Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1tm3Mrc mutation
(0 available);
any
Hoxb1 mutation
(24 available)
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craniofacial
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• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes
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nervous system
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• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm3.1Mrc mutation
(0 available);
any
Hoxa1 mutation
(14 available)
Hoxb1tm3Mrc mutation
(0 available);
any
Hoxb1 mutation
(24 available)
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nervous system
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• apoptosis in the hindbrain is increased and extends more posteriorly than in Hoxa1 null mice
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• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
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• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5
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vision/eye
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• mice lack the orbicularis occuli muscle
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embryo
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• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5
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• the second branchial pouch is absent
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• the shape of the third pharyngeal pouch is distorted
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craniofacial
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• the incus is reduced in size
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• the stapes derived from the second branchial arch is absent
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• mice lack the orbicularis occuli muscle
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• mice lack the levator labii maxillaris, orbicularis occuli and zygomatic muscles
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• mice lack the levator labii maxillaris
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• mice lack the zygomatic muscles
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endocrine/exocrine glands
hearing/vestibular/ear
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• the incus is reduced in size
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• the stapes derived from the second branchial arch is absent
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respiratory system
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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• at birth, mice exhibit lung hypoplasia that ranges from 5 small lobes to the presence of only two lobes
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muscle
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• mice lack the orbicularis occuli muscle
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• mice lack the levator labii maxillaris, orbicularis occuli and zygomatic muscles
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• mice lack the levator labii maxillaris
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• mice lack the zygomatic muscles
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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immune system
skeleton
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• the incus is reduced in size
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• the stapes derived from the second branchial arch is absent
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hematopoietic system
cellular
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• apoptosis in the hindbrain is increased and extends more posteriorly than in Hoxa1 null mice
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• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
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growth/size/body
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• mice lack the orbicularis occuli muscle
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• mice lack the levator labii maxillaris, orbicularis occuli and zygomatic muscles
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• mice lack the levator labii maxillaris
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• mice lack the zygomatic muscles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm3.1Mrc mutation
(0 available);
any
Hoxa1 mutation
(14 available)
Hoxb1tm3Mrc mutation
(0 available);
any
Hoxb1 mutation
(24 available)
|
|
|
nervous system
|
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• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
|
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• hindbrain organization into even- and odd-numbered rhombomeres is lacking
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embryo
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• hindbrain organization into even- and odd-numbered rhombomeres is lacking
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• some mice exhibit a distortion of the second and third pouch towards the first
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craniofacial
endocrine/exocrine glands
hematopoietic system
immune system
cellular
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• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
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Analysis Tools