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Allele Symbol Allele Name Allele ID |
Drd2tm1Low targeted mutation 1, Malcolm J Low MGI:1857875 |
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| Summary |
12 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit decreased horizontal distance and initiation of movement compared with 129S/SvEv mice
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• mice exhibit reduced initiation of movement compared with 129S/SvEv mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit a normal saccharin and quinine preference and locomotor depressant response to SCH-23390 treatment
(J:50787)
• mice exhibit normal basic motor skills without tremor, ataxia, or abnormal stance or posture
(J:103181)
• mice exhibit normal novel odor habituation and odor sensitivity
(J:110704)
• mice exhibit normal tactile responsivity, trigeminal nerve response, or aversive taste reactivity
(J:110704)
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• preference ratio is less than 0.4
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• mice consume less 6% and 10% ethanol solution compared with wild-type mice
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• amphetamine-treated mice fail to exhibit a reduction in prepulse inhibition unlike similarly treated wild-type mice
• however, amphetamine-treated mice exhibit normal reduction in startle reactivity
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• ethanol-treated mice fail to exhibit a locomotor depressant responses unlike similarly treated wild-type mice
• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice
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• during reversal learning trials, mice preserve unreinforced behavior and commit more reversal errors across reversal sessions compared with wild-type mice
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• mice exhibit reduced performance in an odor-driven stimulus-discrimination, operant task compared with wild-type mice
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• mice fail to exhibit an increase in investigation of a novel odor unlike wild-type mice
• mice exhibit an impairment in olfactory discrimination compared with wild-type mice
• mice fail to exhibit increased investigation of an object with a novel scent versus one with s familiar scent unlike wild-type mice
• however, mice exhibit normal exploration behavior
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• mice exhibit reduced acoustic startle response amplitude compared with wild-type mice
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• on days 2 and 3, but not 4, of a rotarod test
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• mice exhibit decreased horizontal distance, initiation of movement, rearing, and duration of horizontal movement compared with C57BL/6 mice
(J:47001)
• mice exhibit reduced mean distance, number of movements, and time in motion compared with wild-type mice
(J:50787)
• however, the movement speed and movement length are normal
(J:50787)
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• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice
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• mice exhibit reduced initiation of movement compared with C57BL/6 mice
(J:47001)
• mice exhibit decreased initiation of movement compared with wild-type mice
(J:103181)
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• mice fail to exhibit an increase in paired pulse ratio during development unlike wild-type mice
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• mice fail to exhibit an increase in paired pulse ratio during development unlike wild-type mice
• mice subjected to high-frequency stimulation fail to exhibit a change in paired pulse ratio unlike similarly treated wild-type mice
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• mice fail to exhibit a decrease in the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) during development unlike wild-type mice
• at P21 to 27, mice exhibit increased spontaneous postsynaptic current compared with wild-type mice
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• amphetamine-treated mice fail to exhibit a reduction in prepulse inhibition unlike similarly treated wild-type mice
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• at P22 to 27, striatal long term depression cannot be induced by high-frequency stimulation unlike in wild-type mice
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• under hypercapnic conditions in male, but not female, mice
• under hypoxic hypercapnic conditions in female, but not male mice
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• under hypoxic hypercapnic conditions in female, but not male mice
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• in male mice at day 2 and 8 of exposure to poikilocapnic hypoxia
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• under hypoxic conditions in female, but not male mice
• under hypercapnic conditions in male, but not female, mice
• under hypoxic hypercapnic conditions in female, but not male mice
• at low levels of hypoxia in male mice
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• mice exhibit increased blood pressure compared with wild-type mice
• during the first 5 minutes after AT1 antagonist treatment, mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• phentolamine-treated mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• BQ-788-treated mice exhibit a decrease in blood pressure unlike in similarly treated wild-type mice
• RES-701-1-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• sarafotoxin S6c-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• however, acute adrenalectomy results in normal blood pressure compared with similarly treated wild-type mice
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• before and after saline loading
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• during the first 5 minutes after AT1 antagonist treatment, mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• phentolamine-treated mice exhibit a greater decrease in blood pressure than similarly treated wild-type mice
• BQ-788-treated mice exhibit a decrease in blood pressure unlike in similarly treated wild-type mice
• RES-701-1-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• sarafotoxin S6c-treated mice exhibit a greater increase in blood pressure than similarly treated wild-type mice
• however, mice respond normally to treatment with an ET(A) or V1 vasopressin receptor antagonist
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• before and after saline loading
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• in male, but not female, mice
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| N |
• mice exhibit normal novel odor habituation and odor sensitivity
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | Parkinson's disease | DOID:14330 |
OMIM:PS168600 |
J:47001 |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4% of methamphetamine-treated mice die compared with 27% of similarly treated wild-type mice
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• methamphetamine-treated mice fail to exhibit an increase in body temperature unlike similarly treated wild-type mice
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• in mice treated with MPTP
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• after 3 months in female mice and after 2 months in male mice
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• cultured pituitary cells from 4 month old male and female mice release less growth hormone than similarly treated wild-type cells
• growth hormone releasing hormone (GHRH)-treated pituitary cells from 8 month old mice release less growth hormone than similarly treated wild-type cells
• however, circulating levels of growth hormone are normal
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• 4% of methamphetamine-treated mice die compared with 27% of similarly treated wild-type mice
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• methamphetamine-treated mice fail to exhibit an increase in body temperature unlike similarly treated wild-type mice
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• in male, but not female, mice
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• maximal growth retardation occurs during the first half of the second month of life
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| N |
• microglia exhibit normal response to LPS
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• in mice treated with MPTP
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• at E15, more neurons enter the cerebral wall compared to in wild-type mice
