exocrine glands
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

growth/size/body
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

respiratory system
• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5
• branching of the lateral nasal glands is reduced at E17.5
• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
LADD syndrome DOID:0050331 OMIM:149730
J:237227




Genotype
MGI:4456411
ht7
Allelic
Composition
Fgf10tm1Wss/Fgf10tm1.1Sms
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1.1Sms mutation (0 available); any Fgf10 mutation (11 available)
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

hearing/vestibular/ear
• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

respiratory system
• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles




Genotype
MGI:3775807
cn8
Allelic
Composition
Fgf10tm1Wss/Fgf10+
Fgfr2tm2Dsn/Fgfr2+
Tg(Pgk1-cre)1Lni/0
Genetic
Background
involves: 129 * 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
Fgfr2tm2Dsn mutation (0 available); any Fgfr2 mutation (23 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Submandibular gland is hypoplastic in Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0, Fgf10tm1Wss/Fgf10+, and Fgf10tm1Wss/Fgf10+ Fgfr2tm2Dsn/Fgfr2+ Tg(Pgk1-cre)1Lni/0 mice

endocrine/exocrine glands
• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant
• submandibular salivary glands are smaller than either single heterozygous mutant

digestive/alimentary system
• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant
• submandibular salivary glands are smaller than either single heterozygous mutant




Genotype
MGI:3662759
cx9
Allelic
Composition
Fgf3tm1Mrc/Fgf3tm1Mrc
Fgf10tm1Wss/Fgf10tm1Wss
Genetic
Background
involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
Fgf3tm1Mrc mutation (0 available); any Fgf3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• embryos either have a unilateral microvesicle or lack any sign of otic vesicle formation
• otic development arrests prior to invagination of the otic cup to form the otic vesicle

limbs/digits/tail
• E10.5 embryos have short dorsally curved tails




Genotype
MGI:3662760
cx10
Allelic
Composition
Fgf3tm1Mrc/Fgf3tm1Mrc
Fgf10tm1Wss/Fgf10+
Genetic
Background
involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
Fgf3tm1Mrc mutation (0 available); any Fgf3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• otic vesicles are more ventrally localized than in controls
• small otic vesicles at E9.5; phenotype is more severe than in mutants homozygous for Fgf10 and heterozygous for Fgf3




Genotype
MGI:3662761
cx11
Allelic
Composition
Fgf3tm1Mrc/Fgf3+
Fgf10tm1Wss/Fgf10tm1Wss
Genetic
Background
involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Wss mutation (0 available); any Fgf10 mutation (11 available)
Fgf3tm1Mrc mutation (0 available); any Fgf3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• small otic vesicles at E9.5; phenotype is not as severe as in mutants homozygous for Fgf3 and heterozygous for Fgf10





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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory