Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1Mlh
• Allele Name: targeted mutation 1, Martin L Hooper
• Allele ID: MGI:1857989
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Mlh/Trp53^tm1Mlh	involves: 129P2/OlaHsd	MGI:3769120
cx2	Apc^Min/Apc^+ Trp53^tm1Mlh/Trp53^tm1Mlh	involves: 129P2/OlaHsd * C57BL/6 * SWR	MGI:5448541
cx3	Rnaseh2b^tm1a(EUCOMM)Wtsi/Rnaseh2b^tm1a(EUCOMM)Wtsi Trp53^tm1Mlh/Trp53^tm1Mlh	involves: 129P2/OlaHsd * C57BL/6N	MGI:5431542

Genotype
MGI:3769120

hm1

• Allelic Composition: Trp53^tm1Mlh/Trp53^tm1Mlh
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:115104 )

N • in an assay of DNA repair capabilities, recovery of reporter activity by Trp53-deficient hepatocytes is not significantly different from that of wild-type cells

abnormal cell cycle ( J:115104 )

decreased enterocyte apoptosis ( J:54082 )

• enterocytes of mice treated with MNNG, temozolomide, and cisplatin exhibit reduced apoptosis compared to cells from similarly treated wild-type mice

digestive/alimentary system

decreased enterocyte apoptosis ( J:54082 )

• enterocytes of mice treated with MNNG, temozolomide, and cisplatin exhibit reduced apoptosis compared to cells from similarly treated wild-type mice

Genotype
MGI:5448541

cx2

• Allelic Composition: Apc^Min/Apc⁺; Trp53^tm1Mlh/Trp53^tm1Mlh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

neoplasm

increased pancreatic acinar cell carcinoma incidence ( J:29664 )

• 22% of mice with abnormalities of the exocrine pancreas also have pancreatic acinar cell adenocarcinoma

• whole pancreatic lobules are involved implicating a stem cell mutation

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:29664 )

• these tumors have lost the wild-type copy of Apc

• 83% of mice of this genotype show a range of exocrine pancreas abnormalities with dysplasia and preneoplastic foci seen in 61% of the mice

• this genotype does not increase the rate or rate of progression of intestinal adenoma

increased pancreatic acinar cell carcinoma incidence ( J:29664 )

• 22% of mice with abnormalities of the exocrine pancreas also have pancreatic acinar cell adenocarcinoma

• whole pancreatic lobules are involved implicating a stem cell mutation

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:29664 )

• 83% of mice of this genotype show a range of exocrine pancreas abnormalities with dysplasia and preneoplastic foci seen in 61% of the mice

• these tumors have lost the wild-type copy of Apc

• this genotype does not increase the rate or rate of progression of intestinal adenoma

Genotype
MGI:5431542

cx3

• Allelic Composition: Rnaseh2b^{tm1a(EUCOMM)Wtsi}/Rnaseh2b^{tm1a(EUCOMM)Wtsi}; Trp53^tm1Mlh/Trp53^tm1Mlh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
• Cell Lines: EPD0087_4_A02

cellular

cellular phenotype ( J:186180 )

N • reduced mouse embryonic fibroblasts cell proliferation is rescued compared to in Rnaseh2b^{tm1a(EUCOMM)Wtsi} homozygotes

abnormal cell nucleus morphology ( J:186180 )

• micronuclei in mouse embryonic fibroblasts

increased cellular sensitivity to alkylating agents ( J:186180 )

chromosomal instability ( J:186180 )

• chromosomal rearrangements in mouse embryonic fibroblasts

embryo

embryo phenotype ( J:186180 )

N • defects in embryo axis, somite development and allantois are rescued compared to in Rnaseh2b^{tm1a(EUCOMM)Wtsi} homozygotes

embryonic growth retardation ( J:186180 )

• partially rescued

decreased embryo size ( J:186180 )

• partially rescued at E9.5

abnormal neural tube closure ( J:186180 )

• in some mice

growth/size/body

embryonic growth retardation ( J:186180 )

• partially rescued

decreased embryo size ( J:186180 )

• partially rescued at E9.5

nervous system

abnormal neural tube closure ( J:186180 )

• in some mice