Mouse Genome Informatics
hm1
    Hoxb1tm3Mrc/Hoxb1tm3Mrc
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
craniofacial
• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes

nervous system
• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes


Mouse Genome Informatics
cx2
    Hoxa1tm3.1Mrc/Hoxa1tm3.1Mrc
Hoxb1tm3Mrc/Hoxb1tm3Mrc

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5
• apoptosis in the hindbrain is increased and extends more posteriorly than in Hoxa1 null mice

embryogenesis
• the second branchial pouch is absent and the shape of the third is distorted
• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5

craniofacial
• the incus is reduced in size
• the stapes derived from the second branchial arch is absent
• mice lack the levator labii maxillaries, orbicularis occuli and zygomatic muscles
• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle

endocrine/exocrine glands

hearing/vestibular/ear
• the incus is reduced in size
• the stapes derived from the second branchial arch is absent

respiratory system
• at birth, mice exhibit lung hypoplasia that ranges from 5 small lobes to the presence of only two lobes

muscle
• mice lack the levator labii maxillaries, orbicularis occuli and zygomatic muscles
• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle

immune system

skeleton
• the incus is reduced in size
• the stapes derived from the second branchial arch is absent

hematopoietic system

cellular
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice


Mouse Genome Informatics
cx3
    Hoxa1tm3.1Mrc/Hoxa1tm3.1Mrc
Hoxb1tm3Mrc/Hoxb1+

involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
• hindbrain organization into even- and odd-numbered rhombomeres is lacking

embryogenesis
• some mice exhibit a distortion of the second and third pouch towards the first
• hindbrain organization into even- and odd-numbered rhombomeres is lacking

craniofacial

endocrine/exocrine glands

hematopoietic system

immune system

cellular
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice