Mouse Genome Informatics
hm1
    Itgb6tm1Des/Itgb6tm1Des
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• treatment with angiotensin II and aldosterone reduces macrophage invasion where as it increases macrophage invasion in wild-type mice
• tubulointerstitial damage and fibrosis induction are less than in wild-type mice following kidney obstruction


Mouse Genome Informatics
hm2
    Itgb6tm1Des/Itgb6tm1Des
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Abnormal vascular development in Tgfb1tm1Jmu/Tgfb1tm1Jmu mice and fewer Langerhans cells in Tgfb1tm1Jmu/Tgfb1tm1Jmu and Itgb6tm1Des/Itgb6tm1Des mice

immune system
• Langerhans cells are less abundant in back epidermis
• Langerhans cells are absent from ear epidermis
• mild inflammation occurs in the lung and skin

hematopoietic system
• Langerhans cells are less abundant in back epidermis
• Langerhans cells are absent from ear epidermis


Mouse Genome Informatics
hm3
    Itgb6tm1Des/Itgb6tm1Des
involves: 129S4/SvJae * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
respiratory system
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
• increased numbers of eosinophiles recovered by bronchoalveolar lavage

immune system
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
• increased numbers of eosinophiles recovered by bronchoalveolar lavage


Mouse Genome Informatics
hm4
    Itgb6tm1Des/Itgb6tm1Des
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice

respiratory system
• mice exhibit increased airway responsiveness to acetylcholine
• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium
• however, mice do not display any overt signs of lung infection

immune system
• mice exhibit increased airway responsiveness to acetylcholine

integument
• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs
• however, by 20 to 30 days hair growth on the head and neck resumes
• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate
• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes

Mouse Models of Human Disease
OMIM IDRef(s)
Asthma, Susceptibility to 600807 J:33139


Mouse Genome Informatics
hm5
    Itgb6tm1Des/Itgb6tm1Des
involves: 129T2/SvEms
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
respiratory system
• normal alveolar size at 2 months of age, however spontaneously developed progressive alveolar enlargement over time
• developed pulmonary emphysema over time

Mouse Models of Human Disease
OMIM IDRef(s)
Emphysema, Hereditary Pulmonary 130700 J:89578


Mouse Genome Informatics
cx6
    Itgb6tm1Des/Itgb6tm1Des
Mmp12tm1Sds/Mmp12tm1Sds

involves: 129/Sv * 129T2/SvEms
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

respiratory system
N
• did not exhibit alveolar enlargement and did not develop emphysema (J:89578)
• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

integument
• developed patchy juvenile baldness associated with skin inflammation

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Emphysema, Hereditary Pulmonary 130700 J:89578


Mouse Genome Informatics
cx7
    Itgb6tm1Des/Itgb6tm1Des
Tg(SFTPC-ITGB6)1Des/?

involves: 129S4/SvJae * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
respiratory system
N
• bronchoalveolar lavage abnormalities are largely corrected (J:51592)
• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined
• less frequent than in mice only homozygous for Itgb6tm1Des

immune system
• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined
• less frequent than in mice only homozygous for Itgb6tm1Des

integument
• inflammatory baldness observed