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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Msr1tm1Csk
targeted mutation 1, Chugai Pharmaceutical Co, Ltd
MGI:1857874
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Msr1tm1Csk/Msr1tm1Csk involves: 129S7/SvEvBrd * C57BL/6J MGI:3053052
hm2
Msr1tm1Csk/Msr1tm1Csk involves: 129X1/SvJ * ICR MGI:2174971
cx3
Marcotm1Ktry/Marcotm1Ktry
Msr1tm1Csk/Msr1tm1Csk
B6.129-Marcotm1Ktry Msr1tm1Csk MGI:3714850
cx4
Apoetm1Unc/Apoetm1Unc
Msr1tm1Csk/Msr1tm1Csk
either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR) MGI:2177115
cx5
Msr1tm1Csk/Msr1tm1Csk
Scarf1tm1Ishi/Scarf1tm1Ishi
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J MGI:3053051
cx6
Msr1tm1Csk/Msr1tm1Csk
Tg(APPV717F)109Ili/?
involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR MGI:2177120


Genotype
MGI:3053052
hm1
Allelic
Composition
Msr1tm1Csk/Msr1tm1Csk
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation (2 available); any Msr1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

hematopoietic system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis




Genotype
MGI:2174971
hm2
Allelic
Composition
Msr1tm1Csk/Msr1tm1Csk
Genetic
Background
involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation (2 available); any Msr1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decreased survival after infection with Listeria monocytogenes
• decreased survival after infection with herpes simplex virus, HSV-1

immune system
• mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice
• decreased survival after infection with Listeria monocytogenes
• decreased survival after infection with herpes simplex virus, HSV-1




Genotype
MGI:3714850
cx3
Allelic
Composition
Marcotm1Ktry/Marcotm1Ktry
Msr1tm1Csk/Msr1tm1Csk
Genetic
Background
B6.129-Marcotm1Ktry Msr1tm1Csk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marcotm1Ktry mutation (1 available); any Marco mutation (11 available)
Msr1tm1Csk mutation (2 available); any Msr1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
• anti-polysaccharide IgM levels are increased
• macrophage adhesion or spreading is absent
• following immunization and infection with pneumoccocal bacterial serotype, mice have a decreased anti-polysaccharide IgM response
• following immunization and infection with pneumoccocal bacterial serotype, IgG3 response is virtually non-existent

hematopoietic system
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
• anti-polysaccharide IgM levels are increased
• macrophage adhesion or spreading is absent




Genotype
MGI:2177115
cx4
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Msr1tm1Csk/Msr1tm1Csk
Genetic
Background
either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (22 available); any Apoe mutation (68 available)
Msr1tm1Csk mutation (2 available); any Msr1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• atherosclerotic plaques, but smaller than those seen in Apoetm1Unc mutant mice

homeostasis/metabolism
• increased plasma cholesterol concentrations
• plasma cholesterol concentrations greater than Apoetm1Unc mutant mice




Genotype
MGI:3053051
cx5
Allelic
Composition
Msr1tm1Csk/Msr1tm1Csk
Scarf1tm1Ishi/Scarf1tm1Ishi
Genetic
Background
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation (2 available); any Msr1 mutation (4 available)
Scarf1tm1Ishi mutation (0 available); any Scarf1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes

hematopoietic system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes




Genotype
MGI:2177120
cx6
Allelic
Composition
Msr1tm1Csk/Msr1tm1Csk
Tg(APPV717F)109Ili/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation (2 available); any Msr1 mutation (4 available)
Tg(APPV717F)109Ili mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili
• loss of synaptophysin-immunoreactive presynaptic terminals in the hippocampal outer molecular layer (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili )
• reduced density of MAP-2 immuoreactive neuronal dendrites in the outer molecular layer of the hippocampus (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili)

homeostasis/metabolism
• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:58338





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory