• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

• decreased survival after infection with Listeria monocytogenes

• decreased survival after infection with herpes simplex virus, HSV-1

• mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice

• decreased survival after infection with Listeria monocytogenes

• decreased survival after infection with herpes simplex virus, HSV-1

• atherosclerotic plaques, but smaller than those seen in Apoe^tm1Unc mutant mice

• increased plasma cholesterol concentrations

• plasma cholesterol concentrations greater than Apoe^tm1Unc mutant mice

• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

• this reduction is slightly greater than that of Msr1^tm1Kod homozygotes

• microarchitecture of the spleen marginal zone is altered

• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marco^tm1Ktry homozygotes

• anti-polysaccharide IgM levels are increased

• macrophage adhesion or spreading is absent

• following immunization and infection with pneumoccocal bacterial serotype, mice have a decreased anti-polysaccharide IgM response

• following immunization and infection with pneumoccocal bacterial serotype, IgG3 response is virtually non-existent

• microarchitecture of the spleen marginal zone is altered

• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marco^tm1Ktry homozygotes

• loss of synaptophysin-immunoreactive presynaptic terminals in the hippocampal outer molecular layer (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili )

• reduced density of MAP-2 immuoreactive neuronal dendrites in the outer molecular layer of the hippocampus (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili)

• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili

• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili