Mouse Genome Informatics
hm1
    Msr1tm1Csk/Msr1tm1Csk
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis

hematopoietic system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis


Mouse Genome Informatics
hm2
    Msr1tm1Csk/Msr1tm1Csk
involves: 129X1/SvJ * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• decreased survival after infection with Listeria monocytogenes
• decreased survival after infection with herpes simplex virus, HSV-1

immune system
• mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice
• decreased survival after infection with Listeria monocytogenes
• decreased survival after infection with herpes simplex virus, HSV-1


Mouse Genome Informatics
cx3
    Marcotm1Ktry/Marcotm1Ktry
Msr1tm1Csk/Msr1tm1Csk

B6.129-Marcotm1Ktry Msr1tm1Csk
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
• anti-polysaccharide IgM levels are increased
• macrophage adhesion or spreading is absent
• following immunization and infection with pneumoccocal bacterial serotype, mice have a decreased anti-polysaccharide IgM response
• following immunization and infection with pneumoccocal bacterial serotype, IgG3 response is virtually non-existent

hematopoietic system
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
• anti-polysaccharide IgM levels are increased
• macrophage adhesion or spreading is absent


Mouse Genome Informatics
cx4
    Apoetm1Unc/Apoetm1Unc
Msr1tm1Csk/Msr1tm1Csk

either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• atherosclerotic plaques, but smaller than those seen in Apoetm1Unc mutant mice

homeostasis/metabolism
• increased plasma cholesterol concentrations
• plasma cholesterol concentrations greater than Apoetm1Unc mutant mice


Mouse Genome Informatics
cx5
    Msr1tm1Csk/Msr1tm1Csk
Scarf1tm1Ishi/Scarf1tm1Ishi

involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes

hematopoietic system
• macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis
• this reduction is slightly greater than that of Msr1tm1Kod homozygotes


Mouse Genome Informatics
cx6
    Msr1tm1Csk/Msr1tm1Csk
Tg(APPV717F)109Ili/?

involves: 129X1/SvJ * C57BL/6 * DBA/2 * ICR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili
• loss of synaptophysin-immunoreactive presynaptic terminals in the hippocampal outer molecular layer (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili )
• reduced density of MAP-2 immuoreactive neuronal dendrites in the outer molecular layer of the hippocampus (loss was similar to that seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili)

homeostasis/metabolism
• number and distribution of plaques was similar to those seen in wild-type (Msr1+) mice heterozygous for Tg(APP)109Ili

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:58338