Phenotypes associated with this allele

• Allele Symbol: Adrb3^tm1Lowl
• Allele Name: targeted mutation 1, Bradford B Lowell
• Allele ID: MGI:1860610
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adrb3^tm1Lowl/Adrb3^tm1Lowl	FVB/N-Adrb3^tm1Lowl	MGI:2386301
cx2	Adrb1^tm1Bkk/Adrb1^tm1Bkk Adrb2^tm1Bkk/Adrb2^tm1Bkk Adrb3^tm1Lowl/Adrb3^tm1Lowl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N	MGI:2388265

Genotype
MGI:2386301

hm1

• Allelic Composition: Adrb3^tm1Lowl/Adrb3^tm1Lowl
• Genetic Background: FVB/N-Adrb3^tm1Lowl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:30060 )

• body fat stores are increased by 34% in males, however epididymal fat pads weights are normal

• body fat stores are increased by 131% in females

increased parametrial fat pad weight ( J:30060 )

• parametrial fat pads weigh 99% more than in controls

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:30060 )

• mutants exhibit complete loss of beta3-adrenergic receptor agonist (CL 316,243)-induced stimulation of adenylate cyclase activity, lipolysis, increase of CO₂ consumption, serum FFA levels, plasma insulin levels, and reduction of blood glucose levels and food intake

• absence of isoproterenol-stimulated lipolysis in adipocytes in the presence of PIA, an A1 adenosine receptor agonist

Genotype
MGI:2388265

cx2

• Allelic Composition: Adrb1^tm1Bkk/Adrb1^tm1Bkk; Adrb2^tm1Bkk/Adrb2^tm1Bkk; Adrb3^tm1Lowl/Adrb3^tm1Lowl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

adipose tissue

increased total body fat amount ( J:79309 )

• obesity attributable to increased fat mass

abnormal brown adipose tissue morphology ( J:79309 )

• interscapular brown adipose tissue (BAT) enlarged and pale

• BAT contained large cells with unilocular triglyceride deposits

increased brown fat cell size ( J:79309 )

increased interscapular fat pad weight ( J:79309 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:79309 )

N • normal thyroid hormone levels

growth/size/body

increased body weight ( J:79309 )

obese ( J:79309 )

• on regular Chow diet, mildly obese by 20 weeks; increased obesity on high fat diet (58% of kcal from fat)

• normal food intake and normal physical activity on both normal and high fat diets were observed, however

homeostasis/metabolism

impaired adaptive thermogenesis ( J:79309 )

• normal body temperature under conventional housing conditions, but exposure to cold (22^oC) produced rapid decline in core body temperature

• failure of diet-induced thermogenesis

increased circulating leptin level ( J:79309 )

• increased leptin levels

decreased oxygen consumption ( J:79309 )

• reduced metabolic rate, measured by O₂ consumption

• isoproterenol exposure failed to increase O₂ consumption

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:79309