Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation
(1 available);
any
Nek1 mutation
(83 available)
|
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mortality/aging
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• Background Sensitivity: by generation N5 on the C57BL/6J background half of the homozygotes die before weaning
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growth/size/body
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• by generation N5 to C57BL/6J there is increased severity of the phenotype including severe dwarfing
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craniofacial
skeleton
Allelic Composition |
Nek1kat/Nek1kat
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Genetic Background |
involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation
(1 available);
any
Nek1 mutation
(83 available)
|
|
|
mortality/aging
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• 22% survive beyond 1 year
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renal/urinary system
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• bilateral polycystic kidney disease with a progressive increase in the number and size of cysts in the kidney cortex, with slower progression than in kat-2J homozygotes
(J:37799)
• cysts seem to be dilated proximal tubules and Bowman spaces
(J:37799)
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nervous system
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• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
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• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
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• at 7 months of age the choroid plexus has multiple large cysts present in the interstitium
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• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
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• most of the olfactory glomerular and external granular layers are absent, and in places are replaced by lacy vacuolated tissue
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• olfactory lobes are approximately half normal size
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growth/size/body
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• bilateral polycystic kidney disease with a progressive increase in the number and size of cysts in the kidney cortex, with slower progression than in kat-2J homozygotes
(J:37799)
• cysts seem to be dilated proximal tubules and Bowman spaces
(J:37799)
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craniofacial
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• foreshortened face, particularly the snout
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hematopoietic system
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• hematocrit is slightly reduced in many young homozygotes and falls progressively after 200 days of age
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Allelic Composition |
Nek1kat/Nek1kat
|
|
Genetic Background |
involves: C3HeB/FeJLe * RBF/Dn |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation
(1 available);
any
Nek1 mutation
(83 available)
|
|
|
mortality/aging
|
• Background Sensitivity: on this mixed genetic background homozygotes survive to adulthood, but still have a shortened lifespan
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reproductive system
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• homozygous females on this mixed background only breed occasionally
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growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation
(1 available);
any
Nek1 mutation
(83 available)
|
|
|
mortality/aging
|
• Background Sensitivity: on the RBF/Dn background, but not the C3HeB/FeJLe x RBF/Dn mixed background, there is a biphasic death pattern wherein approximately half the homozygotes die before weaning and the remainder die by 1 year of age
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craniofacial
growth/size/body
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• all homozygotes are runted with shortened bodies
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renal/urinary system
skeleton
integument