Phenotypes associated with this allele
Allelic Composition |
Itgb6tm1Des/Itgb6tm1Des
|
|
Genetic Background |
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation
(0 available);
any
Itgb6 mutation
(31 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation
(0 available);
any
Itgb6 mutation
(31 available)
|
|
|
Abnormal vascular development in Tgfb1tm1Jmu/Tgfb1tm1Jmu mice and fewer Langerhans cells in Tgfb1tm1Jmu/Tgfb1tm1Jmu and Itgb6tm1Des/Itgb6tm1Des mice
immune system
|
• Langerhans cells are less abundant in back epidermis
|
|
• Langerhans cells are absent from ear epidermis
|
|
• mild inflammation occurs in the lung and skin
|
hematopoietic system
|
• Langerhans cells are less abundant in back epidermis
|
|
• Langerhans cells are absent from ear epidermis
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation
(0 available);
any
Itgb6 mutation
(31 available)
|
|
|
respiratory system
|
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
• increased numbers of eosinophiles recovered by bronchoalveolar lavage
|
immune system
|
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
• increased numbers of eosinophiles recovered by bronchoalveolar lavage
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation
(0 available);
any
Itgb6 mutation
(31 available)
|
|
|
Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice
respiratory system
|
• mice exhibit increased airway responsiveness to acetylcholine
|
|
• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium
• however, mice do not display any overt signs of lung infection
|
immune system
|
• mice exhibit increased airway responsiveness to acetylcholine
|
integument
|
• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs
• however, by 20 to 30 days hair growth on the head and neck resumes
|
|
• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate
|
|
• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation
(0 available);
any
Itgb6 mutation
(31 available)
|
|
|
respiratory system
|
• normal alveolar size at 2 months of age, however spontaneously developed progressive alveolar enlargement over time
|
|
• developed pulmonary emphysema over time
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation
(0 available);
any
Itgb6 mutation
(31 available)
Mmp12tm1Sds mutation
(1 available);
any
Mmp12 mutation
(34 available)
|
|
|
immune system
|
• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice
|
respiratory system
N |
• did not exhibit alveolar enlargement and did not develop emphysema
|
|
• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice
|
integument
|
• developed patchy juvenile baldness associated with skin inflammation
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation
(0 available);
any
Itgb6 mutation
(31 available)
Tg(SFTPC-ITGB6)1Des mutation
(0 available)
|
|
|
respiratory system
N |
• bronchoalveolar lavage abnormalities are largely corrected
|
|
• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined
• less frequent than in mice only homozygous for Itgb6tm1Des
|
immune system
|
• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined
• less frequent than in mice only homozygous for Itgb6tm1Des
|
integument
|
• inflammatory baldness observed
|