Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation
(4 available);
any
Msr1 mutation
(10 available)
|
|
|
immune system
|
|
• in peritoneal macrophages stimulated with poly(I:C)
• however, TLR3 signaling is rescued by treatment with DOTAP
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation
(4 available);
any
Msr1 mutation
(10 available)
|
|
|
immune system
|
|
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
|
hematopoietic system
|
|
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation
(4 available);
any
Msr1 mutation
(10 available)
|
|
|
mortality/aging
|
|
• decreased survival after infection with Listeria monocytogenes
|
|
|
• decreased survival after infection with herpes simplex virus, HSV-1
|
immune system
|
|
• mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice
|
|
|
• decreased survival after infection with Listeria monocytogenes
|
|
|
• decreased survival after infection with herpes simplex virus, HSV-1
|
immune system
|
|
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
|
|
|
• anti-polysaccharide IgM levels are increased
|
|
|
• macrophage adhesion or spreading is absent
|
|
|
• following immunization and infection with pneumoccocal bacterial serotype, mice have a decreased anti-polysaccharide IgM response
• following immunization and infection with pneumoccocal bacterial serotype, IgG3 response is virtually non-existent
|
hematopoietic system
|
|
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
|
|
|
• anti-polysaccharide IgM levels are increased
|
|
|
• macrophage adhesion or spreading is absent
|
cardiovascular system
|
|
• atherosclerotic plaques, but smaller than those seen in Apoetm1Unc mutant mice
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation
(4 available);
any
Msr1 mutation
(10 available)
Scarf1tm1Ishi mutation
(0 available);
any
Scarf1 mutation
(38 available)
|
|
|
immune system
|
|
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes
|
hematopoietic system
|
|
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msr1tm1Csk mutation
(4 available);
any
Msr1 mutation
(10 available)
Tg(APPV717F)109Ili mutation
(0 available)
|
|
|
nervous system
|
|
• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili
|
|
|
• loss of synaptophysin-immunoreactive presynaptic terminals in the hippocampal outer molecular layer (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili )
• reduced density of MAP-2 immuoreactive neuronal dendrites in the outer molecular layer of the hippocampus (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili)
|
homeostasis/metabolism
Analysis Tools
