Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tal1Hpt mutation
(2 available);
any
Tal1 mutation
(33 available)
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pigmentation
integument
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• coat appearance of a homozygote can be discerned from a heterozygote only by breeding tests
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• the permanent coat may be normal with a few bare patches
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• some homozygotes have a sparse permanent coat with extensive bare patches
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tal1Hpt mutation
(2 available);
any
Tal1 mutation
(33 available)
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mortality/aging
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• die by 6 to 8 days of gestation
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embryo
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• death is associated with abnormalities of ectodermal derivatives
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tal1Hpt mutation
(2 available);
any
Tal1 mutation
(33 available)
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pigmentation
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• the skin is littered with heavily pigmented debris
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integument
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• permanent coat of some may be normal but have a few bare patches
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• the permanent coat of some heterozygotes is sparse with extensive bare patches
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• the skin is littered with heavily pigmented debris
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tal1Hpt mutation
(2 available);
any
Tal1 mutation
(33 available)
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renal/urinary system
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• model for mechanisms of progressive noninflammatory renal disease
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• disorganization, swelling, and fusion of the foot processes
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• condition is progressive and by 6 months of age most glomeruli show advanced sclerosis
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• results from progressive glomerulosclerosis
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cardiovascular system
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• increased systolic pressure by 3 months of age
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pigmentation
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• mosaicism for pigmented and unpigmented areas is observed a few days after birth
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hematopoietic system
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• occurs by 40 weeks of age
• assumed secondary to renal failure
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• before one year of age counts are normal
• at 68 weeks of age the leukocyte count is significanlty decreased with a slight decrease in lymphocytes and increase in neutrophils
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growth/size/body
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• mutants at all ages are smaller than age and sex-matched controls
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immune system
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• before one year of age counts are normal
• at 68 weeks of age the leukocyte count is significanlty decreased with a slight decrease in lymphocytes and increase in neutrophils
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integument
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• patchy absence of hair throughout life
• pigmented and unpigmented areas observed soon after birth correspond to future areas of abnormal and normal hair growth respectively
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• follicles may not produce hairs or hairs may not erupt
• keratin plugs follicles
• abnormal follicles are larger than normal
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• reduced numbers of normal follicles can be detected as early as E14
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• mosaicism for pigmented and unpigmented areas is observed a few days after birth
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muscle
Analysis Tools