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• at 2 months in the substantia nigra
• more severe at 16 months in the substantia nigra and striatum
• not suppressed by quinpirole in MPTP-treated mice
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• at E15, the number of GABA+ cells is increased 44% in the presumptive medial prefrontal cortex compared to in wild-type mice
• at E15, GABA+ cell density is increased in the intermediate zone 96% compared to in wild-type mice
• at E15, GABA+ cell density in the ventral zone/subventricular zone is increased 143% compared to in wild-type mice
• however, the numbers of GABA+ cells in the marginal zone and subplate/cortical plate are normal
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• hyper-responsive to LPS treatment with increased production of pro-inflammatory mediators (as measured by RNA levels)
• in cultures of astrocytes and mesencephalic dopaminergic neurons, neurons exhibit reduced survival compared to in cultures with wild-type astrocytes
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• relative to body weight, male mice consume more food than wild-type mice
• however, overall consumption of food is normal
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• methamphetamine-treated mice fail to exhibit an increase in body temperature unlike similarly treated wild-type mice
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• mice exhibit a longer duration of ultrasonic vocalization compared with wild-type mice
• however, mice exhibit normal numbers, duration, and bandwidths of ultrasonic vocalizations
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• at 15 weeks in male, but not female, mice
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• in male and female mice
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• from cultured astrocytes stimulated with conditioned medium of microglia treated with LPS
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• at 15 weeks in male, but not female, mice
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• in male, but not female, mice
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• in male and female mice
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• in mice treated with MPTP
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• at E15, more neurons enter the cerebral wall compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• in aged female mice
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• shorter and thicker than in wild-type mice
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• in aged female mice
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• in 9 of 16 aged female mice
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• pituitary glands exhibit enlarged glandular acini unlike in wild-type mice
• however, pituitary intermediate lobe size is normal
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• older female mice exhibit diffusely enlarged, hyperemic anterior pituitary lobes without focal nodules
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• mice exhibit peliosis unlike wild-type mice
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• fewer gonadotrophs stain positive for beta-follicle stimulating hormone and beta-luteinizing hormone compared to in wild-type mice
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• in the anterior lobe due to hyperplasia and hypertrophy with prominent vascular spaces
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• 4- to 10-fold
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• mice exhibit a 3-fold increase in circulating prolactin levels compared with wild-type mice that is insensitive to treatment with the dopamine receptor 2 antagonist haloperidol
• ages female mice exhibit an age-dependent increase in circulating prolactin levels unlike male mice
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• mice exhibit a 3-fold increase in circulating prolactin levels compared with wild-type mice that is insensitive to treatment with the dopamine receptor 2 antagonist haloperidol
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• pituitary glands exhibit enlarged glandular acini unlike in wild-type mice
• however, pituitary intermediate lobe size is normal
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• older female mice exhibit diffusely enlarged, hyperemic anterior pituitary lobes without focal nodules
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• mice exhibit peliosis unlike wild-type mice
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• fewer gonadotrophs stain positive for beta-follicle stimulating hormone and beta-luteinizing hormone compared to in wild-type mice
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• in the anterior lobe due to hyperplasia and hypertrophy with prominent vascular spaces
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• 4- to 10-fold
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• mice exhibit peliosis unlike wild-type mice
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• in aged female mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants do not show lower levels of locomotor stimulation in response to a Grm5 antagonist, MPEP, whereas compared to wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit abnormal motor function with reduced horizontal distance, initiation of movement, time in motion, and number of rearing events compared with C57BL/6 mice
• unlike in wild-type mice, locomotor parameters are unaffected by treatment with haloperidol
• reserpine and AMPT-treated mice are slightly more active than C57BL/6 mice
• locomotor parameters are unaffected by treatment with SKF38393 and quinpirole unlike in wild-type mice
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• mice exhibit reduced initiation of movement compared with 129S/SvEv or C57BL/6 mice
|
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• compared with C57BL/6 mice but not 129S/SvEv mice
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• unlike in wild-type mice, locomotor parameters are unaffected by treatment with haloperidol
• reserpine and AMPT-treated mice are slightly more active than similarly treated C57BL/6 mice
• locomotor parameters are unaffected by treatment with SKF38393 and quinpirole unlike similarly treated wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit decreased horizontal distance compared with 129S/SvEv mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit a normal saccharin and quinine preference and locomotor depressant response to SCH-23390 treatment
|
|
• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice
|
|
• mice exhibit decreased horizontal distance and rearing compared with C57BL/6 mice
|
|
• ethanol-treated mice exhibit reduced ataxic response compared with similarly treated wild-type mice
|
|
• mice exhibit increased blood pressure compared with wild-type mice
• however, acute adrenalectomy results in normal blood pressure compared with similarly treated wild-type mice
|
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• compared with wild-type mice or homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit abnormal motor function with reduced horizontal distance, initiation of movement, time in motion, and number of rearing events compared with C57BL/6 mice
• mice treated with SKF38393 and quinpirole exhibit increased horizontal distance compared with similarly treated wild-type mice
|
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• mice treated with SKF38393 and quinpirole exhibit increased horizontal distance compared with similarly treated wild-type mice
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• astrocytes exhibit normalized RNA expression of pro-inflammatory mediators compared to in Drd2tm1Low homozygotes
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• amphetamine-treated mice exhibit a normal increase in locomotor activity
• locomotor activity is normal compared with wild-type mice
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• mice exhibit reduced activity compared with Cm heterozygotes
• however, locomotor activity is normal compared with wild-type mice
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| N |
• extracellular dopamine levels are normal compared with wild-type mice
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• extracellular dopamine levels are reduced compared to in Cm heterozygotes
• however, extracellular dopamine levels are normal compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mutants do not show lower levels of locomotor stimulation in response to a Grm5 antagonist, MPEP, whereas compared to wild-type controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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