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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hoxb1tm3Mrc
targeted mutation 3, Mario R Capecchi
MGI:1857859
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hoxb1tm3Mrc/Hoxb1tm3Mrc Not Specified MGI:3773290
cx2
Hoxa1tm3.1Mrc/Hoxa1tm3.1Mrc
Hoxb1tm3Mrc/Hoxb1tm3Mrc
involves: 129S1/Sv * 129X1/SvJ MGI:3773291
cx3
Hoxa1tm3.1Mrc/Hoxa1tm3.1Mrc
Hoxb1tm3Mrc/Hoxb1+
involves: 129S1/Sv * 129X1/SvJ MGI:3773292


Genotype
MGI:3773290
hm1
Allelic
Composition
Hoxb1tm3Mrc/Hoxb1tm3Mrc
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1tm3Mrc mutation (0 available); any Hoxb1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes

nervous system
• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes




Genotype
MGI:3773291
cx2
Allelic
Composition
Hoxa1tm3.1Mrc/Hoxa1tm3.1Mrc
Hoxb1tm3Mrc/Hoxb1tm3Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm3.1Mrc mutation (0 available); any Hoxa1 mutation (7 available)
Hoxb1tm3Mrc mutation (0 available); any Hoxb1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• apoptosis in the hindbrain is increased and extends more posteriorly than in Hoxa1 null mice
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5

embryo
• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5
• the second branchial pouch is absent
• the shape of the third pharyngeal pouch is distorted

craniofacial
• the incus is reduced in size
• the stapes derived from the second branchial arch is absent
• mice lack the levator labii maxillaries, orbicularis occuli and zygomatic muscles
• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle

endocrine/exocrine glands

hearing/vestibular/ear
• the incus is reduced in size
• the stapes derived from the second branchial arch is absent

respiratory system
• at birth, mice exhibit lung hypoplasia that ranges from 5 small lobes to the presence of only two lobes

muscle
• mice lack the levator labii maxillaries, orbicularis occuli and zygomatic muscles
• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle

immune system

skeleton
• the incus is reduced in size
• the stapes derived from the second branchial arch is absent

hematopoietic system

cellular
• apoptosis in the hindbrain is increased and extends more posteriorly than in Hoxa1 null mice
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice

growth/size/body
• mice lack the levator labii maxillaries, orbicularis occuli and zygomatic muscles
• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle




Genotype
MGI:3773292
cx3
Allelic
Composition
Hoxa1tm3.1Mrc/Hoxa1tm3.1Mrc
Hoxb1tm3Mrc/Hoxb1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1tm3.1Mrc mutation (0 available); any Hoxa1 mutation (7 available)
Hoxb1tm3Mrc mutation (0 available); any Hoxb1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
• hindbrain organization into even- and odd-numbered rhombomeres is lacking

embryo
• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• some mice exhibit a distortion of the second and third pouch towards the first

craniofacial

endocrine/exocrine glands

hematopoietic system

immune system

cellular
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice





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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory