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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nfkbiatm1Bal
targeted mutation 1, David Baltimore
MGI:1858084
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nfkbiatm1Bal/Nfkbiatm1Bal involves: 129S4/SvJae * C57BL/6J MGI:3034093
cx2
Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 MGI:3053046
cx3
Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkbiatm1Bal/Nfkbiatm1Bal
involves: 129S4/SvJae * C57BL/6J MGI:3034094


Genotype
MGI:3034093
hm1
Allelic
Composition
Nfkbiatm1Bal/Nfkbiatm1Bal
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death occurred around the 1st week of age

growth/size/body
• although of normal size at birth, homozygotes became noticeably smaller than normal by 3-4 days of age
• by 7 days of age homozygotes were severely runted (1/3 normal weight)

hematopoietic system
• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age
• atrophy in mice over 6 days of age
• 3 fold increase in peripheral WBC count - about 95% neutrophils
• small size by day 2 with a worsening size reduction until death

immune system
• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age
• atrophy in mice over 6 days of age
• 3 fold increase in peripheral WBC count - about 95% neutrophils
• small size by day 2 with a worsening size reduction until death

integument
• poorly defined basal layer
• significant sloughing

cellular
• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age

endocrine/exocrine glands
• atrophy in mice over 6 days of age




Genotype
MGI:3053046
cx2
Allelic
Composition
Nfkbiatm1Bal/Nfkbiatm1Bal
Nfkbietm1Syme/Nfkbietm1Syme
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (6 available)
Nfkbietm1Syme mutation (0 available); any Nfkbie mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double homozygotes are born alive but remain cyanotic and die within 10-30 minutes

hematopoietic system
• increased among B cells
• increased among T cells in transition from double positive to single positive
• decreased numbers of B cell precursors
• very low numbers of immature B cells
• development from the double positive stage to the single positive stage is reduced
• clear reduction of B220+CD43- cells

immune system
• increased among B cells
• increased among T cells in transition from double positive to single positive
• decreased numbers of B cell precursors
• very low numbers of immature B cells
• development from the double positive stage to the single positive stage is reduced
• clear reduction of B220+CD43- cells

cellular
• increased among B cells
• increased among T cells in transition from double positive to single positive




Genotype
MGI:3034094
cx3
Allelic
Composition
Nfkb1tm1Bal/Nfkb1tm1Bal
Nfkbiatm1Bal/Nfkbiatm1Bal
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (4 available); any Nfkb1 mutation (92 available)
Nfkbiatm1Bal mutation (1 available); any Nfkbia mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival prolonged until 2-4 weeks





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory